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PENGGUNAAN SITOLOGI IMPRINT BERSAMAAN DENGAN PEMERIKSAAN FROZEN SECTION PADA KARSINOMA PAYUDARA INVASIF Nana Liana; Aswiyanti Asri; Meta Zulyati Octora
JURNAL KEDOKTERAN DAN KESEHATAN Vol 10, No 1 (2023)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/JKK.V10I1.19847

Karsinoma payudara invasif adalah keganasan terbanyak di dunia maupun di Indonesia. Karsinoma payudara invasif merupakan keganasan yang berasal dari sel epitel kelenjar payudara. Pada kasus dugaan keganasan dibutuhkan tambahan modalitas selain mammografi. Salah satunya dengan frozen section intraoperatif. Tindakan frozen section berguna mengkonfirmasi diagnosis keganasan dan penentuan tatalaksana selanjutnya. Kesalahan interprestasi sediaan frozen section bisa terjadi karena adanya artefak sehingga menghalangi patolog melihat perubahan arsitektur dan detail morfologi sel tumor. Oleh karena itu dibutuhkan Prosedur tambahan untuk menilai morfologi sel seperti sitologi imprint. Telah dilaporkan kasus seorang perempuan usia 68 tahun dengan keluhan benjolan di payudara kiri. Benjolan tanpa disertai nyeri dan tidak ada nipple discharge. Benjolan berukuran 4 cmx3cmx2 cm, warna kulit tidak ada kelainan, ulkus tidak ada, kosistensi padat, agak terfiksir. Pasien didiagnosis sebagai tumor mammae sinistra suspek ganas. Pasien menjalani tindakan operasi mammae sinistra, dengan analisis frozen section intraoperatif bersamaan dengan sitologi imprint. Hasil pemeriksaan mikroskopik imprint sesuai dengan frozen section yaitu carcinoma mammae. Frozen section adalah prosedur yang bermanfaat untuk mengkonfirmasi diagnosis yang diduga ganas secara klinis. Penggunaan sitologi imprint bersamaan dengan frozen section dapat mengatasi kesulitan menilai morfologi sel sehingga meningkatkan akurasi diagnosis.

Edukasi Penyakit Faringitis Akut terhadap Masyarakat di Kecamatan Bungus Teluk Kabung Kota Padang Ruhsyahadati Ruhsyahadati; Febianne Eldrian; Nana Liana; Rahma Triyana; Prima Adelin; Wisda Widiastuti; Anandia Putriyuni
Jurnal Pengabdian Pada Masyarakat Vol 8 No 4 (2023): Jurnal Pengabdian Pada Masyarakat
Publisher : Universitas Mathla'ul Anwar Banten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30653/jppm.v8i4.466

Faringitis akut merupakan salah satu penyakit infeksi saluran pernafasan atas dengan kunjungan terbanyak di layanan kesehatan. Penyakit ini dapat menimbulkan komplikasi yang mengancam nyawa, terutama pada anak-anak. Dengan demikian diperlukan edukasi kepada masyarakat mengenai penyebab dan upaya pencegahan serta penatalaksanaan penyakit ini. Pengabdian masyarakat ini dilakukan di Kecamatan Bungus Teluk Kabung, Kota Padang, Sumatera Barat. Kegiatan diawali dengan pengisian kuesioner oleh responden. Selanjutnya kegiatan penyuluhan dilakukan dengan menyebarkan brosur dan memperlihatkan video singkat mengenai penyakit faringitis akut. Berdasarkan hasil pengisian kuesioner didapatkan hasil sebanyak 45,5% responden memiliki pengetahuan baik, namun masih ada 24,2% memiliki pengetahuan buruk. Pemberian edukasi ini diharapkan dapat meningkatkan pengetahuan masyarakat Kecamatan Bungus Teluk Kabung mengenai penyakit faringitis akut sehingga dapat menurunkan angka kesakitan infeksi saluran pernafasan atas. Acute pharyngitis is one of the most common upper respiratory tract diseases that require medical attention. Particularly in children, this condition can have life-threatening complications. As a result, it is critical to educate the public on the etiology of this disease in addition to strategies to prevent and manage it. This activity was done at the Bungus Teluk Kabung District of Padang City, West Sumatra. Respondents begin the activity by completing a questionnaire. Furthermore, education was conducted by distributing brochures and watching a short movie about acute pharyngitis. According to the results of the questionnaire, it was observed that 15 people (45.5%) had good knowledge and 8 people (24.2%) had poor knowledge. In order to decrease the morbidity rate of upper respiratory tract infections, education is intended to improve the knowledge of acute pharyngitis among the locals of the Bungus Teluk Kabung District.

The Role of Probiotics as An Adjuvant Therapy for Sepsis Against Multidrug-Resistant Bacteria Ruhsyahadati Ajisman; Rinita Amelia; Rahma Triyana; Roland Helmizar; Sri Nani Jelmila; Nana Liana; Dian Puspita; Letvi Mona
Biomedical Journal of Indonesia Vol. 9 No. 3 (2023): Vol 9, No 3, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v9i3.170

The role of probiotics on sepsis, particularly when induced by multidrug-resistant (MDR) bacteria, is mediated through complex biochemical pathways. Probiotics demonstrate a capacity to effectively combat infections and reduce mortality rates in sepsis cases. A significant contributor to this efficacy is attributed to the short-chain fatty acids (SCFAs) produced by these probiotics. SCFAs play a critical role in modulating the immune system, primarily by influencing the production of inflammatory cytokines, fortifying the integrity of intestinal epithelium, preventing cellular apoptosis, and maintaining the balance of gut microbiota. Moreover, probiotics are instrumental in counteracting the detrimental impacts of excessive antibiotic use, which is a major contributing factor to the emergence of MDR bacterial strains. The integration of probiotics with conventional therapeutic approaches offers a viable and potentially effective strategy in the management of sepsis caused by MDR bacteria, suggesting a promising direction for future clinical interventions.

PENGGUNAAN SITOLOGI IMPRINT BERSAMAAN DENGAN PEMERIKSAAN FROZEN SECTION PADA KARSINOMA PAYUDARA INVASIF Nana Liana; Aswiyanti Asri; Meta Zulyati Oktora
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 10 No. 1 (2023): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Univers
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v10i1.328

Karsinoma payudara invasif adalah keganasan terbanyak di dunia maupun di Indonesia. Karsinoma payudara invasif merupakan keganasan yang berasal dari sel epitel kelenjar payudara. Pada kasus dugaan keganasan dibutuhkan tambahan modalitas selain mammografi. Salah satunya dengan frozen section intraoperatif. Tindakan frozen section berguna mengkonfirmasi diagnosis keganasan dan penentuan tatalaksana selanjutnya. Kesalahan interprestasi sediaan frozen section bisa terjadi karena adanya artefak sehingga menghalangi patolog melihat perubahan arsitektur dan detail morfologi sel tumor. Oleh karena itu dibutuhkan Prosedur tambahan untuk menilai morfologi sel seperti sitologi imprint. Telah dilaporkan kasus seorang perempuan usia 68 tahun dengan keluhan benjolan di payudara kiri. Benjolan tanpa disertai nyeri dan tidak ada nipple discharge. Benjolan berukuran 4 cmx3cmx2 cm, warna kulit tidak ada kelainan, ulkus tidak ada, kosistensi padat, agak terfiksir. Pasien didiagnosis sebagai tumor mammae sinistra suspek ganas. Pasien menjalani tindakan operasi mammae sinistra, dengan analisis frozen section intraoperatif bersamaan dengan sitologi imprint. Hasil pemeriksaan mikroskopik imprint sesuai dengan frozen section yaitu carcinoma mammae. Frozen section adalah prosedur yang bermanfaat untuk mengkonfirmasi diagnosis yang diduga ganas secara klinis. Penggunaan sitologi imprint bersamaan dengan frozen section dapat mengatasi kesulitan menilai morfologi sel sehingga meningkatkan akurasi diagnosis.

Edukasi Penyakit Mastitis Saat Menyusui di Kantor Lurah Gantiang, Padang Panjang Timur Nana Liana; Meta Zuliyati Oktora; Sri Nani Jelmila; Budi Yulhasfi Febrianto; Dita Hasni
Jurnal Abdimas Kesehatan (JAK) Vol 4, No 3 (2022): November
Publisher : Sekolah Tinggi Ilmu Kesehatan Baiturrahim Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36565/jak.v4i3.379

Breastfeeding or in a foreign language called breasting is the feeding of breast milk (breast milk) as a natural food provided to the baby. The breastfeeding process can be hampered due to several problems, one of which is mastitis. Mastitis in nursing mothers is an infection of breast tissue when the mother is breastfeeding, mainly occurs due to blockage of breast milk ducts by a coagulated breast milk and accompanied by bacteria that enter the breast tissue through the nipple. The incidence of mastitis is estimated to occur in the first 12 weeks to the second year of feeding. Mastitis needs to be considered because being one of the reasons for the mother to stop breastfeeding can proceed to other diseases such as breast abscesses. Lack of knowledge about mastitis and its treatment causes many mothers to detect mastitis too late and aggravate the state of mastitis. Therefore, prevention and education related to mastitis when the mother is breastfeeding is needed.This activity was held on July 29, 2022 for 3 hours and was attended by 23 mothers of reproductive age who lived in Gantiang village, Padang Panjang Timur. The results of this activity obtained differences in the average level of knowledge of participants before and after counseling. This activity has an impact on increasing public knowledge related to mastitis so that it can increase the success of breastfeeding and prevent stunting.

Subtipe Histopatologis Adenokarsinoma Kolorektal Berdasarkan WHO : Implikasi Terhadap Prognosis Nana Liana; Yessy Setiawati; Ruhsyahadati; Rahma Triyana; Roland Helmizar
Scientific Journal Vol. 4 No. 3 (2025): SCIENA Volume IV No 3, May 2025
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v4i3.209

Adenokarsinoma kolorektal merupakan tipe histologis paling umum dari kanker kolorektal yang menunjukkan heterogenitas morfologis dan biologis yang tinggi. Variasi ini memengaruhi tidak hanya pola penyebaran dan respons terhadap terapi, tetapi juga prognosis pasien secara keseluruhan. Klasifikasi histopatologi yang ditetapkan oleh World Health Organization (WHO) memberikan pedoman sistematis dalam membedakan berbagai subtipe adenokarsinoma kolorektal, seperti adenokarsinoma konvensional, mucinous, signet-ring cell, dan medullary carcinoma. Subtipe-subtipe ini diketahui memiliki perbedaan signifikan dalam perilaku klinis dan sensitivitas terhadap pengobatan. Oleh karena itu, pemahaman dan penerapan klasifikasi WHO sangat penting untuk meningkatkan akurasi diagnosis, perencanaan terapi yang tepat sasaran, serta prediksi prognosis yang lebih akurat. Tujuan penulisan ini adalah untuk menyoroti pentingnya klasifikasi histopatologi WHO dalam menunjang pengambilan keputusan klinis terkait terapi dan prognosis pasien dengan adenokarsinoma kolorektal.

Deteksi Dini Kanker Serviks dan Edukasi Kegunaan Pemeriksaan Pap Smear Nana Liana; Nurwiyeni; Meta Zulyati Oktora; Anandia Putriyuni
AMMA : Jurnal Pengabdian Masyarakat Vol. 2 No. 4 (2023): AMMA : Jurnal Pengabdian Masyarakat
Publisher : CV. Multi Kreasi Media

Show Abstract | Download Original | Original Source | Check in Google Scholar

Cervical cancer is the second largest malignancy after breast cancer in Indonesia. The incidence is increasing every year. In the United States and several other countries, the incidence of cervical cancer has decreased due to public health services and lifestyle changes as well as early implementation through pap smears. In developing countries, the mortality and incidence of cervical cancer has also decreased by 34-80% in the last 50 years. This is sufficient because the period of occurrence of cervical cancer is long and 90-95% of pathological changes in the epithelium can be determined through the Pap smear test. However, in developing countries, health services are still limited and there are no screening programs, cervical cancer is still the leading cause of death in women. Cervical cancer is often diagnosed at an advanced stage and the survival rate is low. On the other hand, the cure rate for early cervical cancer is very high. Therefore, it is important for women to undergo regular pap smears test so that the health condition of the cervix can be monitored and cervical cancer can be detected early.

GAMBARAN KLINIKOPATOLOGI KARSINOMA PAYUDARA DI RSUP DR. M. DJAMIL PADANG TAHUN 2023 Muhammad Rifki; Nana Liana; Irwan Triansyah; Roland Helmizar; Lismawati Lismawati; Desi Aliefia; Muhammad Rizki Saputra; Ruhsyahadati Ruhsyahadati; Rahma Triyana
Nusantara Hasana Journal Vol. 5 No. 12 (2026): Nusantara Hasana Journal, May 2026
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i12.2046

Background: Breast cancer is a malignancy originating from epithelial cells of the breast ducts or lobules. Clinicopathological characteristics are important in determining prognosis and treatment. Understanding these features is essential to support early detection and improve management strategies. Objective: This study aimed to describe the clinicopathological features of breast cancer patients at RSUP Dr. M. Djamil Padang in 2023. Methods: This descriptive observational study used a cross-sectional design with secondary data. A total of 114 samples were collected using the total sampling technique. Data were analyzed using univariate analysis with Statistical Product and Service Solution (SPSS) version 25. Results: Among 114 breast cancer patients, the most common age group was 35–44 years, accounting for 37 patients (32.5%). The predominant histopathological subtype was Mixed Infiltrating Duct NST with Lobular Carcinoma in 37 patients (32.5%). Histopathological grading was most commonly grade 2 in 79 patients (69.3%). Positive lymphovascular invasion was identified in 76 patients (66.7%). The most frequent molecular subtype was Luminal B, found in 51 patients (44.7%). Conclusion: Breast cancer was most prevalent in patients aged 35–44 years. The dominant histopathological subtype was Mixed Infiltrating Duct NST with Lobular Carcinoma, with grade 2 and positive lymphovascular invasion most frequently observed. Luminal B was the predominant molecular subtype. Increasing awareness of early detection through breast self-examination is recommended.

EDUKASI 10 PESAN GIZI SEIMBANG SEBAGAI UPAYA PENINGKATAN PENGETAHUAN MASYARAKAT DI PUSKESMAS KOTO PANJANG IKUA KOTO KOTA PADANG Muhammad Rizki Saputra; Bun Yurizali; Rahma Triyana; Ruhsyahadati Ruhsyahadati; Nana Liana; Rifkind Malik; Roland Helmizar; Suharni Suharni; Sri Wahyuni; Alif Dhuha
Nusantara Hasana Journal Vol. 6 No. 1 (2026): Nusantara Hasana Journal, June 2026
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v6i1.2177

Nutritional problems remain one of the major public health challenges in Indonesia. Limited public knowledge regarding healthy eating patterns can increase the risk of various health problems among both children and adults. This community service activity aimed to improve community knowledge regarding the 10 Messages of Balanced Nutrition through health education. The activity was conducted at Koto Panjang Ikua Koto Primary Health Center, Padang City, involving 45 participants consisting of fathers, mothers, and children. The methods used included educational presentations and interactive question-and-answer sessions. The results showed that participants were highly enthusiastic throughout the activity. The high level of participation during discussions indicated increased interest and awareness of the importance of implementing balanced nutrition principles. This educational intervention successfully enhanced participants’ understanding of diverse food consumption, physical activity, clean and healthy living behaviors, and regular nutritional status monitoring. This community service activity is expected to contribute to improving healthy lifestyle behaviors and the overall health quality of the community.

Hubungan Aktivitas Fisik dan Profil Lipid dengan Kategori Risiko Penyakit Kardiovaskular Aterosklerotik Berdasarkan ASCVD Risk Score Bun Yurizali; Nurmaines Adhyka; Muhammad Reyhan Febrian; Nana Liana
Scientific Journal Vol. 5 No. 3 (2026): SCIENA Volume V No 3, May 2026
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v5i3.362

Latar Belakang: Penyakit kardiovaskular aterosklerotik (Atherosclerotic Cardiovascular Disease/ASCVD) merupakan penyebab utama morbiditas dan mortalitas di dunia. Aktivitas fisik dan profil lipid merupakan faktor risiko yang dapat dimodifikasi, namun bukti mengenai hubungannya dengan kategori risiko ASCVD pada pasien rawat jalan di Indonesia masih terbatas.Tujuan: Penelitian ini bertujuan untuk menganalisis hubungan aktivitas fisik dan profil lipid (HDL dan LDL) dengan kategori risiko penyakit kardiovaskular aterosklerotik berdasarkan ASCVD Risk Score pada pasien rawat jalan. Metode: Penelitian ini menggunakan desain kuantitatif dengan pendekatan cross-sectional. Penelitian dilakukan pada 70 pasien rawat jalan yang memenuhi kriteria inklusi. Aktivitas fisik diukur menggunakan International Physical Activity Questionnaire (IPAQ), sedangkan kadar HDL dan LDL diperoleh dari hasil pemeriksaan laboratorium. Risiko penyakit kardiovaskular dinilai menggunakan ASCVD Risk Score dan dikategorikan menjadi risiko rendah, borderline, sedang, dan tinggi. Analisis bivariat menggunakan uji Spearman Rank, sedangkan analisis multivariat menggunakan regresi logistik ordinal dengan tingkat kemaknaan 95% (α = 0,05). Hasil: Analisis bivariat menunjukkan bahwa aktivitas fisik berhubungan negatif secara bermakna dengan kategori risiko ASCVD (r = –0,465; p < 0,001), demikian pula kadar HDL (r = –0,317; p = 0,007). Sebaliknya, kadar LDL tidak menunjukkan hubungan yang bermakna dengan kategori risiko ASCVD (r = 0,143; p = 0,236). Hasil analisis regresi logistik ordinal menunjukkan bahwa aktivitas fisik dan kadar HDL tetap berhubungan secara signifikan terhadap kategori risiko ASCVD, sedangkan kadar LDL tidak menunjukkan hubungan yang bermakna. Kesimpulan: Aktivitas fisik dan kadar HDL merupakan faktor yang berhubungan dengan kategori risiko penyakit kardiovaskular aterosklerotik berdasarkan ASCVD Risk Score pada pasien rawat jalan. Peningkatan aktivitas fisik dan optimalisasi kadar HDL perlu menjadi bagian dari strategi pencegahan primer penyakit kardiovaskular di fasilitas pelayanan kesehatan.

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