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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Pharmaceutical Sciences and Research (PSR) Makara Journal of Health Research Journal of General Procedural Dermatology and Venereology Indonesia
Anggraini, Ita
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Immunology & microbiology Medicine & Pharmacology Public Health

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A Phenotypic Comparison between HIV Positive and HIV Negative Tuberculous Meningitis Patients Anggraini, Ita; Hartantri, Yovita; Rizal, Ahmad
Makara Journal of Health Research Vol. 21, No. 3
Publisher : UI Scholars Hub

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Background: Tuberculous meningitis (TBM) is the most common type of meningitis found in humans and the Human Immunodeficiency Virus (HIV) is a major risk factor of TBM. This study aimed to identify phenotype differences, such as clinical manifestations, cerebrospinal fluid (CSF) findings, and chest x-ray results between HIV positive and HIV negative TBM patients. Methods: This was a comparative analytical study of 123 TBM patients. The patients were divided into two groups based on their HIV status, and their phenotypes were compared. A retrospective cross sectional designed study was carried out in case report form using a TBM cohort and Rifampicin dose finding study in the neurological ward at the Dr. Hasan Sadikin General Hospital Bandung, between January 2015 and August 2016. Categorical data was analysed using Chi square tests and the alternative Fisher’s Exact test and Mann-Whitney test was used for numerical data. P-values were significant if p < 0.05. Results: Of the phenotypic parameters, only the CSF results had statistical difference. HIV positive subjects had higher CSF to blood glucose ratios (0.42 vs. 0.18; p = 0.001) and fewer leukocyte cells (41 vs. 199; p < 0.001). Conclusions: CSF findings of TBM patients’ revealed differences between HIV positive and negative patients, whilst clinical manifestations and chest x-ray results showed no differences.
Subchronic Toxicity Study of Sterculia rubiginosa Zoll. Ex Miq. Leaves Extract Prastiwi, Rini; Hidayati, Ester; Anggraini, Riska; Mauliza, Cut; Anggraini, Ita; Dewanti, Ema
Pharmaceutical Sciences and Research Vol. 10, No. 3
Publisher : UI Scholars Hub

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Ki hampelas (Sterculia rubiginosa Zoll. Ex Miq.) is traditionally used as an antiasthma. It also reported has antioxidant and nephroprotective activity. This study was conducted to evaluate the subchronic toxicity of the leaf extract of ki hampelas. The extract was orally administered to male and female Sprague-Dawley rats at doses of 50, 200, and 400 mg/kg bodyweight (BW) per day for 28 days. The rats were divided into four groups, consist of consist of normal group (Na CMC 0.5%), dose 1 (50 mg/kg BW), dose 2 (200 mg/kg BW), and dose 3 (400 mg/ kg BW) of extract. The extract was administered every day for 28 days. Subchronic toxicity in the male and female rats resulted in no death or treatment-related signs at the highest dose. All the animals survived the duration of the study, with no significant changes in biochemical parameters and there was a change in the liver and kidney histopathology results. There was no significant difference between the SGOT, SGPT, urea, and creatinine levels in the dose groups with extracts and the normal group (p > 0.05). However, based on the histological results of the liver and kidneys it was found a significant difference among the groups. This study showed that the leaf extract of ki hampelas is relatively non-toxic according to the normal biochemical parameters results and has no treatment-related signs. There was a change in the liver and kidney histopathology results, but no death was found.
Factors Associated with the Severity of Erythema Nodosum Leprosum Reactions Anggraini, Ita; Esti, Prima Kartika; Komarasari, Eka
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 9, No. 1
Publisher : UI Scholars Hub

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Background: Leprosy is a chronic infection caused by Mycobacterium leprae. Leprosy reactions, including erythema nodosum leprosum (ENL), are induced by immune responses. ENL can cause neurological damage and deformities that result in disabilities. This study aimed to identify factors associated with the severity of ENL to help control the leprosy reactions. Methods: This was an analytical study on 148 patients with ENL reactions, who were divided into two groups based on the severity of their reactions. A retrospective cross–sectional study was conducted in the medical record unit of Sitanala Hospital, Tangerang, Banten, Indonesia, from May 2022 to April 2024. Data evaluated included age, gender, leprosy types, treatment status, duration of illness, clinical manifestations, involvement of other organs, disability, comorbidities, acid-fast bacilli, and laboratory examination. Categorical data was analyzed with chi-square test or Fisher’s exact test, and numerical data was analyzed with the Mann-Whitney test. Significance is determined at p < 0.05. Results: Characteristics including age, neuritis, skin ulcers, and comorbidities differ significantly between mild and severe ENL (p = 0.034; < 0.001; < 0.001; and 0.003, respectively). Severe ENL reactions tend to occur more frequently in older patients, and is associated with higher bacterial index (p = 0.004) and lower sodium and albumin levels (p = 0.014 and < 0.001, respectively). Conclusion: Age, neuritis, skin ulcer, comorbidities, bacterial index, as well as sodium and albumin levels were associated with the severity of ENL reactions. Appropriate management is required to prevent further complications.
Combination of 1064 nm QS Nd:YAG Photoacoustic Technology and Exosome for Facial Rejuvenation Setiawan, Stanley; Putranto, Samuel Septrian; Linata, Angela Maria; Salim, Stephanie; Mertosono, Novia Sari Andriati; Nobel, Shelly; Wardianti, Flora Asri; Anggraini, Ita; Rahmawati, Zulaikha Rizqina
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 9, No. 1
Publisher : UI Scholars Hub

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Background: Facial rejuvenation has become a global trend in cosmetic and aesthetic dermatology to restore youthful skin. The combination of 1064 nm Q-Switched Neodymium:Yttrium Aluminum Garnet (QS Nd:YAG) laser and exosomes as a facial rejuvenation procedure restores youthfulness by increasing collagen and elastin. Case Illustration: This case series evaluated the effectiveness of 1064 nm QS Nd:YAG laser with and without human amniotic fluid stem cell-derived exosomes (hAFSC-exo) for facial rejuvenation in six adults aged 24–39 years with Fitzpatrick skin types III-IV. Participants were randomized to receive either laser treatment alone or combined with intradermal hAFSC-exo injections every two weeks for three sessions, with outcomes assessed through blinded objective and subjective evaluations. Objective assessments using a skin analyzer showed improvements for both groups, with consistently greater improvement in the combination therapy group. Meanwhile, subjective evaluations using the GAIS scale indicated that combination therapy recipients experienced “very much improved” outcomes, minimal side effects, and good overall tolerance. Discussion: Facial rejuvenation using 1064 nm QS Nd:YAG laser and hAFSC-exo was evaluated in this case series. Both treatments improved skin quality, but combination therapy demonstrated superior results. However, improvements in pigmentation were limited, and subjective assessments may have been influenced by response bias. The short follow-up period limited the evaluation of long-term skin changes; extended studies are warranted to assess sustained outcomes. Conclusion: Combination therapy of 1064 nm QS Nd:YAG laser and exosomes has a favorable result for facial rejuvenation.
The Association of Gut Microbiomes in Skin Cancer: Systematic Review and Meta–analysis Anggraini, Ita; Esti, Prima Kartika; Komarasari, Eka
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 38 No. 1 (2026): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikkk.V38.1.2026.55-65

Abstract

Background: The popularity of using probiotics to treat various diseases, including skin conditions, has been on the rise. It is widely recognized that skin cancer results from the uncontrolled growth of tumor cells, initiated by multiple contributing factors. Emerging research indicates that alterations in the gut microbiome may also play a role in the incidence of skin cancer. Purpose: This study was conducted to evaluate the relationship between gut microbiomes and skin cancer. Methods: This systematic review was conducted using the PubMed, ScienceDirect, and Cochrane Library databases for original articles published from 2015 to 2025. The focus of the study was the association of gut microbiomes in skin cancer. Then, the selected studies would be assessed for eligibility using the JBI critical appraisal, bias risk using RevMan tools, and meta-analysis using forest plotsesult: Of five studies, 261 subjects met the inclusion criteria. The combined odds ratio (OR) found in this study was 2.81, with a 95% confidence interval (CI) ranging from 1.97 to 3.99. According to the forest plot, there was a statistically significant overall effect observed (Z = 5.74; p < 0.00001), indicating a strong and meaningful association of the investigated variable. Although the studies related to the association of gut microbiomes in skin cancer were still limited, most of them showed similar results. Conclusion: There is an association of gut microbiomes in skin cancer. This study could lead to novel therapeutic strategies, where modulating the gut microbiome becomes a skin cancer treatment and prevention plan
Co-Authors ahmad rizal Ema Dewanti Esti, Prima Kartika Hidayati, Ester Komarasari, Eka Linata, Angela Maria Mauliza, Cut Mertosono, Novia Sari Andriati Nobel, Shelly Putranto, Samuel Septrian Rahmawati, Zulaikha Rizqina Rini Prastiwi Riska Anggraini, Riska Salim, Stephanie Setiawan, Stanley Wardianti, Flora Asri Yovita Hartantri