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Maruni Wiwin Diarti
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Variasi Dosis Spray Ekstrak Etanol Solanum melongena L. dan Cananga adorata terhadap Perubahan Gejala Toksik, Fungsi Hepar, dan Hispatologi Mencit (Mus musculus) Zainal Fikri; Yunan Jiwintarum; Maruni Wiwin Diarti; Hady Anshory Tamhid
Jurnal Kesehatan Manarang Vol 8 No 2 (2022): Agustus 2022
Publisher : Politeknik Kesehatan Kemenkes Mamuju

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33490/jkm.v8i2.656

Abstract

The purpose of this study was to determine toxic symptoms (loss of reflex), enzyme activity of SGOT and SGPT, and liver histopathology of experimental mice (Mus musculus) exposed to a combination formulation of 96% ethanol extract spray of Solanum melongena L. and Cananga adorata flower oil. True experimental research design with Post Test Only Control Group Design, this study used 4 treatment groups and 1 control group, data collected in the form of toxic symptoms (loss of reflex), SGOT enzymatic activity, and liver histopathological picture of experimental mice (Mus musculus). Which was analyzed by One Way Anova and Descriptive test. The results showed that the changes in toxic physical symptoms (loss of reflexes) of experimental mice (Mus musculus) after 30 minutes of spraying were strange reactions to walking around without direction, sensitivity to touch, changes in social interaction colliding with each other, lethargy, eye opacity and excessive blinking, respiratory rate. increased, which returned to normal at 4 hours to 168 hours after spraying. The activity of the SGOT and SGPT enzymes after 168 hours of spraying showed that the higher the dosage of the formulation, the higher the activity of the SGOT and SGPT enzymes, but the increase was still within normal limits, the histopathological results of liver morphology grading at various research doses showed Normal and Mild. Conclusion: Solanum melongena L. and Cananga adorata flower oil combined did not cause pathological effects in experimental mice (Mus musculus).
Kadar Ureum, Kreatinin, Serum Iron (SI) dan Total Iron Binding Capacity (TIBC) pada Pasien Chronic Kidney Disease (CKD) sebelum dan setelah Hemodialisis Pancawati Ariami; Siti Zaetun; Aan Gunaifi; Maruni Wiwin Diarti
Jurnal Analis Medika Biosains (JAMBS) Vol 9, No 2 (2022): JURNAL ANALIS MEDIKA BIOSAINS (JAMBS)
Publisher : Poltekkes Kemenkes Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32807/jambs.v9i2.279

Abstract

Tujuan  penelitian ini adalah untuk mengetahui kadar ureum, kreatinin, SI (serum iron) dan TIBC dalam darah sebelum dan sesudah hemodialisis. Jenis penelitian ini obervasional deskriptif.  Populasi dalam penelitian ini adalah keseluruhan pasien CKD RSUD Kota Mataram yang melakukan Hemodialisis. Sampel dalam penelitian ini menggunakan serum  pasien CKD yang melakukan Hemodialisis. Besar sampel 46 responden, Data  yang dikumpulkan kadar ureum, kreatinin, SI (serum iron) dan TIBC pada pasien CKD di RSUD Kota Mataram dianalis menggunakan uji Wilcoxon signed Rank Test pada tingkat kepercayaan 95% p α = 0,05. Hasil penelitian menunjukkan rerata kadar ureum, kreatinin, SI (serum iron) dan TIBC pada pasien CKD sebelum melakukan  hemodialisis berturut-turut sebesar 133,3 mg/dL ; 8,86 mg/dL ; 65,2 µg/dL ; dan 259,7 µg/dL. Rerata kadar ureum, kreatinin, SI (serum iron) dan TIBC pada pasien CKD setelah melakukan  hemodialisis berturut-turut sebesar 66,6 mg/dL ; 4,51 mg/dL ; 40,4 µg/dL ; dan 203,8 µg/dL. Kesimpulan hemodialisis berpengaruh terhadap kadar ureum, kreatinin, SI (serum iron) dan TIBC pada pasien CKD.
Variasi Dosis Spray Ekstrak Etanol Solanum melongena L. dan Cananga adorata terhadap Perubahan Gejala Toksik, Fungsi Hepar, dan Hispatologi Mencit (Mus musculus) Zainal Fikri; Yunan Jiwintarum; Maruni Wiwin Diarti; Hady Anshory Tamhid
Jurnal Kesehatan Manarang Vol 8 No 2 (2022): Agustus 2022
Publisher : Politeknik Kesehatan Kemenkes Mamuju

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33490/jkm.v8i2.656

Abstract

The purpose of this study was to determine toxic symptoms (loss of reflex), enzyme activity of SGOT and SGPT, and liver histopathology of experimental mice (Mus musculus) exposed to a combination formulation of 96% ethanol extract spray of Solanum melongena L. and Cananga adorata flower oil. True experimental research design with Post Test Only Control Group Design, this study used 4 treatment groups and 1 control group, data collected in the form of toxic symptoms (loss of reflex), SGOT enzymatic activity, and liver histopathological picture of experimental mice (Mus musculus). Which was analyzed by One Way Anova and Descriptive test. The results showed that the changes in toxic physical symptoms (loss of reflexes) of experimental mice (Mus musculus) after 30 minutes of spraying were strange reactions to walking around without direction, sensitivity to touch, changes in social interaction colliding with each other, lethargy, eye opacity and excessive blinking, respiratory rate. increased, which returned to normal at 4 hours to 168 hours after spraying. The activity of the SGOT and SGPT enzymes after 168 hours of spraying showed that the higher the dosage of the formulation, the higher the activity of the SGOT and SGPT enzymes, but the increase was still within normal limits, the histopathological results of liver morphology grading at various research doses showed Normal and Mild. Conclusion: Solanum melongena L. and Cananga adorata flower oil combined did not cause pathological effects in experimental mice (Mus musculus).
Co-Authors Aan Gunaifi Pancawati Ariami Siti Zaetun Tamhid, Hady Anshory Yunan Jiwintarum Zainal Fikri