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All Journal ISM (Intisari Sains Medis) : Jurnal Kedokteran JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Judie Hartono
Andrology Department, Doctor Soetomo General Hospital, Surabaya, Indonesia Biomedicine Department, Medical Faculty Of Airlangga University, Surabaya, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Administration of sildenafil citrate not able to reduced hs-CRP on erectile dysfunction patient at Doctor Soetomo Hospital, Surabaya, Indonesia I Gusti Ngurah Pramesemara; Rossy Sintya Marthasari; Rezia Octarina; Ahmad Ricardo Syukur Silalahi; Judie Hartono; Tjahjo Djojo Tanojo
Intisari Sains Medis Vol. 10 No. 2 (2019): (Available online: 1 August 2019)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (362.292 KB) | DOI: 10.15562/ism.v10i2.410

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Background: Phosphodiesterase type-5 (PDE5) inhibitors was the first choice for the oral treatment of erectile dysfunction because of its ability to prevent endothelial dysfunction and restored erectile function properly. However, the inflammatory parameter such as hs-CRP can be used to assess the performance of PDE5 inhibitors as well as clinical questionnaires, IIEF-5, and EHS. So that, this study aims to determine the effect of PDE5 inhibitors administration such as sildenafil citrate 50 mg per day can decrease the value of hs-CRP, as well as increased the IIEF-5 and EHS at Dr. Soetomo General Hospital.Methods: A true clinical experimental studies used pretest and posttest control group design were carried out among 20 patients during 4 weeks. In the next 2 weeks, the crossover was conducted among respondents for the washout period whereas divided into 2 groups, control (K1 and K2) and treatment (P1 and P2). Data were analyzed using Statistical Package for the Social Sciences (SPSS) version 16.0 software for Windows.Results: The average age of group K1 and P2 was 51 ± 12.07 years old whereas 48.60 ± 15.40 years old in group P1 and K2. The research was conducted in Andrology Clinic of Doctor Soetomo Hospital in Surabaya during June to November 2017. The research data were not normally distributed, then analyzed by two-tail T-group tests and Wilcoxon test at significance level α=0.05. The results showed that PDE5 inhibitors did not decrease the hs-CRP significantly (p>0.05), but increased EHS (p<0.05) and increased IIEF-5 (p<0.05) significantly.Conclusion: This study concluded that the administration of sildenafil citrate per day by oral increased the EHS and IIEF-5, but not able to reduced hs-CRP in patients with erectile dysfunction significantly.
Remaja pria 18 tahun dengan hipogonadotropik-hipogonadisme dan postur tubuh pendek: sebuah laporan kasus Metanolia Sukmawati; Antonius Wahyudi; Judie Hartono; Tjahjo Djojo Tanojo
Intisari Sains Medis Vol. 10 No. 3 (2019): (Available online: 1 December 2019)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (912.214 KB) | DOI: 10.15562/ism.v10i3.465

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Background: Hypogonadotropic hypogonadism (HH) is congenital or acquired disease affects hypothalamus or pituitary, so the secretion of GnRH, FSH, LH, and testosterone are inadequate. Clinical manifestations both physical and psychological impair patient’s quality of life, so authors try to report this case.Case description: An 18 years old man complained about a small penis. Small penis cause patient had introvert personality and problems in social relations. On anthropometric status, body weight was below 3rd percentile, height was below 3rd percentile, and body mass index (BMI) was thin. The genital examination was 2nd-grade tanner, penis with 3 cm length and 3 cm circumference, minimal little pubic hair, and testicular volume <2 cc. Ultrasound examination showed no presence of testes in the right or left scrotum fossa, inguinal, and lumbar region. Chromosome analysis showed 46 XY, and hormones analysis found FSH, LH, and testosterone below the normal limit. The patient was given 2000 unit HCG injection and after that FSH, LH, and testosterone hormone increase compared before HCG injections.Conclusion: HH can impair physical and psychological patient’s quality of life through delays in sexual maturation and bone maturation. Strategies to recognize symptoms in early childhood and puberty induction on time can significantly improve the sexual and reproductive function of HH patients.
PERBEDAAN PROFIL ANALISIS SEMEN PADA PRIA DI POLI ANDROLOGI RUMAH SAKIT UMUM DAERAH DR. SOETOMO BERDASARKAN KRITERIA INDEKS MASSA TUBUH Williana Suwirman; Zakiyatul Faizah; Relly yanuari Primariawan; Judie Hartono; R Haryanto Aswin
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 6 No 1 (2018): JIMKI : Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 6.1 Edisi April - Sep
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

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Latar belakang : Hubungan antara indeks massa tubuh dengan kualitas semen masih kontroversial. Tujuan penelitian ini adalah menilai hubungan antara indeks massa tubuh dengan kualitas sperma di RSUD Dr. Soetomo, Surabaya, Indonesia. Metode : Penelitian ini adalah penelitian observasional yang menggunakan desain penelitian retrospektif-cross sectional. Sampel penelitian yang digunakan adalah 502 pria yang dibagi kedalam 4 kelompok berdasarkan indeks massa tubuhnya, yaitu kurus (<18.5), normal (18.5-25), kelebihan berat badan (25.1-27), and obesitas (>27). Data dianalisis menggunakan Fisher’s exact test. Hasil : Tidak ada perbedaan signifikan di antara tiap kelompok berdasarkan seluruh parameter analisis semen yang meliputi konsentrasi, motilitas, dan morfologi sperma. Kesimpulan : Tidak ada perbedaan profil analisis semen yang signifikan di antara setiap kelompok indeks massa tubuh.
Co-Authors Ahmad Ricardo Syukur Silalahi Antonius Wahyudi Aswin, R. Haryanto Faizah, Zakiyatul I Gusti Ngurah Pramesemara Metanolia Sukmawati Relly Yanuari Primariawan, Relly Yanuari Rezia Octarina Rossy Sintya Marthasari Tanojo, Tjahjo Djojo Williana Suwirman