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All Journal Duta Pharma Journal International Journal of Health, Engineering and Technology Journal of Educational Innovation and Public Health Detector: Jurnal Inovasi Riset Ilmu Kesehatan
Anita Dwi Septiarini
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mechanical Engineering Medicine & Pharmacology Nursing Public Health Veterinary

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Formulasi Dan Uji Mutu Fisik Sediaan Spray Gel Ekstrak Etanol Daun Nipah (Nypah fructicans. Wurmb) Sebagai Terapi Pengobatan Luka Sayat Terhadap Kelinci (New Zealand White) Luthfia Dhiyaul Amalia; Danang Raharjo; Anita Dwi Septiarini
Journal of Educational Innovation and Public Health Vol. 1 No. 4 (2023): Oktober : Journal of Educational Innovation and Public Health
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/innovation.v1i4.1884

Abstract

Cuts are defined as a form of damage or loss of body tissue caused by a sharp object. Incision wounds are also called incision wounds which are a type of acute wound. The method used in this research is an experimental method which aims to determine the presence of wound healing activity of extract and spray gel of nipah leaf extract (Nypa fruticans. Wurmb) as well as test the physical quality of spray gel preparation using New Zealand White (male) rabbits. There were 4 test animals divided into 4 groups, the sample was divided into 4 groups, namely the positive control group with Hansaplast spray and the negative control spray gel preparation without extract, the treatment group Nipah leaf extract gel spray (Nypa fruticans. Wurmb) with extract concentration 2 %,3%,5%. In nipah leaves (Nypa fruticans. Wurmb) there are compounds such as alkaloids, flavonoids, and saponins. This study proved that the ethanol extract of nipah leaves (Nypa fruticans. Wurmb) could be used as an anti-inflammatory, the result was that the ethanol extract gel preparation of nipah leaves (Nypa fruticans. Wurmb) had activity towards wound healing in rabbits
Testing the Tonic Effect of Gotu Kola (Centella asiatica) Extract on Male White Mice (Mus musculus) Using the Rotarod Method Wiwin Novitasari; Anita Dwi Septiarini; Bagas Ardiyantoro
International Journal of Health Engineering and Technology Vol. 4 No. 3 (2025): IJHET SEPTEMBER 2025
Publisher : CV. AFDIFAL MAJU BERKAH

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Abstract

A tonic is a substance or mixture of substances that can strengthen the body or increase a person's energy. The tonic effect is caused by stimulation of the central nervous system (CNS). The herb gotu kola (Centella Asiatica) is a natural substance that contains bioactive compounds such as terpenoids, which play a role in producing the tonic effect. This study aims to analyze the ability of gotu kola herb extract (Centella asiatica) to provide a tonic effect on male white mice (Mus Musculus) and to determine the optimal dose of gotu kola herb extract (Centella Asiatica) to provide an optimal tonic effect. This study used the Rotarod test with treatment groups, each consisting of 5 test animals given Na-CMC 0.5% as a negative control, caffeine 100mg/kgBW as a positive control, and Centella asiatica herb extract suspension at varying doses, namely 50mg/kgBW as a low dose treatment, 100 mg/kgBW as a medium dose treatment, and 150 mg/kgBW as a high dose treatment. Statistical test results showed a significant increase in the time mice remained on the rotarod in all dose treatments compared to the negative control and no treatment. The 150 mg/kgBW dose provided a tonic effect closest to that of caffeine. Phytochemical testing showed that gotu kola herb contains terpenoids, which are thought to play a role in its tonic activity. Thus, gotu kola herb extract has the potential to be developed as a natural tonic alternative.
daun pegagan (Centella Asiatica UJI EFEK DIURETIK EKSTRAK ETANOL 96% DAUN PEGAGAN (Centella Asiatica (L.) Urb) PADATIKUS PUTIH JANTAN GALLUR WISTAR (Rattus Norvegicus) NOVISYIAHGIANT, DINA AMALIA; Anita Dwi Septiarini; Tatiana Siska Wardani
Duta Pharma Journal Vol. 3 No. 2 (2023): Duta Pharma Journal
Publisher : Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/djp.v3i2.3129

Abstract

Pegagan (Centella asiatica (L.) Urb) merupakan bahan alami yang dapat dimanfaatkan oleh masyarakat. Pegagan mengandung senyawa flavonoid yang memiliki efek diuretik dengan mempercepat produksi urin. Penelitian ini bertujuan untuk mengetahui aktivitas diuretik ekstrak pegagan dengan etanol 96% pada tikus jantan. Penelitian ini merupakan penelitian eksperimental dan diekstraksi dengan metode maserasi dalam pelarut etanol 96%. Tikus jantan sebanyak 25 ekor dibagi menjadi 5 kelompok yaitu kelompok kontrol negatif (Na CMC 0,5%), kelompok perlakuan (ekstrak etanol dosis 200, 300 dan 400 mg/KgBB) dan kelompok kontrol positif (spironolakton 1,8mg/kgBB). Uji efek diuretik dilakukan dengan mengukur pengeluaran urin setiap 2 jam selama 6 jam, kemudian data dianalis uji One-way Anova dan dilanjutkan dengan uji Tukey HSD. Hasil penelitian pada ekstrak etanol 96% daun pegagan (Centella asiatica (L.) Urb) dengan variasi dosis 200 mg/kg BB, 300 mg/kg BB, 400 mg/kg BB manunjukkan bahwa mempunyai efek diuretik yang optimal pada kelompok V dengan dosis 400 mg/Kg BB dengan P< 0,05 atau ada perbedaan yang signifikan.
Uji Aktivitas Antiinflamasi Estrak Sirih Cina (Peperomia Pellusida) Pada Tikus Jantan Galur Wistar Yang Diinduksi Karagenan Achmad Fauzi; Anita Dwi Septiarini; Tatiana Siska Wardani
Detector: Jurnal Inovasi Riset Ilmu Kesehatan Vol. 1 No. 3 (2023): Agustus : Jurnal Inovasi Riset Ilmu Kesehatan
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/detector.v1i3.2428

Abstract

Chinese betel plant (Peperomia pellucida), an herbal plant belonging to the Piperaceae family, Chinese betel plant (Peperomia pellucida). Research Stages: sample collection, extract preparation, extract standardization, determination of non-specific parameters, phytochemical screening, preparation of test solutions, anti-inflammatory activity tests, treatment of test animals. The results of maceration were filtered using filter paper, then the entire filtrate was concentrated using a vacuum evaporator and water bath at 60℃ to obtain a thick extract. The yield of 96% ethanol extract from Chinese betel powder (Peperomia pellucida) obtained was 4.531%. Based on the results, it has non-specific characteristics, namely drying shrinkage of 9.26%, ash content of 7.9% and water content of 4.15%. Phytochemical screening the compound tested was positive, A dose of 150 mg/kgBB is also an effective dose in inhibiting the formation of edema seen from the effect it gives is stable and has the highest percentage of edema inhibition compared to other doses, which is 34,35%.
Co-Authors ACHMAD FAUZI Bagas Ardiyantoro Danang Raharjo Luthfia Dhiyaul Amalia NOVISYIAHGIANT, DINA AMALIA Wardani, Tatiana Siska Wiwin Novitasari