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All Journal Amerta Nutrition Gema Lingkungan Kesehatan
Brian Wasita
Department of Anatomical Pathology, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia
Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Red Rice Bran Extract Intervention Ability to Improve Lipid Profile and Malondialdehyde Levels in Type 2 Diabetes Mellitus Model Rats Isniati Dwijayanti; Brian Wasita; Ida Nurwati
Amerta Nutrition Vol. 6 No. 4 (2022): AMERTA NUTRITION
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v7i4.2022.404-413

Abstract

Background: Diabetes mellitus accompanied by oxidative stress can cause cardiovascular complications. Red rice bran extract contains antioxidants that have the potential to prevent oxidative stress and improve hyperlipidemia in patients with type 2 diabetes mellitus. Objectives: Analyzing the effect of red rice bran extract on lipid profile and malondialdehyde levels in a diabetes mellitus rat model. Methods: Pretest-Posttest Control Group Design. Thirty-five male Wistar Albino rats were divided into 5 groups, namely, negative control, positive control given acarbose as much as 1.8 mg/200gr/day, and 3 treatment groups given red rice bran extract, 165, 330, 660 mg/kg/day for 21 days, respectively. Results: There was a change in lipid profile and MDA levels (p<0.05) after the treatment of bran extract with doses of 165, 330, and 660 mg/kg BW/day. Red rice bran extract at a dose of 660 mg/kg BW/day can be an alternative to acarbose in reducing cholesterol, LDL, and MDA levels, as well as elevating HDL levels in type 2 diabetes mellitus rats. Conclusions: Red rice bran extract can significantly improve lipid profile and malondialdehyde levels in the type 2 diabetes mellitus rat model. Red rice bran extract at a dose of 660 mg/kg BW/day might be used as an alternative to acarbose in improving lipid profiles and MDA levels.
Pemberian Ekstrak Bunga Telang (Clitoria Ternatea L) Menurunkan Stres Oksidatif dan Meningkatkan Berat Badan pada Tikus Wistar Jantan Diabetes: Administrations of Butterfly Pea Flower (Clitoria Ternatea L) Extract Reduce Oxidative Stress and Increase Body Weight of Male Wistar Rats with Diabetes Tantri Febriana Putri; Brian Wasita; Dono Indarto
Amerta Nutrition Vol. 7 No. 3 (2023): AMERTA NUTRITION (Bilingual Edition)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v7i3.2023.400-405

Abstract

Background: Asian pigeonwings flower (Clitoria Ternatea L.) is a plant that contains high antioxidants. Numerous research studies have shown that CT flowers can reduce the blood glucose levels of diabetic rats. Lower blood glucose levels can reduce MDA in DM patients. Objectives: This study aimed to analyze the effect of CT on serum malondialdehyde (MDA) levels and body weight of diabetic rats. Methods: Male albino Wistar rats induced by streptozotocin 45 mg/kgBW and nicotinamide 110 mg/kgBW to generate type 2 diabetes. Diabetes rats were randomly divided into three groups:  T1 was the control of diabetic rats, T2 was given 300 mg/kgBW extract of CT, and T3 was given 600 mg/kgBW extract of CT for 21 days. Data collected before, during, and after treatment were analyzed using One Way ANOVA and LSD posthoc. Results: The mean of MDA in the T2 and T3 groups decreased on day 14 that was T2 4,67±0,17 µmol/l and T3 3,99±0,30 µmol/l, (p<0,001) and on day 21 also decreased that was T2 4,07±0,14 µmol/l and T3 3,34 ±0,23 µmol/l (p<0,001). While T1 did not experience a significant decrease. The mean of body weight in the T2 and T3 groups increased on day 14 that was T2 187,83±4,67 grams and T3 183,50±4,41 grams (p<0,001), and on day 21, also increased was T2 195,17±3,65 grams, 190,67±4,08 grams (<0,001). In contrast, T1 did not experience a significant increase. Conclusion: Administration of CT flower extract 300 mg/KgBW, and CT flower extract 600 mg/KgBW reduces serum MDA levels of diabetic rats compared to the control of diabetic rats.
The Hepatoprotective Role of Ethanolic Mangosteen Peel Extract (Garcinia mangostana L.) on MDA, TNF-α, E-Selectin, and SGPT Levels in Isoniazid-Induced Liver Fibrosis Wistar Rats Triyanta Yuli Pramana; Rodi Nur Fajri; Brian Wasita; Eti Poncorini Pamungkasari
Gema Lingkungan Kesehatan Vol. 24 No. 2 (2026): Gema Lingkungan Kesehatan
Publisher : Poltekkes Kemenkes Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36568/gelinkes.v24i2.525

Abstract

Isoniazid is a first-line anti-tuberculosis drug known to cause drug-induced liver injury (DILI) through oxidative stress and inflammatory mechanisms that contribute to the development of liver fibrosis. Mangosteen peel (Garcinia mangostana L.) contains xanthone compounds with antioxidant and anti-inflammatory properties, making it a potential hepatoprotective agent. This study aimed to determine the role of ethanol extract of mangosteen peel on malondialdehyde (MDA) levels, tumor necrosis factor-α (TNF-α) expression, E-selectin expression, and SGPT levels in the liver of isoniazid-induced fibrosis Wistar rats. This experimental study used a post-test only control group design. Twenty-eight male Wistar rats were randomly divided into four groups: negative control group, positive control group (isoniazid 50 mg/kgBW/day), treatment group 1 (isoniazid + mangosteen peel ethanol extract 250 mg/kgBW/day), and treatment group 2 (isoniazid + mangosteen peel ethanol extract 500 mg/kgBW/day) for 30 days. MDA and SGPT levels were measured using spectrophotometry, while TNF-α and E-selectin expression were assessed using immunohistochemistry. Administration of mangosteen peel ethanol extract significantly reduced MDA and SGPT levels and decreased TNF-α and E-selectin expression compared to the positive control group. The most significant reduction was observed in the group receiving the extract dose of 500 mg/kgBW. Mangosteen peel ethanol extract reduces MDA, TNF-α, E-selectin, and SGPT levels in isoniazid-induced Wistar rats. These findings demonstrate its hepatoprotective potential in a preclinical setting, further translational and clinical studies are warranted to evaluate its efficacy and safety in humans as potential hepatoprotective agent.
Co-Authors Dono Indarto Eti Poncorini Pamungkasari Ida Nurwati Isniati Dwijayanti Rodi Nur Fajri Tantri Febriana Putri Triyanta Yuli Pramana