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All Journal JURNAL FARMASIMED (JFM) Pharmaceutical Science Journal International Journal Of Public Health
Febrianika Ayu Kusumaningtyas
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EFEKTIVITAS EKSTRAK DAUN BINAHONG (Anredera cordifolia (Ten.) Steenis) SEBAGAI ANALGETIK PADA TIKUS PUTIH Meilani Jayanti; Febrianika Ayu Kusumaningtyas; Fatrini Djaber
PHRASE (Pharmaceutical Science) Journal Vol 1, No 1 (2021)
Publisher : Sekolah Tinggi Ilmu Kesehatan Widya Dharma Husada Tangerang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52031/phrase.v1i1.167

Abstract

Ekstrak daun binahong memiliki kandungan senyawa metabolit sekunder yang menjadikan tanaman ini dapat berkhasiat sebagai obat. Penelitian ini bertujuan untuk mengetahui efektivitas ekstrak daun binahong sebagai analgetik pada tikus putih dengan menggunakan metode geliat. Penelitian ini menggunakan hewan uji tikus sebanyak 15 ekor. Tikus tersebut dibagi menjadi 5 kelompok uji, dimana masing-masing kelompok uji terdiri dari 3 ekor tikus. Kelompok uji terdiri dari kontrol negatif, kontrol positif, dosis ekstrak 250 mg/kg, 500 mg/kg dan 1000 mg/kg BB tikus. Pengumpulan data dilakukan dengan mengamati frekuensi geliat tikus, sehingga diperoleh rata-rata jumlah geliat dari setiap kelompok uji, % proteksi dan % efektivitas. Hasil analisis statistik menunjukkan bahwa terdapat perbedaan rata-rata jumlah geliat dengan nilai p=0.000 (p<0.05). Penelitian ini menyimpulkan bahwa ekstrak daun binahong pada dosis 500 mg/kg BB dan 1000 mg/kg BB sudah efektif mengurangi nyeri akibat rangsangan yang diinduksi asam asetat, dengan persentase efektivitas analgetik masing-masing dosis ekstra sebesar 37% dan 63.7%.
Activity Test of N-Hexane Fraction of Takokak Fruit ( Solanum torvum Swartz ) Using Glucose Tolerance Test Method Per Oral (OGTT) in Test Animals White Rats (Rattus norvegicus) Ahlan Sangkal; Rahmat Ismail; Febrianika Ayu Kusumaningtyas
International Journal of Public Health Vol. 1 No. 4 (2024): December : International Journal of Public Health
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62951/ijph.v1i4.265

Abstract

Takokak fruit contains bioactive compounds that can be used as antidiabetics. This study aims to identify bioactive compounds of ethanol extract of takokak fruit and antidiabetic test of n-Hexane fraction. The method used to obtain the extract is maceration using ethanol . Antidiabetic testing is carried out through in vivo testing with the Oral Glucose Tolerance Test (OGTT) method on white rats. Secondary metabolites are compounds contained in taakokak fruit that are identified as flavonoids, saponins, tannins, steroids and terpenoids . The results of the antidiabetic test showed that the n-Hexane fraction with glibencamide as a comparator has the ability as an antidiabetic in terms of the amount of difference in blood glucose levels in the test animal group from T 30 to T 120 . The average decrease in blood glucose levels in the negative control group (Na-CMC) was 108.67 mg/dL, the positive control group ( glibencamide ) 174.67 mg/dL, the 5% concentration fraction group 35.33 mg/dL, the 10% concentration fraction group 30.67 mg/dL, the 20% concentration fraction group 47.67 mg/dL.
Evaluation of the Physical Stability of Body Butter Containing Cocoa Peel Extract (Theobroma cacao L.) Hanapi, Muzdalifah Rizqa R; Febrianika Ayu Kusumaningtyas; Ria Rezki Botutihe
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/7b6v6k12

Abstract

Skin is the outermost part of the human body that interacts directly with the environment, which is one of the risk factors that cause dry skin. Brown skin (Theobroma cacao L.) contains one of the compounds, namely polyphenols which are grouped as a type of flavonoid that can protect the skin from compounds that cause dry skin, sides, dullness, and wrinkles. This study aims to formulate body butter with variations in the concentration of 1% (F1), 3% (F2), 5% (F3) chocolate skin extract which is then tested for physical properties including organoleptical, pH, homogeneity, spreadability, adhesion, and stability using centrifugation. The results showed that cocoa bark extract (Theobroma cacao L.) body butter preparation was not stable in storage for approximately 1 year but remained stable in storage for less than 6 months.
Co-Authors Ahlan Sangkal Fatrini Djaber Hanapi, Muzdalifah Rizqa R Meilani Jayanti Rahmat Ismail Ria Rezki Botutihe