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All Journal Jurnal Farmasi Sains dan Praktis
Irma Irma
Universitas Halu Oleo, Indonesia
Immunology & microbiology Medicine & Pharmacology Public Health

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ANTIINFLAMMATORY EFFECTS OF FRACTION FROM GALING STEM ETHANOL EXTRACT (Cayratia trifolia L. Domin) IN VITRO Muhammad Ilyas Y; Muhammad Syaiful Saehu; Ertin Ertin; Irma Irma; Nurhikma Nurhikma
Jurnal Farmasi Sains dan Praktis Vol 7 No 3 (2021): Supplementary Issue (The 4th National Pharmacy Conference 2021 Universitas Halu O
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i3.6107

Abstract

Galing plant (Cayratia trifolia L. Domin) is a wild plant that spreads and is easily found in Indonesia, especially in the lowlands, which contains a class of secondary metabolites such as flavonoids, polyphenols, alkaloids, terpenoids, and triterpenoids with various pharmacological activities such as antidiabetic, immunomodulatory, antibacterial, anti-fungal, anti-diarrhea, gout. This study aims to determine the antiinflammatory effect of several fractions of rod galing using the in vitro model of red blood cell membrane stabilization. This study used an ethanol extract fractionated in a liquid-liquid manner with n-hexane, ethyl acetate, and water as a solvent. Then, the anti-inflammatory effect of each fraction was tested, with a positive control comparison of diclofenac sodium with varying concentrations. Measurement of anti-inflammatory activity was calculated based on the % stability of the red blood cell membrane. The results showed that the ethyl acetate, n-hexane and water fractions from the ethanol extract of galing (Cayratia trifolia L. Domin.) stem had an anti-inflammatory effect based on the % stability of red blood cell membranes, where the ethyl acetate fraction with a concentration of 1000 ppm had the best anti-inflammatory effect with % stability of red blood cell membranes was 91.81%, which was significantly different from the positive control (p<0.05).
CASE STUDY OF POSITIVE CONFIRMED MALARIA IN SOUTHEAST SULAWESI BASED ON EPIDEMIOLOGICAL VARIABLES Irma Irma; Yusuf Sabilu
Jurnal Farmasi Sains dan Praktis Vol 7 No 3 (2021): Supplementary Issue (The 4th National Pharmacy Conference 2021 Universitas Halu O
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i3.6143

Abstract

Malaria is one of the most common mosquito-borne infectious diseases in the world. Globally, deaths due to malaria infection reported in 2019 amounted to 405,000 deaths with a total number of sufferers of around 228 million cases. Although malaria cases have continued to decline in the last five years, including in Southeast Sulawesi Province, there are still regencies/cities in Southeast Sulawesi that have not been free from malaria. Therefore, this disease continues to be a burden of pain. This study aims to describe malaria cases in Southeast Sulawesi during the period from 2016 to 2020 based on epidemiological variables, namely people, place and time. The results showed that in general malaria cases from 2016 to 2020 showed a significant decline, based on place it can be seen that the Muna district was the area with the highest prevalence of malaria throughout the year of observation and North Konawe District as the area with the lowest malaria prevalence. From the people variable, the majority (67%) of malaria cases were men and only 33% were women. Meanwhile, based on the time in five years of observation, the highest malaria prevalence occurred in 2016 and the lowest was in 2020. Malaria prevention and control programs need to be carried out strictly to support the achievement of malaria elimination in all districts and cities in Southeast Sulawesi.
EPIDEMIOLOGICAL ANALYSIS OF TRENDS IN DHF CASES IN MALANG CITY Swaidatul Masluhiya AF; Irma Irma
Jurnal Farmasi Sains dan Praktis Vol 7 No 3 (2021): Supplementary Issue (The 4th National Pharmacy Conference 2021 Universitas Halu O
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i3.6146

Abstract

Dengue Hemorrhagic Fever (DHF) is a disease caused by a virus which is still a public health problem whose number of sufferers is getting higher and its area of distribution is expanding which can cause death. DHF is also still endemic and continues to spread throughout the city of Malang. This research is descriptive qualitative research that aims to see the tendency of DHF cases in Malang City based on the variables of person, place and time of occurrence. The population and samples used were all data on DHF patients in Malang City which were obtained from the Malang City Health Office for the period 2015 - 2020 as many as 1.717 cases. The results of the data analysis of this study indicate that cases of DHF in Malang City always experience an increase from January to June with the highest peak in May every year, mostly 34.8% of DHF cases occur in Lowokwaru District and the majority (54.62%) are women and most (51.81%) are in the age group 15-44 years. There is a need for maximum prevention and control of dengue fever, especially before the increase in cases at the beginning of the year, especially in the Lowokwaru District which is the work area of the Dinoyo Public Health Center, Kendalsari and Mojolangu.
Co-Authors Ertin Ertin Muhammad Ilyas Y Muhammad Syaiful Saehu Nurhikma Nurhikma Yusuf Sabilu