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All Journal International Journal of Integrated Health Sciences Majalah Kedokteran Bandung Althea Medical Journal Jurnal Sistem Kesehatan Indonesian Journal of Kidney and Hypertension
Afiatin Afiatin
Division Of Nephrology And Hypertension, Department Of Internal Medicine, Faculty Of Medicine Universitas Padjadjaran/ Dr. Hasan Sadikin General Hospital Bandung
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Journal : althea medical journal

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The Effect of Breadfruit Leaves Infusion on Acute Renal Failure Rat model Abstract Hardani, Muhamad Risdan; Sastramihardja, Herri S.; Afiatin, Afiatin
Althea Medical Journal Vol 2, No 4 (2015)
Publisher : Althea Medical Journal

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Abstract

Background : Empirically, breadfruit (Artocarpus altilis) leaf has been used as traditional medicine for several diseases, such as acute renal failure. This research is aimed at finding the effects of breadfruit leaf infusion on blood creatinine levels in rats to model acute renal failure.Methods : This research is an experimental study, using 30 male wistar rats, weighing 150–250 g, divided into 5 groups. The first group is a negative control and the second group is a positive control. Groups 2–5 were induced with Gentamicine and peroxicam for 7 days, and then groups 3–5 given infusion of breadfruit leaf in different doses for 7 days, and then blood creatinine levels were tested at the 15th day. This data was analyzed using a multiple comparison Dunnett T3 test because this data is not homogenous. This research was done in pharmacology laboratorium universitas padjadjaran from Oktober–November 2012.Result : Bases on average creatinine levels of 0.62, 0.87, 0.98, and 0.87 mg/dL observed for the diffetent groups, it was statistically show that significantly different creatinine levels, differing by 0.038 (p < 0.05) were observed for the control group and the group which was given an infusion of breadfruit leaf.Conclusion : It can be concluded that infusions of breadfruit leaf do have an effects on blood creatinine levels in acute renal failure.Key words : acute renal failure, breadfruit leaf, creatinine  DOI: 10.15850/amj.v2n4.527
Polypharmacy Treatment of Hypertensionin Public Health Centers A/P Nayagam, Vasanthi; Afiatin, Afiatin; Sastramihardja, Herri S.
Althea Medical Journal Vol 3, No 4 (2016)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (207.515 KB)

Abstract

Background: Hypertension is one of the most prominent global diseases. Despite the availability of effective therapies, hypertension remains poorly controlled in Indonesia. In many cases, patient’s noncompliance may be attributable to the low patients’ knowledge, attitude, and life-style practices such as polypharmacy. Polypharmacy is defined as the administration of many drugs at in one prescription. Polypharmacy increases expenses, possible adverse reaction to a single agent, incidence of drug interactions, and decreases patient’s compliance This study aimed to identify the practice of polypharmacy in hypertension treatment in primary health centers.Methods: A cross-sectional descriptive observational study was carried out on 60 patients from two primary health centers in Jatinangor, West Java, Indonesia in October 2013. Sociodemographic profile, degree of hypertension, types of antihypertensive drugs, concomitant drugs given together with antihypertensive drugs, and treatment compliance data were collected and presented in tables and figures.Results: The incidence of hypertension was more common among male patients compared to female patients. Thirty-three patients (55%) have low compliance to their medication. Twenty-nine patients (48%) received single drug and 31 patients (52%) received more than one drugs.Conclusions: The percentage of polypharmacy practice in treating hypertension in primary health centers is 52%. The most frequently prescribed anti-hypertensive are angiotensin-converting enzyme (ACE) inhibitors and calcium-channel blockers (CCB). Most of hypertensive patients have low compliance to therapy. [AMJ.2016;3(4):633–9] DOI: 10.15850/amj.v3n4.951
The Effect of Breadfruit Leaves Infusion on Acute Renal Failure Rat model Abstract Muhamad Risdan Hardani; Herri S. Sastramihardja; Afiatin Afiatin
Althea Medical Journal Vol 2, No 4 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (560.071 KB)

Abstract

Background : Empirically, breadfruit (Artocarpus altilis) leaf has been used as traditional medicine for several diseases, such as acute renal failure. This research is aimed at finding the effects of breadfruit leaf infusion on blood creatinine levels in rats to model acute renal failure.Methods : This research is an experimental study, using 30 male wistar rats, weighing 150–250 g, divided into 5 groups. The first group is a negative control and the second group is a positive control. Groups 2–5 were induced with Gentamicine and peroxicam for 7 days, and then groups 3–5 given infusion of breadfruit leaf in different doses for 7 days, and then blood creatinine levels were tested at the 15th day. This data was analyzed using a multiple comparison Dunnett T3 test because this data is not homogenous. This research was done in pharmacology laboratorium universitas padjadjaran from Oktober–November 2012.Result : Bases on average creatinine levels of 0.62, 0.87, 0.98, and 0.87 mg/dL observed for the diffetent groups, it was statistically show that significantly different creatinine levels, differing by 0.038 (p < 0.05) were observed for the control group and the group which was given an infusion of breadfruit leaf.Conclusion : It can be concluded that infusions of breadfruit leaf do have an effects on blood creatinine levels in acute renal failure.Key words : acute renal failure, breadfruit leaf, creatinine  DOI: 10.15850/amj.v2n4.527
Polypharmacy Treatment of Hypertensionin Public Health Centers Vasanthi A/P Nayagam; Afiatin Afiatin; Herri S. Sastramihardja
Althea Medical Journal Vol 3, No 4 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (207.515 KB)

Abstract

Background: Hypertension is one of the most prominent global diseases. Despite the availability of effective therapies, hypertension remains poorly controlled in Indonesia. In many cases, patient’s noncompliance may be attributable to the low patients’ knowledge, attitude, and life-style practices such as polypharmacy. Polypharmacy is defined as the administration of many drugs at in one prescription. Polypharmacy increases expenses, possible adverse reaction to a single agent, incidence of drug interactions, and decreases patient’s compliance This study aimed to identify the practice of polypharmacy in hypertension treatment in primary health centers.Methods: A cross-sectional descriptive observational study was carried out on 60 patients from two primary health centers in Jatinangor, West Java, Indonesia in October 2013. Sociodemographic profile, degree of hypertension, types of antihypertensive drugs, concomitant drugs given together with antihypertensive drugs, and treatment compliance data were collected and presented in tables and figures.Results: The incidence of hypertension was more common among male patients compared to female patients. Thirty-three patients (55%) have low compliance to their medication. Twenty-nine patients (48%) received single drug and 31 patients (52%) received more than one drugs.Conclusions: The percentage of polypharmacy practice in treating hypertension in primary health centers is 52%. The most frequently prescribed anti-hypertensive are angiotensin-converting enzyme (ACE) inhibitors and calcium-channel blockers (CCB). Most of hypertensive patients have low compliance to therapy. [AMJ.2016;3(4):633–9] DOI: 10.15850/amj.v3n4.951
Co-Authors A/P Nayagam, Vasanthi Alif Bagus Rakhimullah Andhika, Rizky Andika Wiratama Astried Indrasari Budiman, Muhammad Fitriandi Dwi Agustian Erma Arnika Dewi Evan Susandi Hadyana Sukandar Hadyana Sukandar Herri S. Sastramihardja Kurnia Wahyudi Mariya Ulfah MARIYA ULFAH Muhamad Risdan Hardani Muhamad Risdan Hardani, Muhamad Risdan Pandu Riono Prayudi Santoso Ria Bandiara Rubin Surachno Gondodiputro Rully Marsis Amirullah Roesli Stefanie Yuliana Usman Sukesi, Lilik Tania Tania Vasanthi A/P Nayagam Vycke Yunivita