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All Journal International Journal of Health, Engineering and Technology Journal of Educational Innovation and Public Health
Anita Dwi Septiarini
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Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Dentistry Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mechanical Engineering Medicine & Pharmacology Nursing Public Health Veterinary

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Formulasi Dan Uji Mutu Fisik Sediaan Spray Gel Ekstrak Etanol Daun Nipah (Nypah fructicans. Wurmb) Sebagai Terapi Pengobatan Luka Sayat Terhadap Kelinci (New Zealand White) Luthfia Dhiyaul Amalia; Danang Raharjo; Anita Dwi Septiarini
Journal of Educational Innovation and Public Health Vol. 1 No. 4 (2023): Oktober : Journal of Educational Innovation and Public Health
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/innovation.v1i4.1884

Abstract

Cuts are defined as a form of damage or loss of body tissue caused by a sharp object. Incision wounds are also called incision wounds which are a type of acute wound. The method used in this research is an experimental method which aims to determine the presence of wound healing activity of extract and spray gel of nipah leaf extract (Nypa fruticans. Wurmb) as well as test the physical quality of spray gel preparation using New Zealand White (male) rabbits. There were 4 test animals divided into 4 groups, the sample was divided into 4 groups, namely the positive control group with Hansaplast spray and the negative control spray gel preparation without extract, the treatment group Nipah leaf extract gel spray (Nypa fruticans. Wurmb) with extract concentration 2 %,3%,5%. In nipah leaves (Nypa fruticans. Wurmb) there are compounds such as alkaloids, flavonoids, and saponins. This study proved that the ethanol extract of nipah leaves (Nypa fruticans. Wurmb) could be used as an anti-inflammatory, the result was that the ethanol extract gel preparation of nipah leaves (Nypa fruticans. Wurmb) had activity towards wound healing in rabbits
Testing the Tonic Effect of Gotu Kola (Centella asiatica) Extract on Male White Mice (Mus musculus) Using the Rotarod Method Wiwin Novitasari; Anita Dwi Septiarini; Bagas Ardiyantoro
International Journal of Health Engineering and Technology Vol. 4 No. 3 (2025): IJHET SEPTEMBER 2025
Publisher : CV. AFDIFAL MAJU BERKAH

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Abstract

A tonic is a substance or mixture of substances that can strengthen the body or increase a person's energy. The tonic effect is caused by stimulation of the central nervous system (CNS). The herb gotu kola (Centella Asiatica) is a natural substance that contains bioactive compounds such as terpenoids, which play a role in producing the tonic effect. This study aims to analyze the ability of gotu kola herb extract (Centella asiatica) to provide a tonic effect on male white mice (Mus Musculus) and to determine the optimal dose of gotu kola herb extract (Centella Asiatica) to provide an optimal tonic effect. This study used the Rotarod test with treatment groups, each consisting of 5 test animals given Na-CMC 0.5% as a negative control, caffeine 100mg/kgBW as a positive control, and Centella asiatica herb extract suspension at varying doses, namely 50mg/kgBW as a low dose treatment, 100 mg/kgBW as a medium dose treatment, and 150 mg/kgBW as a high dose treatment. Statistical test results showed a significant increase in the time mice remained on the rotarod in all dose treatments compared to the negative control and no treatment. The 150 mg/kgBW dose provided a tonic effect closest to that of caffeine. Phytochemical testing showed that gotu kola herb contains terpenoids, which are thought to play a role in its tonic activity. Thus, gotu kola herb extract has the potential to be developed as a natural tonic alternative.
Co-Authors Bagas Ardiyantoro Danang Raharjo Luthfia Dhiyaul Amalia Wiwin Novitasari