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All Journal Makara Journal of Health Research
Tg Zakaria, Tg M
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Cytotoxic and Anti-Inflammatory Activities of Garcinia xanthochymus Extracts on Cell Lines Hamidon, Hanisuhana; Taher, Muhammad; Jaffri, Juliana M; Tg Zakaria, Tg M; Sulaiman, Wan MAW; Susanti, Deny; Ichwan, Solachuddin JA; Zakaria, Zainul A
Makara Journal of Health Research Vol. 20, No. 1
Publisher : UI Scholars Hub

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Abstract

Background: Garcinia xanthochymus extract has been reported to have several pharmacological properties. This study was conducted to evaluate cytotoxic and anti-inflammatory activities of G. xanthochymus extracts on cell lines. Methods: The roots and stem barks of plant were extracted using maceration method with n-hexane, dichloromethane and methanol, successively. Cytotoxic activity of the extracts was tested against MCF-7 breast adenocarcinoma using MTT assay. Anti-inflammatory study was evaluated using RAW 264.7 mouse macrophage cells. The nitric oxide production in LPS-stimulated cells was measured using Griess reagent. Results: The results of cytotoxic and anti-inflammatory study showed that dichloromethane and n-hexane extracts of root and stem bark exhibited cytotoxic activity in dose-dependent manner. Meanwhile, for anti-inflammatory study, all root extracts together with stem bark dichloromethane and n-hexane extracts reduce NO production in LPS-stimulated cells in dose dependent manner. Conclusions: This finding indicated that G. xanthochymus extracts might become interesting candidate for treatment of cancer and inflammation.
Co-Authors Daniel Happy Putra Hamidon, Hanisuhana Ichwan, Solachuddin JA Jaffri, Juliana M Sulaiman, Wan MAW Taher, Muhammad Zakaria, Zainul A