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All Journal Althea Medical Journal The Indonesian Biomedical Journal Belitung Nursing Journal Makara Journal of Health Research Jurnal Penyakit Dalam Indonesia
Yovita Hartantri
Department Of Internal Medicine, Faculty Of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Bandung 40161
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Nursing Public Health

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A Phenotypic Comparison between HIV Positive and HIV Negative Tuberculous Meningitis Patients Anggraini, Ita; Hartantri, Yovita; Rizal, Ahmad
Makara Journal of Health Research Vol. 21, No. 3
Publisher : UI Scholars Hub

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Background: Tuberculous meningitis (TBM) is the most common type of meningitis found in humans and the Human Immunodeficiency Virus (HIV) is a major risk factor of TBM. This study aimed to identify phenotype differences, such as clinical manifestations, cerebrospinal fluid (CSF) findings, and chest x-ray results between HIV positive and HIV negative TBM patients. Methods: This was a comparative analytical study of 123 TBM patients. The patients were divided into two groups based on their HIV status, and their phenotypes were compared. A retrospective cross sectional designed study was carried out in case report form using a TBM cohort and Rifampicin dose finding study in the neurological ward at the Dr. Hasan Sadikin General Hospital Bandung, between January 2015 and August 2016. Categorical data was analysed using Chi square tests and the alternative Fisher’s Exact test and Mann-Whitney test was used for numerical data. P-values were significant if p < 0.05. Results: Of the phenotypic parameters, only the CSF results had statistical difference. HIV positive subjects had higher CSF to blood glucose ratios (0.42 vs. 0.18; p = 0.001) and fewer leukocyte cells (41 vs. 199; p < 0.001). Conclusions: CSF findings of TBM patients’ revealed differences between HIV positive and negative patients, whilst clinical manifestations and chest x-ray results showed no differences.
Cause of The Low Positivity of Blood Culture in Septic Patients Yana, Krishna; Alisjahbana, Bachti; Hartantri, Yovita
Jurnal Penyakit Dalam Indonesia Vol. 5, No. 4
Publisher : UI Scholars Hub

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Introduction. Sepsis due to bacterial infection is one of the main causes of high disease morbidity and mortality. Management of sepsis, the detection of bacteriemia by examination of blood cultures has an important role, but until now the positivity of blood culture results at Hasan Sadikin Hospital (RSHS) is still low (13.45%). The purpose of this study was to determine profile the causes of low positivity of blood culture results in sepsis patients in RSHS. Methods. A cross sectional study was conducted on sepsis patient treated in Emergency Un it (ER) and inpatient of Hasan Sadikin hospital Internal Medicine from December 2016 until April 2017. This study collects patient clinical information, laboratory, history Administration of antibiotics, and techniques of examination of bacterial blood cultures in sepsis patients. Results. During the study period 179 subjects were obtained. The subject mainly uses the Health Guarantee Agency (BPJS) for financing. The positivity of blood cultures was found to be 24%. The mean leukocyte count on positive blood culture results was 18,100 / mm3 and there were 79.07% cultures with Neutrofil Limfosit Count Ratio (NLCR) >10. The time for taking blood cultures is mainly done at> 6 hours after admission. The number of blood cultures is taken at least once. The amount of blood volume in each culture tube is mostly 5 cc. Taking blood cultures is mainly carried out by competent nurses who have not received blood culture taking training. Conclusions. The positive results of blood culture in septic patients in RSHS are still low. Taking blood cultures should be carried out in accordance with the guidelines, which consist of not giving antibiotics before taking blood culture, taking blood time at admission, the number of blood taken for culture >1 time, the amount of blood volume in a culture tube is at least 10 cc, use 2 types of antiseptics, the use of antiseptics on culture bottle caps, the time lag between antiseptic action and blood collection for culture. It is necessary to monitor the factors that influence the positivity of blood cultures in septic patients. Researchers also recommend training and policy improvements to improve blood culture positivity.
Infeksi Oportunistik pada Pasien HIV yang Dirawat Inap di RSUP Dr. Hasan Sadikin Bandung Tahun 2019-2022 Salma, Katarina; Hartantri, Yovita; Fauziah, Nisa
Jurnal Penyakit Dalam Indonesia
Publisher : UI Scholars Hub

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Introduction. Human Immunodeficiency Virus (HIV) is a virus that infects and attacks the human immune system. The high morbidity and mortality rates in HIV patients can be attributed to various factors, one of which is the presence of opportunistic infections due to the weakened immune response, making HIV patients highly susceptible to other infections. This study aims to provide an overview of opportunistic infections in HIV patients hospitalized at Dr. Hasan Sadikin General Hospital in Bandung within the period of 2019-2022. Methods. This descriptive observational study was conducted on 255 HIV patients with opportunistic infections who were hospitalized at dr. Hasan Sadikin Hospital (RSHS), Bandung. The study utilized secondary data from medical records from 2019 to 2022. The sampling method employed in this research was total sampling. Data processing and analysis of the relationship between two variables, namely the number of opportunistic infections and length of hospital stay, with HIV stage, were performed using IBM SPSS Statistics software version 26. The statistical methods used in this analysis included the Chi-square test and the Mann-Whitney test. Results. The research findings indicated that the most common opportunistic infection in HIV patients was oral candidiasis (60,0%), followed by pulmonary tuberculosis (453,1%) and toxoplasmosis (45,136,5%). The prevalence of opportunistic infections was higher in males (79,2%) compared to females. The age group most affected was patients aged 24-44 years. There was also a significant association between the HIV stage and the number of opportunistic infections, with a higher number of opportunistic infections occurring in patients with stage 4 HIV. Conclusions. Oral candidiasis and tuberculosis are opportunistic infections with the highest prevalence among HIV patients who were hospitalized at dr. Hasan Sadikin Hospital during the period of 2019-2022.
Retention in HIV care among Southeast Asian people living with HIV: A systematic review and meta-analysis Maulana, Sidik; Ibrahim, Kusman; Pramukti, Iqbal; Amirah, Shakira; Hartantri, Yovita
Belitung Nursing Journal Vol. 11 No. 3 (2025): May - June
Publisher : Belitung Raya Foundation, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33546/bnj.3719

Abstract

Background: Despite the effectiveness of antiretroviral therapy (ART) in reducing HIV-related morbidity and mortality, the retention of HIV care remains suboptimal in Southeast Asia. Objective: This systematic review and meta-analysis aimed to investigate the coverage of retention in care and the likelihood factors for retention in HIV care among Southeast Asian people living with HIV, to inform targeted interventions and policy improvements. Methods: Following the Preferred Reporting Item for Systematic Review and Meta-analysis (PRISMA) guidelines, this study included observational studies reporting factors associated with retention in HIV care among Southeast Asian adults, with searches conducted in PubMed, Scopus, Cochrane Library, and CINAHL up to July 15, 2024. Demographic and clinical factors were analyzed using a random-effects model with the generalized linear mixed-effect model (GLLM) to estimate proportion and the DerSimonian-Laird method to estimate odds ratios (OR) with 95% confidence intervals (CI), assessing heterogeneity using the I² statistic. Results: Among the eleven studies with 46,480 pooled participants analyzed, the coverage of retention in care revealed a pooled proportion of 75.2% (95% CI: 66.7-82.1). Significant clinical factors associated with a higher likelihood of retention included high CD4 count (≥200 cells/mm³) (OR 2.17 (95%CI: 1.19-3.97, p = 0.01), WHO stage 3-4 (OR 2.06, 95%CI: 1.09-3.87, p = 0.02), not being on ART (OR 6.88, 95%CI: 1.89-25.06, p = 0.001), hemoglobin levels ≥10 g/dL (OR 0.50, 95% CI: 0.25-0.99, p = 0.04), and demographic factors of employment (OR 1.18, 95% CI: 1.02-1.38; p = 0.03). Other clinical factors, such as HIV stage, TB co-infection, drug abuse/substance use, and hemoglobin levels, did not significantly affect the likelihood of retention. Similarly, demographic factors such as age, gender, education, marital status, and geographic setting also showed no significant impact on likelihood retention. Conclusion: Retention in care among Southeast Asian people living with HIV was still below 95%. Clinical factors, particularly high CD4 counts, WHO stage, and the absence of ART, were likelihood factors for retention in HIV care, whereas other clinical and demographic factors studied did not show a significant impact. A universal test and treatment strategy is required to improve retention in care.
Systemic Immune-Inflammation Index as a Potential Indicator of COVID-19 Severity in a Tertiary Hospital in Indonesia Hamdan, Angkasa Ramatuan; Fianza, Pandji Irani; Hartantri, Yovita
Althea Medical Journal Vol 12, No 3 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n3.4238

Abstract

Background: The progression of coronavirus disease 2019 (COVID-19) to severe stages is strongly influenced by host immunity and inflammatory. The Systemic Immune-Inflammation Index (SII) is a novel biomarker reflecting both immunity and inflammation. This study aimed to analyze differences in SII according to COVID-19 severity.Methods: A cross-sectional study was conducted using medical records of COVID-19 patients hospitalized at Dr. Hasan Sadikin General Hospital, Bandung, Indonesia, between March 2020 and August 2021. SII was calculated as the absolute neutrophil count and platelet count divided by the absolute lymphocyte count obtained from peripheral blood samples. COVID-19 severity was classified based on oxygen saturation (SpO₂). Receiver operating characteristic (ROC) curve and the area under the curve (AUC) were used to evaluate the discriminatory ability of SII. Results: Of the 1,192 patients included, 410 (34.3%) had severe symptoms and 782 (65.7%) had mild to moderate symptoms. The median SII at admission was significantly higher in severe symptoms [1779 x 109 /L (IQR 46-40416)] compared with mild to moderate symptoms [880 x 109 /L (IQR 14.5-23280)]; p<0.001. ROC analysis showed an SII cut-off of 1244 with an AUC of 0.695 (95% CI 0.668–0.721), sensitivity 65.9%, and specificity 66.2%.Conclusions: SII may serve as a potential biomarker for predicting COVID 19 severity. Its simplicity and availability from routine blood counts make it particularly valuable for early risk stratification, especially in resource-limited settings. Moreover, early recognition of elevated SII could support timely interventions, prevent disease progression, and improve clinical outcomes.
The Combination of Gardenia jasminoides, Boswellia serrata, Commiphora myrrha, Foeniculum vulgarae, and Daucus carota Essential Oil Blend Improved the Inflammatory and Clinical Status in Respiratory Tract Infection of COVID-19 Patients: A Multicentre, Randomized, Open-label, Controlled Trial Lestari, Keri; Babikian, Haig; Kulsum, Iceu Dimas; Ferdian, Ferdy; Ismail, Efriadi; Sumalim, Yelsen; Setiawan, Setiawan; Santoso, Prayudi; Hartantri, Yovita; Arifin, Arief Riadi; Meiliana, Anna; Sormin, Ida Paulina; Sugiono, Erizal
The Indonesian Biomedical Journal Vol 16, No 3 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i3.3023

Abstract

BACKGROUND: Essential oils (EO) are complex volatile, naturally synthesized compounds from aromatic plants. It considers as healthy, effective, and safe since they were coming from nature. Gardenia jasminoides, Boswellia serrata, Commiphora myrrha, Foeniculum vulgarae, and Daucus carota are known to have antimicrobials, antioxidants, antiinflammation properties against respiratory tract infection. However, despite its natural content, a safety profile needs to be observed. Therefore, in this study, EO blend (EOB) made from the combination of these 5 plants was assessed for its efficacy and safety for respiratory tract infection in human.METHODS: A multicentre, randomized, open-label, phase II controlled trial involving 80 hospitalized adults with COVID-19 was conducted. One group of subjects only received standard of care (SoC), while the other group receive SoC and EOB orally for 10 days.RESULTS: There were significant decrease in interleukin (IL)-6 level (p=0.016) and interferon (IFN)-γ level (p=0.012), as well as better respiratory rate (p=0.024) for the group receiving SoC and EOB compared to the group receiving SoC only. However, there was no significant differences in aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine, and the corrected QT interval (QTc) prolongation value in both groups. All subjects with adverse effects were improved and recovered, and there were no serious adverse events found.CONCLUSION: The combination of G. jasminoides, B. serrata, C. myrrha, F. vulgarae, and D. carota EOB could improve the inflammatory and clinical status and safe to be used as adjuvant therapy for treating COVID-19 in adults.KEYWORDS: essential oils, COVID-19, inflammation, safety
Co-Authors Ahmad Rizal ahmad rizal Amirah, Shakira Anggraini, Ita Anna Meiliana Arifin, Arief Riadi Babikian, Haig Bachti Alisjabana, Bachti Bachti Alisjahbana Bony Wiem Lestari Dinka Anni Zamy Erizal Sugiono, Erizal Fauziah, Nisa Ferdy Ferdian Hamdan, Angkasa Ramatuan Iceu Dimas Kulsum Ida Parwati Ida Paulina Sormin Iqbal Pramukti Ismail, Efriadi Ita Anggraini Juniati, Rianita Keri Lestari Krishna Yana Kusman Ibrahim Maulana, Sidik Nataprawira, Heda M Pandji Irani Fianza Prayudi Santoso Rudi Wisaksana Salma, Katarina Setiawan Setiawan Soeroto, Arto Y Sumalim, Yelsen Yana, Krishna