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Meilani Jayanti
Universitas Sam Ratulangi
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Hypoglicemia Risk Factors on Hospitalized Type 2 Diabetes Mellitus Patients Jayanti, Meilani; Lestari, Keri; Abdulah, Rizky
Pharmacology and Clinical Pharmacy Research Vol 3, No 2 (2018)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (434.595 KB)

Abstract

Hypoglycemia is one of the most important complications of diabetes treatment and it becomes an obstacle in hypoglycemia medication. Besides, hypoglycemia can cause nerve damage and impaired cognitive function so that it influences the patients mortality, morbidity, and quality of life. Recognition of hypoglycemia risk factors, blood glucose monitoring, selection of appropriate regimens and educational programs for healthcare professionals and patients with diabetes are the major issues to maintain good glycemic control, minimize the risk of hypoglycemia, and prevent long-term complications. This research employs retrospective method and the design of the research is case control.  The sample of this research is 72 patients with type 2 diabetes which is divided into two groups.  The first group is case and It consists of 23 patients (31,9%) getting hypoglycemia. Then, the second group is control and it consists of 49 patients (68,1%). In the second group the 49 patients do not get hypoglycemia and they do not receive any hypoglycemia medication in the hospital. The Results of multivariate logistic regression analysis shows that there is a significant different between the variables reduction in food intake (p 0,011) and lower laboratory result of HbA1C (p 0,003) on the incidence of hypoglycemic, where the variable reduction in food intake has the strong relationship with most major hypoglycemic (OR 9,329). On the other hand, other variables such as the use of antidiabetic drugs, diabetes duration, age, comorbidities and polypharmacy showed no significant association with hypoglycemic events. Thus, the hypoglycemic risk factors in patients with type 2 diabetes receiving antidiabetic therapy due to reduction in food intake and lower laboratory results of HbA1C. Patients with reduction in food intake at risk of hypoglycemic events nine times greater than patients with normal food intake. Keywords: type 2 diabetes mellitus, hypoglycemia, food intake, HbA1C
PROFIL PENGETAHUAN MASYARAKAT TENTANG PENGOBATAN MANDIRI (SWAMEDIKASI) DI DESA BUKAKA KECAMATAN KOTABUNAN KABUPATEN BOLAANG MONGONDOW TIMUR Jayanti, Meilani; Arsyad, Aswin
PHARMACON Vol 9, No 1 (2020): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.9.2020.27417

Abstract

ABSTRACTThe effort that most done by the community to treat disease before deciding to seek help from health services or health worker is called self medication. The aim of this research is to describe the profile of community knowledge about self medication in Bukaka Village, Kotabunan sub-district, Bolaang Mongndow Timur district. This research is an observational descriptive research which uses analytic survey method. Data collection was carried out from 165 respondents selected based on inclusion and exclusion criteria. Based on this research, it can be concluded that the profile of community knowledge about self-medication (self-medication) in Bukaka Village is still inadequate, where the percentage of community knowledge level of Bukaka Village is 36% which shows how the community's knowledge is categorized as lacking. Keywords: Knowledge, Community, Self Medication  ABSTRAKUpaya yang paling banyak dilakukan oleh masyarakat untuk mengatasi keluhan, gejala penyakit, sebelum memutuskan mencari pertolongan kepada tenaga kesehatan atau sarana pelayanan kesehatan, yaitu dengan melakukan pengobatan mandiri (swamedikasi). Penelitian ini bertujuan untuk mengetahui bagaimana profil pengetahuan masyarakat Desa Bukaka Kecamatan Kotabunan Kabupaten Bolaang Mongndow Timur (boltim) tentang pengobatan mandiri (swamedikasi). Penelitian ini merupakan penelitian observasional dengan jenis penelitian deskriptif yang menggunakan metode survei analitik. Pengambilan data dilakukan terhadap 165 orang responden yang dipilih berdasarkan kriteria inklusi dan eksklusi. Berdasarkan penelitian yang telah dilakukan, dapat disimpulkan bahwa profil pengetahuan masyarakat tentang pengobatan mandiri (swamedikasi) di Desa Bukaka masih kurang dan belum memadai, dimana persentase tingkat pengetahuan masyarakat Desa Bukaka sebesar 36% yang menunjukan bahwa tingkat pengetahuan masyarakat termasuk kategori kurang. Kata Kunci : Pengetahuan, Masyarakat, Swamedikasi 
Isolasi, Identifikasi Senyawa Alkaloid Dan Uji Efektivitas Penghambatan Dari Ekstrak Daun Sirih (Piper betle L.) Terhadap Bakteri Staphylococcus epidermidis Kapondo, Gwendolyn L.; Fatimawali, .; Jayanti, Meilani
e-Biomedik Vol 8, No 2 (2020): eBiomedik
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ebm.v8i2.28999

Abstract

Abstract: Betel leaf (Piper betle L) contains alkaloid compounds and has antibacterial and antiseptic functions. The purpose of this research was to isolated alkaloid compounds also to tested the effectiveness of inhibition of the betel leaf extract against the Staphylococcus epidermidis bacterial growth. Simplicia betel leaf was extracted used 96% of ethanol solvent. Antibacterial activity tested of betel leaf extract with a concentration variation of 25%, 20%, 15%, 10% and 5% using the liquid dilution method. The results of identification of alkaloid isolates used UV-Vis Spectrophotometry method can be known alkaloid compounds contained in betel leaves include alkaloids with indole base framework that was absorption at 262 nm and 274 nm wavelengths. The results of the effectiveness of betel leaf on Bacteria Staphylococcus epidermidis used the liquid dilution method showed that betel leaf extract with Optical density values at concentrations of 25%, 20%, 15% and 10% before and after incubation decreased respectively by -0.347, -0.304, -0.192 and -0.104, while at a concentration of 5% there was increase in Optical density values of 0.162. From the results of the research, it can be concluded that the ethanol extract of betel leaf contains an alkaloid with an indole base framework and was inhibitory activity against Staphylococcus epidermidis bacteria with a MIC at a concentration of 10%.Keywords: betel leaf, Staphylococcus epidermidis, alkaloid compound, liquid dilution.  Abstrak: Daun Sirih (Piper betle L) mengandung senyawa alkaloid dan memiliki fungsi sebagai antibakteri dan antiseptik. Penelitian ini bertujuan untuk mengisolasi senyawa alkaloid dan menguji efektivitas penghambatan dari ekstrak daun sirih hijau terhadap pertumbuhan bakteri Staphylococcus epidermidis. Simplisia daun sirih hijau diekstraksi dengan menggunakan pelarut etanol 96%. Uji aktivitas antibakteri ekstrak daun sirih dengan variasi konsentrasi 25%, 20%, 15%, 10% dan 5% menggunakan metode dilusi cair. Hasil identifikasi terhadap isolat alkaloid menggunakan metode Spektrofotometri UV-Vis dapat diketahui senyawa alkaloid yang terkandung dalam daun sirih termasuk alkaloid dengan kerangka dasar Indol yang mempunyai serapan pada panjang gelombang 262 nm dan 274 nm. Hasil uji efektivitas daun sirih terhadap bakteri Staphylococcus epidermidis dengan metode dilusi cair menunjukan bahwa ekstrak daun sirih dengan nilai densitas optik pada konsentrasi 25%, 20%, 15% dan 10% sebelum dan sesudah inkubasi mengalami penurunan berturut-turut sebesar -0.347, -0.304, -0.192 dan -0.104, sedangkan pada konsentrasi 5% mengalami kenaikan nilai densitas optik sebesar 0.162. Dari hasil penelitian yang diperoleh, dapat disimpulkan bahwa ekstrak etanol daun sirih mengandung alkaloid dengan kerangka dasar indol dan memiliki aktivitas penghambatan terhadap bakteri Staphylococcus epidermidis dengan KHM pada konsentrasi 10%.Kata Kunci: daun sirih, Staphylococcus epidermidis, senyawa alkaloid, dilusi cair.
FORMULASI DAN EVALUASI VARIASI BASIS GEL AIR PERASAN TEMUAWAK (Curcuma xanthorrhiza R.) SEBAGAI ANTISEPTIK TANGAN Fathoni, Kristiani W. S. W.; Edy, Hosea Jaya; Jayanti, Meilani
PHARMACON Vol 10, No 1 (2021): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.10.2021.32751

Abstract

ABSTRACT Temulawak (Curcuma xanthorrhiza R.) is a plant that contains antimicrobial properties of essential oil and curcumin compounds. The purpose of this study was to formulate temulawak juice into gel preparations by varying the HPMC and Carbomer gel bases with each base concentration of 1%, testing the effectiveness of the antiseptic preparations and evaluating the physical preparations of the gel. This study used laboratory experimental methods. temulawak is soaked in aquadest then filtered and centrifuged to obtain temulawak juice and formulated in a gel preparation. Testing the effectiveness as a hand antiseptic using the replica method. The results showed that the temulawak water gel met the physical properties of the gel preparation which included organoleptic test, homogeneity test, pH test, spreadability test, adhesion test, and syneresis test. The percentage of colony decline using the HPMC base was 29.53% and the Carbomer base was 14.74%. This shows that the gel preparation of Temulawak juice cannot reduce the normal flora of the skin so that it does not affect an antiseptic for hands. Key Words : Antiseptic, gel preparations, Curcuma (Curcuma xanthorrhiza R.)  ABSTRAK Temulawak (Curcuma xanthorrhiza R.) merupakan tanaman yang memiliki kandungan senyawa minyak atsiri dan kurkumin yang bersifat antimikroba. Tujuan dari penelitian ini untuk memformulasikan air perasan temulawak menjadi sediaan gel dengan memvariasikan basis gel HPMC dan Karbomer dengan masing-masing konsentrasi basis sebesar 1 %, menguji efektivitas antiseptik sediaan dan mengevaluasi sediaan fisik dari gel tersebut. Penelitian ini menggunakan metode eksperimental laboratorium. Temulawak direndam dengan aquadest kemudian disaring dan disentrifuse untuk mendapatkan air perasan temulawak dan diformulasikan dalam sediaan gel. Pengujian efektivitas sebagai antiseptik tangan menggunakan metode replika. Hasil penelitian menunjukkan bahwa gel air perasan temulawak memenuhi persyaratan sifat fisik sediaan gel yang meliputi uji organoleptik, uji homogenitas, uji pH, uji daya sebar, uji daya lekat dan uji sineresis. Presentase penurunan koloni menggunakan basis HPMC sebesar 29,53 % dan basis Karbomer sebesar 14,74 %. Hal ini menunjukkan bahwa sediaan gel air perasan temulawak tidak dapat menurunkan jumlah flora normal kulit sehingga tidak memiliki efek sebagai antiseptik tangan.  Kata Kunci : Antiseptik, sediaan gel, Temulawak (Curcuma xanthorrhiza R.)
ANALISIS PENGELOLAAN LOGISTIK OBAT DI INSTALASI FARMASI RS ELIM RANTEPAO TORAJA UTARA Liling, Yessi; Citraningtyas, Gayatri; Jayanti, Meilani
PHARMACON Vol 10, No 1 (2021): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.10.2021.32755

Abstract

ABSTRACT Drug logistics management is an application of management principles in logistics activities. The purpose of this study was to analyze the suitability of drug logistics management at the Pharmacy Installation of Elim Rantepao Hospital Toraja Utara against the Regulation of the Minister of Health No. 72 of 2016 on Hospital Pharmaceutical Service Standards. The method used in this research is descreptive qualitative. Data collection in this study was conducted by interview and observation. The results of this study prove drug vacancies often occur due to the distance between drug distributors, and well as inadequate pharmaceutical warehouse facilities. This study concluded that the management of drug logistics at IFRS Elim Rantepao Toraja Utara is not yet in accordance with Regulation of the Minister of Health No. 72 of 2016 on Hospital Pharmaceutical Service Standards. Keywords:  Management, drug logistics, Pharmacy, Hospital   ABSTRAK  Manajemen logistik obat adalah suatu penerapan prinsip-prinsip manajemen adalam kegiatan logistik. Tujuan dari penelitian ini menganalisis kesesuaian manajemen logistik obat di Instalasi Farmasi RS Elim Rantepao Toraja Utara terhadap Peraturan Menteri Kesehatan Nomor 72 Tahun 2016 tentang Standar Pelayanan Kefarmasian Rumah Sakit. Metode yang digunakan dalam penelitian ini adalah kualitatif deskreptif. Pengumpulan data pada penelitian ini dilakukan dengan cara wawancara dan observasi. Hasil penelitian ini membuktikan bahwa sering terjadi kekosongan obat disebabkan jarak distributor obat yang jauh, dan fasilitas gudang yang tidak memadahi. Penelitian ini menyimpulkan bahwa pengelolaan logistik obat di IFRS Elim Rantepao Toraja Utara belum sesuai dalam Peraturan Menteri Kesehatan Nomor 72 tahun 2016 tentang Standar Pelayanan Kefarmasian Rumah Sakit. Kata kunci: Manajemen, logistik obat, Farmasi, Rumah Sakit
UJI AKTIVITAS ANTIBAKTERI EKSTRAK DAN FRAKSI ASCIDIAN (Lissoclinum badium) DARI PERAIRAN PULAU MANTEHAGE Woran, Falinry; Wewengkang, Defny S.; Jayanti, Meilani
PHARMACON Vol 10, No 2 (2021): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.10.2021.34041

Abstract

ABSTRACTLissoclinum badium is a type of ascidian that contains bioactive compounds. This study aims to determine of presence of antibacterial activity from extracts and fractions of Lissoclinum badium collected from Mantehage Island Manado against Escherichia coli and Staphylococcus aureus bacteria. Samples were extracted by maceration method using 95% ethanol solvent and fractionated using solvents of chloroform, n-hexane and methanol. Antibacterial activity was carried out by the disk diffusion agar method. The results showed that the ethanol extracts an methanol fraction had activity to inhibit the growth of Escherichia coli bacteria with strong category. Meanwhile, against the Staphylococcus aureus the ethanol extracts, chloroform and n-hexane fractions had ability to inhibit the growth of bacteria with weak category.. Keywords: Antibacterial activity, Lissoclinum badium, Escherichia coli, Staphylococcus aureus.  ABSTRAKLissoclinum badium merupakan salah satu jenis tunikata yang memiliki kandungan senyawa bioaktif yang dapat digunakan untuk pengobatan berbagai penyakit. Penelitian ini bertujuan untuk mengetahui adanya aktivitas antibakteri dari ekstrak dan fraksi  Lissoclinum badium yang diperoleh dari Pulau Mantehage Manado terhadap Escherichia coli dan Staphylococcus aureus. Sampel diekstraksi dengan metode maserasi menggunakan pelarut etanol 95% dan fraksinasi menggunakan pelarut metanol, kloroform, dan n-heksan. Aktivitas antibakteri dilakukan dengan  metode difusi agar cakram kertas. Hasil penelitian menunjukkan bahwa ekstrak etanol dan fraksi metanol memiliki aktivitas untuk menghambat bakteri Escherichia coli dan Staphylococcus aureus dengan daya hambat kuat. Sedangkan untuk fraksi kloroform dan fraksi n-heksan memiliki aktivitas untuk menghambat bakteri Staphylococcus aureus saja dengan daya hambat sedang. Kata kunci: Aktivitas antibakteri, Lissoclinum badium, Escherichia coli, Staphylococcus aureus.
EVALUASI MANAJEMEN LOGISTIK OBAT DI INSTALASI FARMASI RSUD KABUPATEN KEPULAUAN TALAUD Essing, Jacklien Deswita; Citraningtyas, Gayatri; Jayanti, Meilani
PHARMACON Vol 9, No 4 (2020): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.9.2020.31354

Abstract

ABSTRACT Evaluation of drug logistics management in pharmacy installation of Regional Public Hospital of Talaud Regency is need to be done to prevent drugs vacancies and in order to meet pharmaceutical service standar in a hospital. This research aims to evaluate logistic management of drug in regional public hospital of Talaud whether on accordance with the Regulation of the Minister of Health Number 72 in 2016. This reseach is a non-experimental research that is descriptive with qualitative methods. Data calculation is qualitative data obstain through interview and direct observation. Data analysis by using content analysis method. The result of interview and observation is show that sometimes there be drug vacancies, no drug withdrawal and drug removal as well as inadequate pharmaceutical ware house facilities. The conclusion is the drug logistics management in pharmacautical insatallation of regional public hospital of Talaud regency is not run according to the standard of pharmaceutical services in the hospital according to the Regulation of Minister of Health Number 72 in 2016.Keywords : Management, Drug Logistics, Pharmacy ABSTRAK  Evaluasi manajemen logistik obat di Instalasi Farmasi RSUD Kabupaten Kepulauan Talaud perlu dilakukan untuk mencegah kekosongan obat dan agar dapat memenuhi Standar Pelayanan Kefarmasian di Rumah Sakit. Penelitian ini bertujuan untuk mengevaluasi manajemen logistik obat di Instalasi Farmasi RSUD Kabupaten Kepulauan Talaud apakah sudah sesuai dengan Peraturan Menteri Kesehatan Nomor 72 Tahun 2016. Penelitian ini merupakan jenis penelitian non eksperimental bersifat deskriptif dengan metode kualitatif. Pengumpulan data berupa data kualitatif yang diperoleh melalui wawancara dan observasi langsung.  Data dianalisis menggunakan metode content analysis (analisis isi). Hasil penelitian melalui wawancara dan obervasi langsung menunjukkan sering terjadinya kekosongan obat, belum pernah dilakukannya penarikan dan pemusnahan obat serta fasilitas gudang farmasi yang belum memadai. kesimpulan yaitu manajemen logistik obat di Instalasi Farmasi RSUD Kabupaten Kepulauan Talaud belum berjalan sesuai standar pelayanan kefarmasian di Rumah Sakit dalam Peraturan Menteri Kesehatan Nomor 72 Tahun 2016 yang sudah ditetapkan.Kata kunci : Manajemen, Logistik Obat, Instalasi Farmasi
Uji Efektivitas Penghambatan Dari Ekstrak Daun Sirih (Piper Betle L.) Terhadap Bakteri Streptococcus mutans Owu, Nadya M.; Fatimawali, .; Jayanti, Meilani
Jurnal Biomedik : JBM Vol 12, No 3 (2020): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.12.3.2020.29185

Abstract

Abstract: Betel (Piper Betle L.) is one of the species of climbing plants belonging to the family Piperaceae, betel leaves contain tannin compound that are antimicrobial and can inhibit the growth of several types of bacteria. This study aims to identify tannin compounds from betel leaf extracts obtained from Southeast Minahasa and test the effectiveness of inhibition of Streptococcus mutans. Samples were extracted by maceration using ethanol as a solvent. Fractionation using n-hexane, ethyl acetate and ethanol. Antibacterial activity was tested on extracts with concentrations of 25%, 20%, 15%, 10% and 5% by the dilution method. The tannin test results showed that of the three n-hexane, ethyl acetate and ethanol fractions, only the ethanol fraction had a blackish green discoloration when FeCl3 reagent was added so that it positively contained tannin. The inhibitory test results obtained that the betel leaf ethanol extract with a concentration of 25%, 20% and 15% can inhibit the growth of Streptococcus mutans bacteria. From the results of the study it can be concluded that the ethanol extract of betel leaf contains tannin compounds and effectively inhibits the Streptococcus mutans bacteria with a MIC value at a concentration of 15%.Keywords: Betel leaf, Tannin, Antibacterial, Streptococcus mutans.  Abstrak: Sirih (Piper Betle L) merupakan salah satu jenis tumbuhan terna memanjat yang termasuk famili Piperaceae, daun sirih mengandung senyawa tannin yang bersifat antimikroba dan antijamur yang kuat dan dapat menghambat pertumbuhan beberapa jenis bakteri. Penelitian ini bertujuan untuk mengidentifikasi senyawa tanin dari ekstrak daun sirih yang diperoleh dari Minahasa Tenggara dan menguji efektifitas penghambatannya terhadap Streptococcus mutans. Sampel diekstraksi dengan cara maserasi menggunakan pelarut etanol. Fraksinasi menggunakan pelarut n-Heksan, etil asetat dan etanol. Aktivitas antibakteri diuji terhadap ekstrak dengan konsentrasi 25%, 20%, 15%, 10% dan 5% dengan metode dilusi. Hasil uji tanin diperoleh bahwa dari ketiga fraksi n-Heksan, etil asetat dan etanol, hanya fraksi etanol yang ketika ditambahkan pereaksi FeCl3 terjadi perubahan warna hijau kehitaman sehingga positif mengandung tannin. Hasil uji daya hambat diperoleh bahwa ekstrak etanol daun sirih dengan konsentrasi 25%, 20% dan 15% dapat menghambat pertumbuhan bakteri Streptococcus mutans. Dari hasil penelitian dapat disimpulkan bahwa ekstrak etanol daun sirih mengandung senyawa tannin dan efektif menghambat bakteri Streptococcus mutans dengan nilai KHM pada konsentrasi 15%.Kata kunci: Daun sirih, Tanin, Antibakteri , Streptococcus mutans.
Identifikasi Ketidaksesuaian Pengobatan pada Proses Rekonsiliasi Obat di Instalasi Rawat Inap Rumah Sakit Manuel, Jennike T.; Wiyono, Wenny I.; Jayanti, Meilani
Jurnal Biomedik : JBM Vol 13, No 3 (2021): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.13.3.2021.31769

Abstract

Abstract: Reconciliation is one of the proces that prevents drug-related problems, medication errors, and drug-related adverse events. This study aimed to identify treatment mismatches based on the results of drug reconciliation in 49 patients from the January to March 2020 study period. This research has been descriptive study with prospective data collection in inpatient installation CVBC (Cardiovascular and Brain Center) and Irina F Jantung, Prof. Dr. R. D. Kandou Manado.The results of the study based on patient characteristics showed that the number of male patients was greater than that of women, namely 31 patients and the highest number of patients was in the age group (60 - 69) as many as 23 patients. The results showed that the majority of patients were male as many as 31 patients and the most in the age group (60-69) as many as 23 patients. The characteristics of the number of drugs shown in the drug history data (BPMH), the majority of patients consumed <5 types of drugs, were 25 patients, in the ER Most consumed <5 types of drugs as many as 27 patients and also the majority of patients received ≥5 types of drugs while in the inpatient installation of 27 patients and when they left the hospital the majority of patients were given ≥5 types of drugs, namely 34 patients. The most widely used drugs are cardiovascular system drugs with a percentage of BPMH (95.92%), IGD (100%), in inpatient installations (100%) and out of prescription (100%) and the second is digestive system drugs. The percentage of unintentional discepancies was incomplete prescription (10.2%), omission medication (10.2%), and intentional discrepancies (100%).Keywords: medication discrepancies, medication reconciliation  Abstrak: Rekonsiliasi merupakan salah satu proses yang dilakukan untuk mencegah terjadinya kesalahan obat. Penelitian ini bertujuan mengidentifikasi ketidaksesuaian pengobatan berdasarkan hasil rekonsiliasi obat pada 49 pasien periode Januari–Maret 2020. Desain penelitian deskriptif dengan pengambilan data secara prospektif di instalasi rawat inap CVBC (Cardiovascular and Brain Center) dan Irina F Jantung RSUP Prof. Dr. R. D. Kandou Manado. Hasil penelitian menunjukkan mayoritas pasien adalah laki-laki sebanyak 31 pasien dan terbanyak pada kelompok usia (60-69) sebanyak 23 pasien. Karakteristik jumlah obat ditunjukkan pada data riwayat obat (BPMH) mayoritas pasien mengkonsumsi <5 jenis obat sebanyak 25 pasien, di IGD Sebagian besar mengkonsumsi <5 jenis obat sebanyak 27 pasien dan juga mayoritas pasien menerima  jenis obat saat di Instalasi rawat inap sebesar 27 pasien dan saat keluar rumah sakit mayoritas pasien diberikan  jenis obat yaitu 34 pasien. Obat yang paling banyak digunakan yaitu obat sistem kardiovaskular dengan presentase pada BPMH (95,92%), IGD (100%), di Instalasi rawat inap (100%) dan pada resep keluar (100%) dan yang kedua obat sistem pencernaan. Persentase ketidaksesuaian pengobatan yaitu Incomplete prescription sebesar (10,2%), Omission medication (10,2 %), dan ketidaksesuaian yang disengaja (100%).Kata kunci: rekonsiliasi, ketidaksesuaian pengobatan
UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL SPONS Callyspongia aerizusa DARI PULAU MANTEHAGE KABUPATEN MINAHASA UTARA Soleman, Puput; Yudistira, Adithya; Jayanti, Meilani
PHARMACON Vol 10, No 3 (2021): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.10.2021.35598

Abstract

ABSTRACTSponges are one of the biota components that make up coral reefs that have bioactive potential, which has not been widely utilized. Callyspongia aerizusa is a sponge that has a compound with high activity and has a porous body surface structure. Antioxidants are compounds that can inhibit free radicals in the body, and inhibit oxidation of body cells, thereby preventing or reducing cell damage. This study aims to determine the antioxidant activity of the ethanol extracts of Sponges Callyspongia aerizusa from the waters of Mantehage Island. The Sponge Callyspongia aerizusa was extracted using the maceration method with ethanol as the solvent. Antioxidant activity testing was carried out using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method with a concentration of 0.5 mg / L, 0.6 mg / L, and 0.7 mg / L which were measured using a UV-Vis spectrophotometer at the wavelength 517 nm. The results showed that the ethanol extracts of Sponge Callyspongia aerizusa was proven to have antioxidant activity. The highest antioxidant content was found at the concentration of 0.7 mg / L with an antioxidant activity of 58.40%. Keywords: Antioxidant, Callyspongia aerizusa, DPPH, Mantehage ABSTRAKSpons merupakan salah satu komponen biota penyusun terumbu karang yang mempunyai potensi bioaktif yang belum banyak dimanfaatkan. Callyspongia aerizusa ialah salah satu spons yang memiliki senyawa dengan aktivitas tinggi dan memiliki struktur permukaan tubuh yang berpori – pori. Antioksidan merupakan senyawa yang dapat menghambat radikal bebas dalam tubuh, serta menghambat terjadinya oksidasi pada sel tubuh, sehingga dapat mencegah atau mengurangi terjadinya kerusakan sel. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan dari ekstrak etanol Spons Callyspongia aerizusa dari perairan Pulau Mantehage. Spons Callyspongia aerizusa diekstraksi menggunakan metode maserasi dengan etanol sebagai pelarut. Pengujian aktivitas antioksidan dilakukan dengan metode DPPH (1,1-difenil-2-pikrilhidrazil) dengan konsentrasi 0,5 mg/L, 0,6 mg/L, dan  0,7 mg/L yang diukur menggunakan Spektrofotometer UV-Vis pada panjang gelombang 517 nm. Hasil penelitian menunjukkan bahwa ekstrak etanol Spons Callyspongia aerizusa terbukti memiliki aktivitas antioksidan. Kadar antioksidan tertinggi terdapat pada konsentrasi 0,7 mg/L dengan aktivitas antioksidan sebesar 58,40%. Kata Kunci: Antioksidan, Spons Callyspongia aerizusa, DPPH, Mantehage
Co-Authors Abdullah, Surya Sumantri Adithya Yudistira Andi Buanasari Andy A.N Hiola Angmalisang, Elvin Clara Antasionasti, Irma Arsyad, Aswin ASARI Asep Rahman Asep Rahman, Asep Ayu Wati Ningsih Buanasari, Andi Christian Alexandro Lanes Christian Aseng Citra Fatima Marsidi Debora Gebby Tumundo DEBY AFRIANI MPILA Defny S. Wewengkang, Defny S. Dian Suryanita Sari Eldy Sengkey Elly Suoth Essing, Jacklien Deswita Fadila Al-A’izzah Fathoni, Kristiani W. S. W. Fatimawali . Fatrini Djaber Febrianika Ayu Kusumaningtyas Frenly Wehantouw Gayatri Citraningtyas Gunawan, Lea Nathaniela Agneta Hariyanto, Yuanita A. Hariyanto, Yuanita Amalia Herny E.I. Simbala Hiola, Andy A.N Hosea Jaya Edy I Dewa Ayu M. Melaniawati Ihsan S. Tome Imam Jayanto Irma Antasionasti Jayanto, Imam Julianri Sari Lebang, Julianri Sari Kapondo, Gwendolyn L. Kawatu, Chelsea Keri Lestari Lestari, Utami Sasmita Liling, Yessi Manuel, Jennike T. Maria Efrani Tengor Olvi Datu Owu, Nadya M. Rizky Abdulah Rizya Marchilia Mamahit Sarai Raehilda Febriansi Korban Sengkey, Eldy Shabrina Wahyudi Sharon Colin Tangkere Siampa, Jainer Pasca Soleman, Puput Sri Sudewi, Sri Surya Sumantri Abdullah Tengor, Maria Efrani Ticoalu, Pricilia Kesia Tinungki, Syalomita Esther Tome, Ihsan S. Wenas, Glori Anjelina Preysi Weny I. Wiyono Weny I. Wiyono Weny Indayany Wiyono Weny Indayany Wiyono Weny Indayany Wiyono Weny Wiyono Wiyono, Wenny I. Wiyono, Weny Indayany Woran, Falinry Wori, Preicy Augenia