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All Journal Jurnal Ilmiah Farmasi EKSAKTA: Journal of Sciences and Data Analysis Majalah Obat Tradisional Jurnal Kesehatan Manarang JURNAL EDUCATION AND DEVELOPMENT JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Ners Jurnal Farmasi dan Sains Indonesia (JFSI) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Tamhid, Hady Anshory
Department Of Pharmacy, Faculty Of Mathematics And Natural Sciences, Universitas Islam Indonesia, Yogyakarta, Indonesia
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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DAYA ANTI QUORUM SENSING EKSTRAK DAUN KAYU MANIS (Cinnamomun burmannii Ness. Ex Bl.) TERHADAP Pseudomonas aeruginosa Hertiani, Triana; Apriliany, Fitri; Anshory, Hady
Majalah Obat Tradisional Vol 18, No 3 (2013)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (176.649 KB) | DOI: 10.14499/mot-TradMedJ18iss3pp173-177

Abstract

Quorum sensing adalah sistem komunikasi antar sel bakteri. Perkembangan biofilm diatur oleh quorum sensing. Biofilm dapat melindungi bakteri dari kerusakan akibat antibiotik sehingga konsentrasi antibiotik harus ditingkatkan 100 sampai 1000 kali lipat. Penghambatan quorum sensing diharapkan dapat mencegah pembentukan biofilm. Kulit kayu manis (Cinnamomum burmanii Ness. Ex Bl.) memiliki aktivitas antibakteri dan antibiofilm. Ketersediaan daun yang melimpah menyebabkan dilakukan penelitian untuk mengetahui apakah daun kayu manis memiliki daya anti quorum sensing terhadap Pseudomona aeruginosa. Serbuk kering daun kayu manis dimaserasi bertingkat berturut-turut menggunakan n-heksana, etil asetat dan metanol. Setelah masing-masing ekstrak dievaporasi, daya antibakteri diamati dengan metode mikrodilusi menggunakan penambahan MTT. Ekstrak yang aktif diamati  daya anti quorum sensing nya dengan metode difusi pada cetrimide Agar.  Aktivitas antiquorum sensing ditunjukkan dengan daerah buram di bawah sinar UV 366 nm. KLT-bioautografi dilakukan untuk mengetahui senyawa yang aktif dalam fraksi tersebut dengan menggunakan fase diam silika gel F254, fase gerak kloroform-metanol  (6:1 v/v), loading sampel sebanyak 1,25 mg dan waktu kontak lempeng dengan medium selama 30 menit. Penelitian menunjukkan bahwa fraksi etil asetat memiliki aktivitas antibakteri terhadap P. aeruginosa dengan nilai KHM 8 mg/mL. Aktivitas penghambatan quorum sensing dan pertumbuhan ditunjukkan pada loading samples 12,5 dan 25 mg/sumuran, sedangkan pada 6,25 mg ekstrak hanya menunjukkan aktivitas penghambatan quorum sensing. Keberadaan senyawa yang memiliki gugus fungsi fenolik, flavonoid, alkaloid dan aldehid/keton terdeteksi dengan metode KLT tetapi tidak terdeteksi bercak aktif pada bioautografi.
Aktivitas ampisilin terhadap bakteri MRSA setelah dikombinasi dengan uap minyak kayu manis menggunakan metode kontak Hady Anshory Tamhid; Arde Toga Nugraha; Aditya Fadilah
Jurnal Ilmiah Farmasi Vol. 13 No. 2 (2017): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol13.iss2.art4

Abstract

Intisari Latar belakang: Resistensi bakteri terhadap antibiotik telah mendorong dilakukan berbagai upaya  penelitian untuk mencari alternatif pengganti antibiotik yang lebih baik. Namun penelitian untuk mencari antibiotik yang baru menghabiskan waktu dan biaya yang tidak sedikit. Bakteri MRSA (Methicillin ResistantStaphylococcus aureus) merupakan salah satu bakteri yang resisten terhadap antibiotik golongan penisilin termasuk ampisilin. Kombinasi antibiotik dengan minyak atsiri dapat menjadi pilihan alternatif untuk mengatasi resistensi bakteri terhadap antibiotik.Tujuan: Penelitian ini bertujuan untuk mengetahui aktivitas antibiotik ampisilin terhadap bakteri MRSA setelah dikombinasi dengan minyak atsiri kulit batang kayu manis (Cinnamomum burmannii)Metode: Minyak atsiri kulit batang kayu manis (KKM) diisolasi menggunakan metode destilasi uap-air dan diidentifikasi komponenya menggunakan GC-MS. Metode uji untuk menentukan aktivitas antibiotik dan kombinasinya dengan KKM digunakan metode difusi dan kontak gas.Hasil: Setelah dilakukan isolasi minyak atsiri kulit batang kayu manis, diperoleh jumlah rendemen sebesar 0,24% dengan lima komponen utama yang terkandung didalamnya, yaitu cinnamaldehyde (64,84%), 1,8-cineole (6,4%), dan benzyl benzoate (6,33%). Hasil uji aktivitas menunjukkan rata-rata diameter zona hambat ampisilin tunggal terhadap bakteri MRSA adalah sebesar 10,67 mm, sedangkan antibiotik ampisilin yang telah dikombinasi dengan minyak atsiri KKM sebesar 23,67 mm. Kesimpulan: Kenaikan aktivitas antibakteri ampisilin setelah dikombinasi dengan KKM adalah 121,84%. Hal ini menunjukkan bahwa penggunaan minyak atsiri KKM berpotensi sebagai terapi suportif bila digunakan bersama dengan ampisilin untuk mengatasi infeksi MRSA.Kata kunci: ampisilin, bakteri MRSA, minyak atsiri, kayu manis, kontak gas
AKTIVITAS ANTIBAKTERI SENYAWA ISOLAT DAUN MUNDU (Garcinia dulcis) TERHADAP BAKTERI PATOGEN GRAM POSITIF Hady Anshory Tamhid; Triana Hertiani; Subagus Wahyuono
Jurnal Ilmiah Farmasi Vol. 11 No. 2 (2015): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

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Abstract

Standardization of Specific and Non-Specific Parameters of Propolis Extract as Raw Material for Herbal Product Yandi Syukri; Ririk Purwati; Nadia Hazami; Hady Anshory Tahmid; Annisa Fitria
EKSAKTA: Journal of Sciences and Data Analysis VOLUME 1, ISSUE 1, February 2020
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/EKSAKTA.vol1.iss1.art6

Abstract

This study aims to standardize the specific and non-specific parameters of propolis extract originating from East Java, Indonesia, to fulfil the requirements as a herbal raw material. Standardization was carried out on propolis ethanol extract taken at three different harvesting times. Standardization was carried out on specific parameters including the content of dissolved compounds, chemical content of extracts and chromatogram patterns, while the non-specific parameters of the extract included water content, ash content residue, density, microbial contamination, and heavy metal contamination. Specific extract parameters showed that the water-soluble extract content was 2.1-3.5%; levels of ethanol-soluble extract 62.00-84.00%; total flavonoid levels of 0.015-0.072 mg ER / g; and total phenol content of 0.0039-0.0053 mg ER / g. Non-specific parameters indicate that the water content is 10.72-10.90%; drying losses 10.05-10.63%; total ash content of 0.08-0.65%, density of 0.88-0.89 g / mL; Pb levels from 6.55-9.01 mg / kg; Cd content of 0.50-1.22 mg / kg, Cu content of 0.82-1.13 mg / kg; the total plate number is 10 colonies / g and the yeast fungus number is 10 colonies / g. It can be concluded that propolis extract from the East Java region of Indonesia fulfills the requirements as a raw material for herbal products in Indonesia.
Hepatoprotective Effect of Corn Silk Infusion in Male Wistar Rats Arba Pramundita Ramadani; Hady Anshory Tamhid; Tika Luthfi Sadrina; Jasno Jasno; Mabrurotul Mustafidah
EKSAKTA: Journal of Sciences and Data Analysis VOLUME 1, ISSUE 1, February 2020
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/EKSAKTA.vol1.iss1.art8

Abstract

The use of medicinal plants in treating various disease has been reported since long time ago, including for hepatic disease. Corn silk contains phytochemicals of medical benefit such as flavonoids compounds which act as antioxidant agents and has been widely reported possess hepatoprotective effect. Using a model of carbon tetrachloride (CCl4)-induced hepatotoxicity in 36 male Wistar rats, this study investigated the effect of corn silk infusion and assessed using enzymes produced by the liver in plasma [alkaline phosphatase (ALP) and liver glutathione (GSH)]. The corn silk infusion (in 50, 100, and 200 mg/kg BW doses) were administered 24 hours after CCl4-induction liver damage with 3ml/kg BW CCl4 in olive oil (1:1, v/v), intraperitoneally for seven days. Along with corn silk groups, distilled water (0.2 mL/kg BW) and Curcumin (100 mg/kg BW) were given for induction and drug control, respectively. In the end of the study (8th day), the level of both ALP dan GSH were measured. The differences among groups for GSH and ALP level were statistically calculated using ANOVA method.  The result showed that the corn silk infusion is active at 200 mg/kg BW based on both ALP (18.74% decreased) and GSH (5-7% increased) level. Moreover, the flavonoid compound was detected on the infusion that may contribute on its hepatoprotective activity. In conclusion, corn silk infusion owned hepatoprotective effect in male Wistar rats.
PENDAMPINGAN PEMBUATAN MINUMAN KESEHATAN BERBASIS TANAMAN OBAT INDONESIA BAGI PENYANDANG DISABILITAS DI SLB YAPENAS YOGYAKARTA Yosi Febrianti; Hady Anshory T; Yulianto .; Novyan Lusiyana
Jurnal Education and Development Vol 9 No 4 (2021): Vol.9 No.4 2021
Publisher : Institut Pendidikan Tapanuli Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (426.117 KB) | DOI: 10.37081/ed.v9i4.2956

Abstract

Persons with disabilities are members of society who are still economically difficult to empower. Based on the results of a need assessment with one of the teachers at SLB YAPENAS, finding the fact that currently in the field of education for persons with disabilities there is no entrepreneurial curriculum available, of course, this is important because persons with disabilities have the potential to be economically independent. The lack of skills and a negative stigma against the abilities of persons with disabilities. This community service program aims to improve and empower the economy and encourage mentally retarded persons to become economically independent business actors. This activity is carried out in several stages, namely facilitating the availability of materials and equipment needed for the production process of health drinks, counseling on Indonesian medicinal plants, providing training in making health drinks from medicinal plants, providing training in making health drinks from medicinal plants and training in product packaging and marketing techniques. This assistance activity resulted in a pilot business for people with disabilities in the form of a health drink based on Indonesian medicinal plants. Business development needs to be done by diversifying commodities to increase and develop the marketing of health drink products.
Standardization of leaf extract of red betel(Piper crocatum) leaves using ethanol Heni Sundari; M. Hatta Prabowo; Farida Juliantina Rachmawaty; Hady Anshory Tamhid
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 7, No 1, (2015)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol7.Iss1.art2

Abstract

Background: Red betel vine (Piper crocatum Ruiz & Pav) is known empirically to have properties to cure various kinds of diseases. It contains flavonoids, alkaloids, polifenolat compounds, tannins and essential oil compounds. Standardization in the pharmacy is required to ensure the level of quality, fulfill the standard requirement of chemical, biological, and pharmaceutical, including the guarantee of stability as pharmaceutical products generally.Objective: To investigate the standard specific and non-specific parameters set by Food and Drug Supervisory Agency (FDSA) of ethanol leaf extract of red betel leaves.Methods: The study began with sample preparation, then extracted by maceration method to get the active compounds in the lumpy extract. Extract was analyzed with standard specific and non-specific parameters set by FDSA. Results were analyzed with descriptive analysis method.Results: The features of leaf extract of red betel vine leaves using are organolepticly viscous, dark green,and has a distinctive odor with a bitter spicy taste. The yield, water content, ash content, and specific gravity of extract were 14.8%, 0.353%, 0.16%, 0.729 respectively. Total mold contamination of extract satisfied the standard criteria that was below the limit of a maximum of 10 colonies/gram. Metal contamination of lead (Pb) was 1. 404 mg/kg and Cadmium (Cd) was 0. 223 mg/kg. Chromatographic profile of the Gas Chromatography-Mass Spectrometry (GC-MS) red betel vine leaves ethanol extract contains compounds caryophyllene, germacrene-D and some other compounds with low similiaritas index, and has a marker compound which is suspected possibly trimethoxyallyl benzen.Conclusion : The ethanol extract of red betel vine (Piper crocatum Ruiz & Pav) leaves is an extract of the organolepticly viscous, dark green color, distinctive smell, bitter taste, and spicy. The ethanol extract of red betel vine leaves satisfies the standard level set by FDSA and has the marker compound which is expected likely Trimethoxyallyl benzen.
Chemical compounds and antibacterial activity of Garcinia dulcis (Roxb)kurz. Hady Anshory Tamhid
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 10, No 1, (2019)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol10.Iss1.art11

Abstract

Garcinia dulcis is a medicinal plant used traditionally to treat various diseases including infections of wounds and ulcers. The antibacterial activity of this plant has also been widely reported, but the most potent compounds as an antibacterial agent are not widely reported, even though the compounds contained in this plant is well known. This paper reviews the compounds contained in G. dulcis plants and their potential as antibacterial agents. Each part of this plant, such as leaves, fruits, flowers, seeds, stems, and roots, contains secondary metabolites which are potential antibacterial agents. Here are described the compounds contained in each part of the plant, such as xanthones, the most dominant compounds, then flavonoids, benzophenones, chromones, and triterpenoid. Their antibacterial activity is also described, especially those that have strong activity against bacteria. The molecular structure and the possibilities of how the antibacterial mechanism are also discussed.  Eleven compounds that have the potential to be used as antibacterial agents for the treatment of infectious diseases. Garcigerin A (27) and a-mangostin (54) are compounds that have the most vigorous activity against S. aureus and MRSA compared to the other compounds. The Compounds that have strong activity can be used as antibacterial agents for anti-infective therapy, although they must go through various further studies.
Variasi Dosis Spray Ekstrak Etanol Solanum melongena L. dan Cananga adorata terhadap Perubahan Gejala Toksik, Fungsi Hepar, dan Hispatologi Mencit (Mus musculus) Zainal Fikri; Yunan Jiwintarum; Maruni Wiwin Diarti; Hady Anshory Tamhid
Jurnal Kesehatan Manarang Vol 8 No 2 (2022): Agustus 2022
Publisher : Politeknik Kesehatan Kemenkes Mamuju

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33490/jkm.v8i2.656

Abstract

The purpose of this study was to determine toxic symptoms (loss of reflex), enzyme activity of SGOT and SGPT, and liver histopathology of experimental mice (Mus musculus) exposed to a combination formulation of 96% ethanol extract spray of Solanum melongena L. and Cananga adorata flower oil. True experimental research design with Post Test Only Control Group Design, this study used 4 treatment groups and 1 control group, data collected in the form of toxic symptoms (loss of reflex), SGOT enzymatic activity, and liver histopathological picture of experimental mice (Mus musculus). Which was analyzed by One Way Anova and Descriptive test. The results showed that the changes in toxic physical symptoms (loss of reflexes) of experimental mice (Mus musculus) after 30 minutes of spraying were strange reactions to walking around without direction, sensitivity to touch, changes in social interaction colliding with each other, lethargy, eye opacity and excessive blinking, respiratory rate. increased, which returned to normal at 4 hours to 168 hours after spraying. The activity of the SGOT and SGPT enzymes after 168 hours of spraying showed that the higher the dosage of the formulation, the higher the activity of the SGOT and SGPT enzymes, but the increase was still within normal limits, the histopathological results of liver morphology grading at various research doses showed Normal and Mild. Conclusion: Solanum melongena L. and Cananga adorata flower oil combined did not cause pathological effects in experimental mice (Mus musculus).
Aktivitas antioksidan ekstrak etanol daun Sonchus arvensis L. Rochmy Istikharah; Khittah Dea Annisa Annisa; Nofran Putra Pratama; Hady Anshory  Tamhid
Jurnal Ilmiah Farmasi Vol. 11 No. 2 (2015): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Intisari Penelitian terhadap ekstrak air dan ekstrak metanol daun Sonchus arvensis L. atau tempuyung telah terbukti mempunyai khasiat sebagai antioksidan. Salah satunya diduga karena kandungan flavonoidnya. Etanol merupakan pelarut yang paling sering digunakan dalam proses ekstraksi dan mempunyai kemampuan yang baik dalam mengekstraksi flavonoid. Penelitian ini bertujuan untuk mengetahui aktivitas ekstrak etanol daun S. arvensis sebagai antioksidan dengan metode DPPH (1,1-diphenyl-2-picrylhydrazyl) dan metode ABTS (2,2’-azino-bis-3-ethylbenzothiazoline-6-sulphonic acid). Ekstrak daun S. arvensis diperoleh melalui proses maserasi dengan etanol 70%. Uji aktivitas antioksidan dilakukan dengan menggunakan DPPH dan ABTS sebagai sumber radikal bebas terhadap seri kadar ekstrak sehingga dapat dihitung nilai IC50 melalui perhitungan PROBIT. Seri kadar vitamin C digunakan sebagai kontrol positif. Hasil uji peredaman radikal bebas menunjukkan nilai IC50 S. arvensis sebesar 138,26 µg/mL terhadap ABTS dan 64,97 µg/mL terhadap DPPH. Ekstrak etanol daun S. arvensis yang diuji mempunyai aktivitas antioksidan. Kata kunci : Sonchus arvensis, antioksidan, ABTS, DPPH
Co-Authors Aditya Fadilah Amalia, Senya Putri Anjayani, Nuri Annisa Fitria Arba Pramundita Ramadani Arde Toga Nugraha Asih Triastuti Farida Juliantina Rachmawaty Fitri Apriliany, Fitri Heni Sundari Holyness Nurdin Singadimedja Jasno Jasno Khittah Dea Annisa Annisa LINDA SUKMARINI Lutfi Chabib, Lutfi M. Hatta Prabowo Maruni Wiwin Diarti Mustafidah, Mabrurotul Nadia Hazami Novyan Lusiyana Nugroho, Ardi Pramundita, Arba Prasasti, Syita Shevia Pratama, Nofran Putra Primahana, Gian Putra, Prima Aulia Retno Murwanti Ririk Purwati Rochmy Istikharah Subagus Wahyuono Tika Luthfi Sadrina Triana Hertiani Yandi Syukri Yosi Bayu Murti Yulianto . Yunan Jiwintarum Zainal Fikri