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All Journal Indonesian Journal of Urology The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Laurentius Aswin Pramono
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Health Professions Medicine & Pharmacology Public Health

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Paradigm on Chronic Constipation: Pathophysiology, Diagnostic, and Recent Therapy Laurentius Aswin Pramono; Ahmad Fauzi; Ari Fahrial Syam; Dadang Makmun
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 13, NUMBER 3, Desember 2012
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (533.168 KB) | DOI: 10.24871/1332012174-180

Abstract

ABSTRACTChronic constipation is a medical gastrointestinal problem which can degrade patient’s quality of life. So far, the shifting pathophysiologic mechanism to colonic neuropathology has not been supported by diagnostic facility and therapy. Target therapy for chronic constipation related to enteric nervous system is still limited to study. Currently, the discovery of neurotrophin-3 has not shown any significant development needed in daily clinical practice. Until now study related to endoscopic full-thickness biopsy has not been done in human and waiting for its applications in daily practice. Targeted therapy for chronic constipation which is related to enteric nervous system is still limited to study. The discovery of neurotrophin-3, although currently on clinical trial phase II, still not showing any significant contribution in daily clinical practice. New pathophysiologic mechanism shifting the ‘idiopathic’ paradigm or ‘functional’ to colonic neuropathology has not been met with diagnostic modalities and therapy based on this knowledge. Study regarding endoscopic full-thickness biopsy to help revealing this novel mechanism has not been done in human. Henceforth, until now applied studies pertinent to this subject are longing in order for enteric neuron etiology can be firmly established Thus, in the future, translational study is demandingly needed for a firm establishment of diagnostic and therapeutic modalities to its currently evolving pathophysiology.  Keywords: chronic constipation, colon, enteric nervous system, neurotophin-3
RELATIONSHIP BETWEEN OVERWEIGHT AND OBESITY WITH LOWER URINARY TRACT SYMPTOMS (LUTS) DUE TO BENIGN PROSTATIC HYPERLASIA IN PRE-ELDERLY A PRELIMINARY STUDY Rusli, Bryant Agustino; Prihadi, Johannes Cansius; Rensa; Laurentius Aswin Pramono
Indonesian Journal of Urology Vol 30 No 3 (2023)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v30i3.778

Abstract

ABSTRACT Objective: The purpose of this study is to find the relation between overweight and obesity with lower urinary tract symptoms due to benign prostatic hyperplasia in pre-elderly. Material & Methods: This analytical study was conducted in a cross sectional manner to 113 respondents. LUTS assessment uses the International Prostate Symptoms Score questionnaire. Measurements for overweight and obesity, this study uses the BMI and waist circumference methods. Fisher's exact test with SPSS v.25 was used for data analysis. Results: Results from data analysis showed that there was no significant relationship between overweight and obesity based on the BMI method on LUTS, p = 0.122. The results also showed a significant relationship between central obesity and LUTS, p = 0.003. Conclusion: Central obesity can be identified as a risk factor for LUTS while overweight and obesity based on the BMI method cannot be considered as a risk factor. These results can be used as education for pre-elderly to reduce the risk of LUTS due to BPH. Keywords: Overweight, obesity, lower urinary tract symptoms, benign prostatic hyperplasia, pre-elderly.
Co-Authors Ahmad Fauzi Ari Fahrial Syam Dadang Makmun Prihadi, Johannes Cansius Rensa Rusli, Bryant Agustino