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Samsuar Samsuar
Program Studi Farmasi Universitas Tulang Bawang
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Public Health

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UJI DAYA HAMBAT ANTIBAKTERI KOMBINASI EKSTRAK DAUN PEPAYA ( Carica papaya L. ) DENGAN DAUN SIRIH ( Piper betle L. ) TERHADAP BAKTERI Staphylococcus aureus Amy Siska Zulyani; Samsuar Samsuar; Yuli Wahyu Tri Mulyani; Muti Dianda Sari
JFL : Jurnal Farmasi Lampung Vol. 11 No. 1 (2022): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v11i1.714

Abstract

Infection is a disease that is often found in Indonesia. Infectious diseases can be caused by one of the gram-positive bacteria, staphylococcus aureus bacteria. How to prevent infectious diseases is to inhibit the growth of Staphylococcus aureus bacteria. Papaya leaf plant (Carica papaya L.) and betel leaf plant (Piper betle L.) is a plant that has long been used by the community as a traditional medicine that can cure diseases, one of which is as an antibacterial. This study aims to find out the antibacterial bland power of the combination of papaya leaf extract with betel leaves in inhibiting Staphylococcus aureus bacteria. The method used is an experimental method of combining the concentration of papaya leaf extract with betel leaves, namely K1 (100%+0%), K2 (30%+70%), K3 (40%+60%), K4 (50%+50%), K5 (60%+40%), K6 (70%+30%), K7 (0%+100%), K (-) Aquadest, K(+) Chloramfenikol, which then concentrates on testing Staphylococcus aureus bacteria with the welling method. The variables measured in this study are the diameter of the bland zone. The observations were analyzed using one away anova with a sig (0.00) < A value (0.05) continued with Tukey that showed all treatments were different. This study can be concluded that the combination of papaya leaf extract with betel leaf proved to have a bland force of antibacterial activity against Staphylococcus aureus bacteria with the largest bland zone in K2 (papaya leaf extract 30% + 70% betel leaf extract) with an average diameter of 12.17 mm. Keywords: papaya leaves, betel leaves, infections, Staphylococcus aureus, bland zone.
AKTIVITAS ANTIBAKTERI KOMBINASI EKSTRAK DAUN JAMBU BIJI (Psidium guajava L.)DENGAN DAUN SIRSAK ( Annona muricata L.) TERHADAP Escherichia coli Samsuar Samsuar; Yuli Wahyu Tri Mulyani; Brigitta Saniscara R.H
JFL : Jurnal Farmasi Lampung Vol. 11 No. 2 (2022): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v11i2.806

Abstract

Infection is a type of disease that is often found in developing countries, including Indonesia. Escherichia coli is one of the most common causes of infection in society. The most common clinical symptoms in cases of this infection include watery diarrhea, abdominal cramps, low-grade fever, nausea, and malaise. Guava plants (Psidium guajava L.) and soursop plants (Annona muricata L.) are medicinal plants that are easy to find in Indonesia. Guava leaves and soursop leaves can be used as antibacterials. This study aims to determine the antibacterial activity of a combination of guava leaf extract (Psidium guajava L.) and soursop leaves (Annona muricata L.) against Escherichia coli bacteria. The method used is an experimental method of combining the concentrations of guava leaf extract and soursop leaves, namely K1 (100% + 0%), K2 (80% + 20%), K3 (60% + 40%), K4 (50% + 50% ), K5 (40%+60%), K6 (20%+80%), K7 (0%+100%), K(-) aquadest, K(+) Ciprofloxacin which was then followed by testing for Escherichia coli bacteria using the hole or well method. The variable measured in this study was the diameter of the inhibition zone formed in the combination of extracts. The results of observations were analyzed using One Way Annova with a sig value (0.000) <p value (0.050) followed by a follow-up tukey test which showed K1, K2, K3, K4, K5, K6, K7, K(-) and K(+) real different. It can be concluded from this study that the largest inhibition zone of combined extracts was found in K2 (80% guava leaf extract + 20% soursop leaf extract) with an average inhibition zone of 11.89 mm which belonged to the strong category. Inhibits the growth of E.coli bacteria. Keywords : guava leaves, soursop leaves, Escherichia coli, inhibition zone
UJI AKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL DAUN ANTING-ANTING (Acalypha australis L.) PADA MENCIT YANG DI INDUKSI KARAGENIN 1% Novita Sari; Samsuar Samsuar; Cindi Liyana
JFL : Jurnal Farmasi Lampung Vol. 11 No. 2 (2022): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v11i2.825

Abstract

Inflammation is the body's defense mechanism in response to tissue injury and disturbance by external factors. Anting-anting leaf (Acalypha australis L.) contain flavonoids and tannins suspected to have antiinflammatory activity.This study aims to examine the antiinflammatory activity of Anting-anting leaf (Acalypha australis L.) ethanol extract in mice induced by carrageenin 1%. Anti-inflammatory activity test was carried out using twenty-five (25) mice and each mice was induced using 1% carrageenin subplantarly. The mice were divided into 5 groups, group I as the negative control was administered 1% Na-CMC suspension, group II as the positive control was administered mefenamic acid 65 mg/kg BW, groups III, IV and V as the treatment group were administered 83, 166 and 332 mg/kg BW of Anting-anting leaf (Acalypha australis L.) ethanol extract. Inflammation volume was measured using a caliper every 60 minutes for 6 hours. Data were analyzed statistically using ANOVA (Analysis of variance). The results showed the Anting-anting leaf (Acalypha australis L.) ethanol extract 83, 166 and 332 mg/kg BW had anti-inflammatory activity, respectively (47.39 ± 1.7), (59.53 ± 0.9) and (50.56 ± 0.3)% in mice induced by carrageenin 1%. The ANOVA test showed there was a significant difference to the negative control. Based on the results of the study, it can be concluded that the ethanol extract from Anting-anting leaf (Acalypha australis L.) ethanol extract has anti-inflammatory activity with an effective dose of 332.28 mg/kg BW. Keywords: Anti-inflammatory, Anting-anting leaf, Acalypha australis L., carrageenin
AKTIVITAS ANTIBAKTERI KOMBINASI EKSTRAK DAUN KEMANGI (Ocymum x africanum L.) DENGAN DAUN PEPAYA (Carica papaya L.) TERHADAP Staphylococcus aureus Samsuar Samsuar; Yuli Wahyu Tri Mulyani; Ayu Mirda Sari
JFL : Jurnal Farmasi Lampung Vol. 12 No. 1 (2023): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v12i1.996

Abstract

Abstract Infectious diseases are one of the diseases that have suffered by many Indonesian people for a long time. S. aureus bacteria is the cause of pyogenic infections. Basil plants (Ocymum x africanum L.) and papaya plants (Carica papaya L.) can be used as antibacterial. This study aims to determine the antibacterial activity of the combination of basil and papaya leaf extracts against S. aureus bacteria. Using the Experimental Method with a combination of extract concentrations, namely K1 (0+100%), K2 (20%+80%), K3 (40%+60%), K4 (50%+50%), K5 (60%+40% ), K6 (80%+20%), K7 (100%+0%), K(-) aquadest, K(+) Oxfloxacin, followed by a test for S. aureus bacteria using the well method. The test results were analyzed using One Way Annova. with sig value (0.000) < p-value (0.05) followed by Tukey's further test which showed the combination of concentrations showed significant differences between the test groups. From this explanation, it can be concluded that the combination of basil leaf extract and papaya leaf extract can increase the inhibition zone, the largest inhibition zone is in K4 (50% basil leaf extract + 50% papaya leaf extract) the inhibitory response that appears 19.69 mm belongs to the strong category. inhibit the growth of S. aureus bacteria. Keywords: Antibacterial, basil leaf, papaya leaf, Staphylococcus aureus.
Co-Authors Amy Siska Zulyani Ayu Mirda Sari Brigitta Saniscara R.H Cindi Liyana Muti Dianda Sari Novita Sari Yuli Wahyu Tri Mulyani