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All Journal HAYATI Journal of Biosciences PROSIDING SEMINAR NASIONAL Majalah Kedokteran Bandung Health Science Journal of Indonesia Jurnal Keperawatan Soedirman (The Soedirman Journal of Nursing) Medical Journal of Indonesia Nexus Biomedika Nexus Kedokteran Translasional Jurnal Farmasi Klinik Indonesia Biomedika Jurnal Media Gizi Indonesia (MGI) Majalah Obat Tradisional Jurnal Gizi dan Kesehatan Smart Medical Journal Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) AcTion: Aceh Nutrition Journal Jurnal Gizi Klinik Indonesia SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Journal of Epidemiology and Public Health Indonesian Journal of Medicine Journal of Health Policy and Management Journal of Health Promotion and Behavior Journal of Maternal and Child Health Amerta Nutrition Jurnal Respirologi Indonesia Jurnal Aisyah : Jurnal Ilmu Kesehatan Indonesian Journal of Global Health research Jurnal Dunia Gizi Pena Medika : Jurnal Kesehatan Narra J Jurnal Pengabdian Masyarakat Sasambo Proceedings of the International Conference on Nursing and Health Sciences Jurnal Kesehatan Kusuma Husada Journal of Health and Nutrition Research Proceeding ISETH (International Summit on Science, Technology, and Humanity) Prosiding University Research Colloquium Journal Research Midwifery Politeknik Tegal Media Penelitian dan Pengembangan Kesehatan Jurnal Pembaruan Kesehatan Indonesia Penelitian Gizi dan Makanan (The Journal of Nutrition and Food Research) Jurnal Kesehatan Masyarakat
Dono Indarto
Universitas Sebelas Maret
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Antibacterial Test of Skin’s and Gastric Mucosa’s Extract from Frog Duttaphrynus melanostictus Against Methicillin-resistant Staphylococcus aureus (MRSA) Isolated from RSUD Dr. Moewardi Sejati, Nanda Eka Sri; ., Hudiyono; Indarto, Dono
Nexus Biomedika Vol 5, No 2 (2016): Nexus Biomedika
Publisher : Nexus Biomedika

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Abstract

Introduction : Methicillin-resistant Staphylococcus aureus (MRSA) is  now becoming global public health  problem. Meanwhile, new antibiotics development rate is limited. Duttaphrynus melanostictus’s skin secretion was known to have antibacterial effect against some gram negative and gram positive bacterias, but cannot inhibit MRSA. This study aimed to investigate whether there is any antibacterial effects from skin’s and gastric mucosa’s extract of Duttaphrynus melanostictus against MRSA isolated from RSUD Dr. Moewardi. Methods : Antibacterial effect was tested with disc diffusion method. The extracted specimens were dorsal skin, ventral skin, and gastric mucosa. Each groups were divided into three category : 25.00 % concentration of extract, 2.50 % concentration of extract, and 1.25 % concentration of extract. Extracts were tested against MRSA from RSUD Dr. Moewardi and Staphylococcus aureus ATCC 25923  as control. Clear zone diameter of each groups was compared with 10.00% , 1.00%, and 0.50% acetic acid and analyzed with nonparametric Mann Whitney test (α = 0.05). Results : Average of clear zone diameter from skin’s extract and gastric mucosa’s extract against MRSA from concentration 25.00%, 2.50%, 1.25%  was : ventral (35.83 ± 0.24 mm; 12.00 ± 0.16 mm; 7.08 ± 0.10 mm), dorsal (19.00 ± 0.41 mm; 7.40 ± 0.11 mm; 7.20 ± 0.04 mm),and  gastric mucosa (19.01 ± 0.41 mm; 6.08 ± 0.10 mm; 6.90 ± 0.07mm). Mann Whitney test of antibacterial effect between extract and acetic acid showed ventral skin’s extract from all groups was significantly different with p = 0.020 (25.00 % ventral skin’s extract  compared with 10.00 % acetic acid), p = 0.020 (2.50 % ventral skin’s extract compared with 1.00% acetic acid) and p = 0.019 (1.25% ventral skin’s extract compared with 0.50% acetic acid). Meanwhile, dorsal’s skin extract was significantly different in concentration 2.50% (p = 0.021) and 1.25% (p = 0.019). Gastric mucosa’s extract was significantly different in concentration 1.25% (p= 0.019). No difference of antibacterial effect from extract against both MRSA and MSSA (p = 0.974). Conclusion: Ventral skin extract from Duttaphrynus melanostictus had the most excellent antibacterial effects and was able to inhibit the growth of MRSA. Keyword : AMP, Duttaphrynnus melanostictus, MRSA, Ventral Skin 
Exposure of hazardous compounds in Furniture Painting Induces Oxidative Stress through Increasing Plasma Malondialdehyde (MDA) Levels Oktaviani, Ratna; Jusup, Sinu Andhi; Indarto, Dono
Nexus Kedokteran Translasional Vol 4, No 1 (2015): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Background: Some heavy metals and organic solvents like toluene and formaldehydeare hazardous chemicals that are usually used to paint furniture.These compounds may increase oxidative stress andassociatewithseveraldiseases.Oxidative stress is characterized by high levels of free radicals, which induce macromolecule oxidation including lipid. Lipid is oxidized to become reactive and toxic compounds like ethane and MDA. This study aimed to investigatethedifferences ofplasma MDA levels between furniture painters and non-painters. Method:This study was analytical observationwithcross sectional research design. Thisstudywas conducted in several furniture industries in Taunan, Jepara. 14 people who work as furniture painters were classified as the painter group and 14 people who work as non-furniture painters become the control group. The plasma MDA levels were measured by using Thiobarbituric Acid ReactiveSubstances(TBARS) test. The collected data was statistically analyzed by using student t and multiple linear regression tests. Result:The majority of people in painter group aged between 20-34 years old and was younger than that of control group (25-39 years old). A significant increase in MDA levels was observed in the painter group, compared with MDA levels of the control group (5.74 ±0.39 vs. 1.94 ±0.33 µmol/L) with p value <0.001. Paint exposure was significantly associated with plasma MDA levels (r = 0,968; = 96,80%; p<0,001).Other factors such as nutritional status, food, psychic, sports and air pollutants had small proportion (3.20%) to increase the MDA levels. Conclusion:Plasma MDA levels of furniture painters increased approximately three-fold and are positively related to paint chemical exposure. This data suggests the possibility of oxidative stressin furniture painters although its pathogenesis needs further investigation. Keywords: Furniture painters,oxidativestress, plasma MDA level 
Identification of Herbal Compounds as Thymidylate Synthase Inhibitors that more Potent than 5-Fluorouracil using Molecular Docking Pratama, Yoga Mulia; Indarto, Dono; Suselo, Yuliana Heri
Nexus Kedokteran Translasional Vol 4, No 2 (2015): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: Development of new selective anticancer drug is an important necessary. Because of that, some effective way to screen herbal compounds which have good potency for developing drug is needed, one of them is using molecular docking methods. In this study, researchers identify herbal compounds as new thymidylate synthase (TS) inhibitors which more potent than 5-Fluorouracil (5-FU) using molecular docking. Methods: Three-dimensional structure samples of herbal compounds from Indonesian herbal database (herbaldb.ui.ac.id) were docked with three-dimensional structure of TS protein using iGEMDOCK program. Then, the compounds which have lower docking score than fdUMP, as standard ligand, clustered using ChemMine. Results: The docking result showed that 27 herbal compounds have docking score lower than fdUMP in iGEMDOCK program. The 27 compounds have higher affinity to fdUMP and it can form a stable complex with TS protein. Protein-ligand complexes showed that all of 27 compounds have same binding site with fdUMP. But folic acid is excluded from the result because it is a TS ligand. fdUMP has similar structure with UMP, a TS ligand, but folic acid which has lowest docking score is not similar with UMP. Conclusions: The 26 compounds, except folic acid, are more potent than 5-FU as TS inhibitors by docking study. Further study to delineate the effectivity of molecular docking is needed. Keywords: 5-Fluorouracil, herbal compound, molecular docking, thymidylate synthase
Application of Autodock Vina program version 1.1.2 for Exploring Indonesian Phytochemicals as an Activator of Adenosine Monophosphate-Activated Protein Kinase Azzumar, Farchan; Indarto, Dono; ., Balgis
Nexus Kedokteran Translasional Vol 4, No 2 (2015): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Background: Increased activity of Adenosine Monophosphate-Activated Protein Kinase (AMPK) can inhibit cell growth and biosynthetic pathwaysin some cancer cells. Recently, several endogenous ligands have been identified to activate AMPK including Adenosine Monophosphate (AMP).Virtual screening is one of the recent technique, which is used for drug discoveries.Therefore the aim of this study was to identify active compounds of Indonesian herbal plants that activate AMPK by using molecular docking. Methods: Samples used in this study wereall of active compounds which were derived from Indonesian herbal plantsand had three-dimensional structures. Molecular docking was performed by using AutodockVina version 1.1.2 to evaluate interaction between AMPK and active compounds. The AMP structure obtained from protein data bank (www.rcsb.org/pdb)was used as a molecule standard of AMPK interaction. Docking score indicated affinity of molecule interaction and was determined in Cal/mol. To visualize docking results that fit to the AMPK molecule, chimera software version 1.9 was used. Results: Curcumin has docking scores as same as docking score of AMP (-7.5 Cal/mol) and has hydrogen bound in γ subunit of AMPK (Thr86, Thr88, and Arg117). Conclusions: Curcumin might be an activator of AMPK. Another molecular docking which has a flexible substrate-enzyme algorithm is required for confirming the docking result. Keywords: AMPK, Herbal plant, Molecular Docking.  
Metformin Enhances Anti-proliferative Effect of Cisplatin in Cervical Cancer Cell Line Yudhani, Ratih D.; Pesik, Riza N.; Indarto, Dono
Indonesian Journal of Clinical Pharmacy Vol 5, No 2 (2016)
Publisher : Indonesian Journal of Clinical Pharmacy

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Abstract

Cervival cancer is one of the top rank of gynecological malignancy in the world, leading to high morbidity and mortality rates. Cisplatin is a chemotherapeutic agent that is generally used to treat cervical cancer but the use of this drug is limited because of serious side effects. Metformin, a diabetic drug, decreases not only blood glucose levels but also cell viability of some cancer cells. The aim of this study was to investigate the anti-proliferative effect of combination metformin and cisplatin in HeLa cells (cervical cancer cell line). Anti-proliferative effect of these combined drugs was analized using MTT assay, combination index assay and HeLa cell morphology. Inhibitory concentration (IC50) of cisplatin and metformin was determined before performing combination index assay. Administration of 10 mM metformin showed inhibition of HeLa cell proliferation and it reached 50% inhibition of cell proliferation at 60 mM. Whilst, cisplatin showed a stronger anti-proliferative effect with initial inhibition dose at 12 μM and IC50 dose at 44 μM. Combination of 30 mM metformin and 5 μM cisplatin indicated the strongest anti-proliferative effect on HeLa cell. In conclusion, metformin may become a promising drug for treatment of cervical cancer in future which enhances anti-proliferative effect of cisplatin.Key words: Anti-proliferative effect, combination index, cervical cancer, cisplatin, metformin Peningkatan Efek Anti-poliferatif Cisplatin oleh Metformin pada Cell Line Kanker Serviks Kanker serviks merupakan salah satu keganasan ginekologi tertinggi di dunia, dengan tingkat morbiditas dan mortalitas yang tinggi. Cisplatin merupakan obat kemoterapi yang umum digunakan untuk terapi kanker serviks, namun penggunaannya relatif terbatas karena menyebabkan beberapa efek samping yang serius. Metformin merupakan obat anti diabetik yang mampu menurunkan kadar glukosa darah dan juga mampu menurunkan viabilitas beberapa jenis sel kanker. Penelitian ini bertujuan untuk mengetahui efek anti-proliferasi kombinasi metformin dan cisplatin pada sel HeLa (cell line kanker serviks). Efek anti-proliferasi kombinasi kedua senyawa tersebut dianalisis melalui MTT assay, combination index assay dan morfologi sel HeLa. Nilai inhibitory concentration (IC50) metformin dan cisplatin pada sel HeLa ditentukan lebih dahulu sebelum melakukan combination index assay. Pemberian metformin 10 mM mulai menunjukkan penghambatan proliferasi sel HeLa dan penghambatan proliferasi sel mencapai 50% pada dosis 60 mM. Cisplatin menunjukkan efek anti-proliferasi yang lebih kuat dengan dosis awal penghambatan sebesar 12 μM dan IC50 sebesar 44 μM. Kombinasi antara metformin 30 mM dan cisplatin 5 μM memperlihatkan efek anti-proliferatif terkuat pada sel HeLa. Sebagai kesimpulan, metformin kemungkinan menjadi obat yang menjanjikan untuk terapi kanker serviks di masa mendatang dengan cara meningkatkan efek anti-proliferasi cisplatin.Kata kunci: Cisplatin, combination index, efek anti-proliferatif, kanker serviks, metformin
HUBUNGAN STATUS GIZI LEBIH DAN LAMA MENSTRUASI DENGAN KEJADIAN ANEMIA PADA SISWI SMA DI KABUPATEN BOYOLALI Sandy, Yatty Destani; Tamtomo, Didik Gunawan; Indarto, Dono
Jurnal Gizi dan Kesehatan Vol 2, No 2 (2015)
Publisher : Program Studi Ilmu Gizi Pascasarjana Universitas Sebelas Maret

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Abstract

Abstrak Latar Belakang: Anemia pada remaja merupakan salah satu masalah kesehatan global. Anemia dapat disebabkan oleh rendahnya asupan besi, status gizi lebih, usia menarche dini dan kehilangan darah. Siswi dengan status gizi lebih dapat mengalami anemia karena akumulasi lemak dalam jaringan adiposa yang dapat meningkatkan produksi sitokin proinflamasi. Peningkatan kadar sitokin tersebut menyebabkan kadar hepsidin meningkat sehingga menurunkan absorbsi besi. Tujuan: Menganalisis hubungan status gizi lebih, usia menarche dan lama menstruasi dengan kejadian anemia pada siswi SMA di Kabupaten Boyolali. Metode: Jenis penelitian ini adalah observasional analitik dengan desain cross sectional. Teknik sampling menggunakan Multi Stage Sampling untuk menentukan subjek penelitian pada siswi kelas X. Pengumpulan data usia menarche dan lama menstruasi menggunakan kuisioner, status gizi diukur dengan antopometri, pengukuran kadar Hemoglobin menggunakan metode cyanmethemoglobin. Data yang dikumpulkan dianalisis menggunakan uji statistik chi square dan regresi logistik berganda. Hasil: Sebanyak 53,3% siswi mengalami anemia. Obesitas ditemukan sebesar 87,8% pada siswi dengan status gizi lebih. Siswi yang memiliki status gizi lebih berisiko secara signifikan sebesar 6,273 kali untuk mengalami anemia (p = 0,013). Semakin lama seorang siswi mengalami haid akan berisiko 4,848 kali untuk mengalami anemia (p = 0,003). Simpulan: Status gizi lebih dan lama menstruasi secara bersama sama berhubungan positif dengan kejadian anemia. Siswi diharapkan dapat mengontrol berat badan dan menghindari makanan yang dapat mengganggu penyerapan zat besi, perlu penyediaan suplementasi zat besi disekolah. Kata Kunci: Status gizi Lebih, Usia Menarche, Lama Menstruasi, Anemia.
Risk of Hypertension in Adolescents with Over Nutritional Status in Pangkalpinang, Indonesia Yusrizal, Mirza; Indarto, Dono; Akhyar, Muhammad
Journal of Epidemiology and Public Health Vol 1, No 1 (2016)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Adolescents are the changes of children to be adults. Gender, family history of disease, age, sodium intake and physical activity affect the pravelence of hypertensionAdolescences are the time change from children into adults. Gender, family history of disease, body mass index or BMI according to age, sodium intake and physical activity affect the prevalence of hypertension in adulthood.  Hypertension disorders in teenagers most will settle on adulthood. This study aimed to analyze risk factors of hypertension in adolescent aged 15-17 years with over nutritional status.Subject and Methods: This was an observational analytic study with cross sectional design. This was conducted in Pangkalpinang, Bangka Belitung Indonesia. A total of 120 students in grade X-XI in four high schools were selected by fixed-exposure sampling. BMI measurement used antropometri. Physical activity questionnaire used International Physical Activity Questionnaire. Sodium intake was measured with a food frequency questionnaire. Blood pressure was measured by using a sphygmomanometer. Data analysis was using a multiple linear regression.Results:  Gender and nutritional status more positively associated with hypertension, (B = 5.77; p = 0.017) and (B = 4.85; p = 0.001), while sodium intake,  family disease history and physical activity have a negative relationship, (B = 0.01; p = < 0.076),  (B =-1.73; p = 0.481) and (B = >-0.01; p = 0.592). Multiple linear analysis obtained adjusted R2 = 0356 (35.6%).Conclusions: Young men have a higher average blood pressure than women of 5.77 mmHg. Any increase of 1 kg/m2 equivalent BMI will raise the blood pressure of 4.85 mmHg. Adolescents with more nutritional status can increase knowledge about hypertension, as well as regulate eating habits according to needs of physical growth and development.Keywords: hypertension, adolescent, gender, family history of disease, BMI, sodium intake, physical activity.Correspondence: Mirza Yusrizal. Health Department of Pangkalpinang, Bangka Belitung, Indonesia. Email: mirzayusrizal@yahoo.co.idJournal of Epidemiology and Public Health (2016), 1(1): 27-36https://doi.org/10.26911/jepublichealth.2016.01.01.04 
Maternal Employment Status, Ethnicity, Food Intake, and Their Effects on Teenage Obesity, in Surakarta Susanti, Rahmah Purwaningsih Febri; Murti, Bhisma; Indarto, Dono
Journal of Epidemiology and Public Health Vol 1, No 2 (2016)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Background: Obesity is one of the main causesof premature death in adulthood. The prevalence of teenage obesity in Indonesia hasbeen increasing from 1.4% in 2007 to 7.3%. It is hypothesized that the risk of obesity is influenced by lifestyle and socio-economic status. This study aimed to determine the effect of maternal job status, ethnicity, and food intake, on the risk of obesity in teenagers.Subjects and Method: This was an analytical observational using case-control design. This study was conducted in Surakarta, in September – November 2016. A total of 120 teenagers were selected for the study, consisting of 41obese teenagers aged 16-18 years old and 79 normal weight teenagers, using fixed disease sampling. The dependent variable was obesity. The independent variables were maternal employment status, ethnicity, carbohydrate intake, fat intake, and energy intake. The data were collected using a set of questionnaires. Food intake was measured by 24 hour food recall. The data were analyzed using path analysis model.Results: Energy intake had positive, significant, and direct effect on the risk of teenage obesity (b = 6.75; 95%CI = 4.36 to 9.14; p = <0.001). Working mother indirectly had positive and significant effect on teenage obesity, via fat intake (b=0.77; 95% CI = 0.03 to 1.52; p=0.040). Fat intake indirectly had positive and significant effect on teenage obesity, via energy intake (b=4.16; 95%CI=1.95 to 6.38; p=0.001). Likewise, carbohydrateintake had positive and significant effect on teenage obesity, via energy intake(b = 3.31; 95% CI= 1.73 to 4.88; p = 0.001). Ethnicity (Chinese versus Javanese) did not have significant effect on teenage obesity (b =-1.14; 95% CI =-3.56 to 1.28; p = 0.355).Conclusion: Energy intake has direct effect on the risk of teenage obesity. Fat intake, carbohydrate intake, and maternal employment status, have indirect effect on the risk of teenage obesity.Keywords: maternal employment status, ethnicity,food intake, obesity, teenager.Correspondence: Rahmah Purwaningsih Febri Susanti. Master Program in Public Health Sebelas Maret University. Email: rahmahpfs77@gmail.comJournal of Epidemiology and Public Health (2016), 1(2): 75-85https://doi.org/10.26911/jepublichealth.2016.01.02.01
Bio-psychosocial Determinants of Quality of Life in the Elderly Prasetyaningsih, Roh Hastuti; Indarto, Dono; Akhyar, Muhammad
Journal of Epidemiology and Public Health Vol 1, No 2 (2016)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Background: The quality of life of elderly people has become relevant with the demographic shift that has resulted in greying of population. In Indonesia the number of old people has been increasing rapidly. Despite longer life span, this situation poses quality of life concern. It is then of interest to study determinants of quality of life in the elderly, so that necessary measures can be taken to improve the quality of life in the elderly. This study aimed to examined bio-psichosocial factors associated with the quality of life in the elderly.Subjects and Method: This was an analytic observational study using case control design. This study was conducted in Laweyan and Banjarsari, Surakarta. A total of 141 elderly consisting of 47 elderly who lived in the nursing home and 94 elderly who lived at their own home, were selected for this study, by fixed exposure sampling. The independent variables were age, education, income, family support, residential status, and depression. The dependent variables was quality of life. The data were collected with a set of questionnaire and analyzed using path analysis model.Results: As many as 40.4% of the elderly studied had good quality of life. Higher income (b = 0.93; 95%CI = 0.06 to 1.86; p = 0.048) and education (b=0.82; 95%CI= -0.01 to 1.66; p= 0.053) is associated with better quality of life. Depression (b =-1.01; 95%CI =-1.78 to -0.23; p = 0.010) and age ≥ 60 years old (b=-0.47; 95% CI= -1.28 to 0.33; p= 0.249). Living at own home decreased depression, higher education increased income, family support increased living at home.Conclusion: Income and education increase the quality of life. Depression and older age decrease the quality of life.Key words: bio-psychosocial, quality of life, elderlyCorrespondence: Roh hastuti Prasetyaningsih. Health Polytechnics, Poltekkes Surakarta, Central JavaJournal of Epidemiology and Public Health (2016), 1(2): 108-117https://doi.org/10.26911/jepublichealth.2016.01.02.04
Path Analysis on the Effects of Bio-psychosocial Factors and Calorie Intake in Blood Glucose Control in Patients with Type 2 Diabetes Mellitus -, Isfaizah; Murti, Bhisma; Indarto, Dono
Indonesian Journal of Medicine Vol 1, No 2 (2016)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Diabetes mellitus (DM) is a serious chronic disease with its tendency to deteriorate. The DM cases worldwide in 2015 was 415 million people and it is estimated to increase as many as 642 million cases in 2040. Indonesia ranked 7 in the world with 10 million cases of DM in 2015, about 90% of which were Type 2 Diabetes Mellitus. This study aimed to determine the effect of biopsychosocial factors and calorie intake on the blood glucose control in patients with Type 2 DM.Subjects and Method: This was an analytic and observational study with case control design. This study was carried out at Internal Medicine Polyclinic, Department of Endocrinology, Dr. Moewardi Hospital, Surakarta, Central Java, from October to November 2016. A total sample of 135 cases of Type 2 DM were selected for this study by fixed disease sampling. As many as 106 of these study subjects at  HbA1c ≥6.5% and 29 cases of Type 2 DM had HbA1c <6.5%. The dependent variable was HbA1c level. The independent variables were educational level, family income, psychological stress, calorie intake, and Body Mass Index (BMI). The data were collected by a set of questionnaire. HbA1c was measured by High Performance Liquid Chromatography (HPLC), which was recorded in the medical record. Calorie intake was measured by 24 hour food recall. Psychological stress was measured by International Physical Activity Questionnaire (IPAQ). The data was analyzed by path analysis on STATA 13.Results: Psychological stress (b=0.99, 95%CI=0.07 to 1.92, p=0.034), calorie intake (b= 1.84, 95%CI= -0.24 to 3.92, p=0.083), and BMI (b= 1.15, 95%CI= 0.22 to 2.08, p=0.016), had positive and statistically significant effect on HbA1c. Calorie intake increased BMI (b= 2.35, 95%CI=0.31 to 4.39, p=0.024), education decreased calorie intake (b=-2.26, 95%CI= -3.38 to -1.14, p<0.001), and family income increased calorie intake (b= 1.23, 95%CI= 0.26 to 2.21, p= 0.013).Conclusion: Calorie intake, BMI, psychologi stress, and family income are associated with increase in HbA1c level. Education decreases HbA1c level via decreased calorie intake. Type 2 DM patients need to pay attention to these biopsychosocial factors and calorie intake in order to control blood sugar.Keywords: biopsychosocial factors, calorie intake, HbA1cCorrespondence: Isfaizah. Ngudi WaluyoUniversity, Ungaran, Central Java. Email: is.faizah84@yahoo.com. Mobile: +6281228570003.Indonesian Journal of Medicine (2016), 1(2): 90-99https://doi.org/10.26911/theijmed.2016.01.02.02
Co-Authors ., Hudiyono A.A. Ketut Agung Cahyawan W Adam Haviyan Nasrullah Adi Prayitno Afdhaliya, Noor Khalwati Agus Kristiyanto Ahmad Hamim Sadewa Akbar, Muh. Syaiful Ali Djamhuri Ambar Mudigdo Amilia Yuni Damayanti Andina, Puri Dwi Argyo Demartoto, Argyo Ari Natalia Probandari Arief Suryono Arta Farmawati Asti Swari Paramanindita Astri Purwanti Avelia, Annisa Ayusari, Amelya Augusthina Azizah, Shofura Azzumar, Farchan Badri, Baarizah Febriana Balgis . Balgis . Balgis Balgis Balgis Balgis Bambang Purwanto Baruroh, Durotul Bhisma Murti Brian Wasita Brian Wasita Brian Wasita Brian Wasita Budianto, Pepi Budiyanti Wiboworini Budiyanti, Novita Damayanti, Ana Dandi Sanjaya Dea Linia Romadhoni Dewi, Dwi Hananta Diah Kurnia Mirawati Dian Eka Widyasari Didik Gunawan Tamtomo Didik Gunawan Tamtomo Didik T Subekti Didik Tamtomo, Didik Diffah Hanim Diffah Hanim Diffah Hanim Diffah Hanim Diffah Hanim Dina Okfina Ria Dinar Putri Rahmawati Diyantana, Wawan Endang Sutisna Sulaeman Ernawati Ernawati Eti Poncorini Pamungkasari Fadhila Balqis Nurfitria Fajar Alam Putra, Fajar Alam Fara Ayu Febyawati, Hani Farchan Azzumar Firdaus, Jihan Fitriana Fitriana Gilang Akbar Shobirin Gracia, Vera Viviana Deo Hambarsari, Yetty Hamidi, Baarid Luqman Hani Fara Ayu Febyawati Hartono Hartono Hastami, Yunia Hastuti, Nunik Maya Hermanu Joebagio Heru Sulastomo Herviana, Herviana Hudiyono . Hutabarat, Ervina Arta Jayanti Ida Ayu Putu Sri Widnyani Ida Nurwati Ida Nurwati Inayati Inayati Indah Kusumawati Irma Isnafia Arief Isfaizah Isti Sundari Iwansyah, Ade Chandra Jatmiko Susilo Jatu Aphridasari Jusup, Sinu Andhi Jusup, Sinu Andhi K Kusnandar Kezia Elian Devina Kurniagung, Philipus Prihantiko Kusnandar Kusnandar Kusnandar, K Kusumadewi Eka Damayanti Kusumadewi Eka Damayanti Kusumadewi Eka Damayanti Laksana, Budi Liana, Gladya Lady Lilik Wijayanti Luberta Ebta Wiyani M Rizal Permadi M. Yogi Riyantama Isjoni Mahendra Wijaya Martha Arum Nugraheni Maryati, Warsi Mashuri, Yusuf Ari Mila Ulfia Muchsin Doewes Muhammad, Faizal Nanda Eka Sri Sejati Nasrullah, Adam Haviyan Ningrum, Sri Setiyo NINGRUM, TYAS SARI RATNA Niniek Purwaningtyas Noor Khalwati Afdhaliya Nor Istiqomah Nor Istiqomah Nor Istiqomah Nugroho, Anung N. Nunuk Suryani Nurfitria, Fadhila Balqis Nurinasari, Hafi Nurochim, Erna Nurwati, Ida Nurwijayanti Oktaviani, Ratna Pamungkasari, Eti P. Paramasari Dirgahayu Paramasari Dirgahayu Perdana, Muhammad Vidi Pesik, Riza N. Prabaningtyas, Hanindia Riani Prahesti, Ratna Prasetyaningsih, Roh Hastuti Pratama, Yoga Mulia PRATHITA NITYASEWAKA Pratiwi, Ayudhia Purnama, Siswanta Jaka Purwaningsih, Yustina Puspita, Rumeyda Chitra Putri, Anak Agung Alit Kirti Estuti Narendra Putri, Risma Aliviani Putri, Widya Kaharani R. Aj. Sri Wulandari Rahardjo, Setyo Sri Rahardjo, Setyo Sri RAJ Sri Wulandari Ratih D. Yudhani Ratna Kusumawati Ratna Kusumawati Ratna Oktaviani Retiyansa, Yesi Retiyansa, Yesi Reviono Reviono Ristinawati, Ira Risya Cilmiaty AR Risya Cilmiaty, Risya Rivan Danuaji Riza N. Pesik Riza Novierta Pesik Riza Novierta Pesik RUBEN DHARMAWAN Sajidan Sarah Safira Umarghanies Sari, Septi Ayu Arum Yuspita Satriani, Hayu Andita Sejati, Nanda Eka Sri Selfi Handayani Selfi Handayani Sena, Anantha Setyaningrum, Th. Catur Wulan Setyo Sri Rahardjo Shanti Listyawati Sinu Andhi Jusup Soetrisno Soetrisno Soetrisno Sri Sulistyowati Sri Wulandari Sugiarto - Sugiarto S Sugiarto Sugiarto Sugiarto Sugiarto Suminah Suminah Sunarto Tetes Lugito Sundari, Isti Suradi Suradi SUROTO SURYAWATI, BETTY Susanti, Rahmah Purwaningsih Febri Suselo, Yuliana Heri Suselo, Yuliana Heri Suselo, Yuliana Heri Susilawati, Eva Tamtomo, Didik Gunawan Tedjo, Raden Andi Ario Tejomukti, Teddy Thesman, Inggrit Bela Tiyas, Dwi Wahyuning Tonang Dwi Ardyanto Tri Agustina Tri Agustina, Tri Tri Harsono Tri Harsono Tri Nugraha Susilawati Ulfia, Mila Umarghanies, Sarah Safira Utami, Agustina Dwi Vitri Widyaningsih Vitria Sari Dewi Vitria Sari Dewi Wahyuni, Ardianti Wardhani, Lusi Oka Wariyanti, Astri Sri Widiasih, Ghina Widyanti, Fera Wijayanti, Poppy Winda Rizki Pebrina Batubara Wulandari, R. AJ. Sri Wulandari, RAJ Sri Yarso, Kristanto Y. Yatty Destani Sandy Yoga Mulia Pratama Yudhani, Ratih D. yulia lanti retno dewi Yuliana Heri Soesilo Yuliana Heri Soesilo Yuliana Heri Soesilo Yuliana Heri Suselo Yuliana Heri Suselo Yunilla Prabandari Yusrizal, Mirza