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Peningkatan Pengetahuan Faktor-Faktor yang Memengaruhi Perilaku Seks dalam Upaya Cegah Seks Pranikah pada Siswa-Siswi SMP N 77 dan SMA N 77 Jakarta Pusat Tri Panjiasih Susmiarsih; Himmi Marsiati; Susi Endrini
Jurnal Pengabdian kepada Masyarakat (Indonesian Journal of Community Engagement) Vol 4, No 2 (2019): Maret
Publisher : Direktorat Pengabdian kepada Masyarakat Universitas Gadjah Mada

ABSTRACT The premarital sex behavior is a problem and social phenomenon that is increasingly prevalent in society. At a young age, the premarital sex should be a major concern to reduce pregnancy rates unintended, sexually transmitted diseases, school drop out, abortion and even a death. One effort to prevent the premarital sex behavior for students in schools with methods of providing knowledge about sexual behavior, reproductive health, an understanding of religious and the early marriage law. Evaluation of indicators usingpre test and post test data that are analyzed with paired t and regression test. The results show that after counseling, the knowledge of junior high school students about sexual behavior, reproductive health and religious knowledge increased significantly (p <0.05), while high school students of religious knowledge and early marriage law increased significantly. Keywords: premarital sex; reproductive health; sexual behavior

Relationship Between Maternal Education and Knowledge on Coverage of Exclusive Breastfeeding in Ten Stunting Locus Villages in Pandeglang District, Banten Sri Wuryanti; Himmi Marsiati
Indonesian Journal of Medical Sciences and Public Health Vol 2 No 1 (2021)
Publisher : Future Science

Introduction: Until now, the practice of exclusive breastfeeding is still far from the national target. The success of exclusive breastfeeding is determined by many factors, including the mother’s education, knowledge, and awareness about the importance of breastfeeding for child growth. This study aims to determine the relationship between the mother’s level of education and knowledge on exclusive breastfeeding in ten stunting locus villages located in Pandeglang Regency, Banten, Indonesia. Methods: This study uses a cross-sectional design with data collection methods through interviews and direct observation. The population consists of mothers who have children under 2 years of age. The study was conducted for 6 months from November 2019. The variables studied included the mother’s age, occupation, number of children, education, and knowledge of exclusive breastfeeding. Result: As many as 99.6% of respondents have a good level of knowledge about exclusive breastfeeding. The level of education is low at 44.6%, medium at 50.9%, and high at 4.4%. The results showed there was no significant relationship between the mother’s last education and exclusive breastfeeding (p = 0.860) and there was no significant relationship between the mother's level of knowledge and exclusive breastfeeding (p = 0.558). Conclusion: No significant relationship was observed between the mother’s education and knowledge on exclusive breastfeeding in ten stunting locus villages located in Pandeglang Regency, Banten.

AKTIVITAS ANTIOKSIDAN KOMBINASI DAUN MATOA (Pometia pinnata) DAN DAUN SIRSAK (Annona muricata L.) MENGGUNAKAN METODE DPPH DENGAN BERBAGAI PELARUT: ANTIOXIDANT ACTIVITY OF MATOA LEAVES (Pometia pinnata) AND SOURSOP LEAVES (Annona muricata L.) USING DPPH METHOD WITH VARIOUS SOLVENTS Carolin Aprilia Baslani; Himmi Marsiati; Sri Wuryanti
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 2 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i2.717

Penggunaan obat herbal dinilai lebih aman daripada penggunaan obat modern. Hal ini disebabkan karena obat tradisional memiliki efek samping yang relatif lebih sedikit daripada obat modern. Daun matoa dan daun sirsak memiliki senyawa fenolik yang berperan sebagai antioksidan alami. Penelitian ini bertujuan untuk mengetahui nilai aktivitas antioksidan daun matoa, daun sirsak, dan kombinasi keduanya dengan berbagai pelarut yaitu etanol 96%, etil asetat, dan air. Ekstrak daun matoa dan daun sirsak dibuat dengan metode maserasi selama 3x24 jam, menggunakan pelarut etanol 96%. Setelah diperoleh ekstrak kental, difraksinasi dengan aquades dan etil asetat diulangi sebanyak 3x, pembuatan ekstrak kombinasi digunakan perbandingan 1:1. Uji aktivitas antioksidan dengan metode DPPH menggunakan spektrofotometri UV-Visibel. Lalu dilakukan skrining fitokimia menggunakan senyawa fenolik, flavonoid, triterpenoid, saponin, dan tanin. Hasil skrining fitokimia menunjukkan ekstrak daun matoa dan daun sirsak positif mengandung fenolik, flavonoid, dan tanin. Hasil penelitian ini mendapatkan nilai IC50 dari ekstrak etanol daun matoa sebesar 5,46 ppm yang dikategorikan sangat kuat sedangkan ekstrak etil asetat daun sirsak 5,40 ppm yang juga di kategorikan sangat kuat. Kombinasi kedua ekstrak memiliki nilai IC50 4,39 ppm lebih kuat daripada ekstrak tunggal. Menunjukan kombinasi daun matoa dan daun sirsak berpotensi menjadi agen antioksidan alami. Kata kunci : antioksidan, matoa (Pometia pinnata), sirsak (Annona muricata L.), kombinasi, DPPH, IC50, fitokimia.

Uji Aktivitas Antioksidan dan Profil Fitokimia Biji Kopi Robusta (Coffea canephora), Biji Vanili (Vanila planifolia), dan Kombinasi Keduanya dengan Bermacam Pelarut: Tests of Antioxidant Activity and Phytochemical Profile of Robusta Coffe Seeds (Coffe canephora), Vanilla Seeds (Vanila planifolia), and the Combination of the Both With Various Solvents Muhammad Andre Niljon; Himmi Marsiati
Jurnal Surya Medika (JSM) Vol. 9 No. 2 (2023): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v9i2.4612

Robusta coffee (Coffea canephora) and vanilla fruit (Vanila planifolia) are plants that contain antioxidants. The aim of the study was to determine the antioxidant activity of these plants and their combination. Activity was measured using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method on ethanol, ethyl acetate, and water extracts. The results of the research on vanilla fruit had an IC50 value of 153.09 ppm in ethanol extract, IC50 176.69 ppm in ethyl acetate extract, and IC50 245.28 ppm in aqueous extract. Robusta coffee beans have an IC50 value of 18.96 ppm in the ethanol extract, an IC50 of 27.03 ppm in the ethyl acetate extract, and an IC50 of 20.13 ppm in the aqueous extract. The combination of vanilla and coffee had an IC50 value of 39.40 ppm for the ethanol extract, an IC50 of 41.25 ppm for the ethyl acetate extract, and an IC50 of 38.60 ppm for the aqueous extract. Vitamin C as a standard for comparison has an IC50 value of 2.99 ppm. The ANOVA test results showed a value of p <0.05 which indicated that there were significant differences between samples with various solvents. Phytochemical tests showed that vanilla contain flavonoids and phenolics.

AKTIVITAS ANTIOKSIDAN KOMBINASI DAUN MATOA (Pometia pinnata) DAN DAUN SIRSAK (Annona muricata L.) MENGGUNAKAN METODE DPPH DENGAN BERBAGAI PELARUT: ANTIOXIDANT ACTIVITY OF MATOA LEAVES (Pometia pinnata) AND SOURSOP LEAVES (Annona muricata L.) USING DPPH METHOD WITH VARIOUS SOLVENTS Carolin Aprilia Baslani; Himmi Marsiati; Sri Wuryanti
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 2 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i2.717

Penggunaan obat herbal dinilai lebih aman daripada penggunaan obat modern. Hal ini disebabkan karena obat tradisional memiliki efek samping yang relatif lebih sedikit daripada obat modern. Daun matoa dan daun sirsak memiliki senyawa fenolik yang berperan sebagai antioksidan alami. Penelitian ini bertujuan untuk mengetahui nilai aktivitas antioksidan daun matoa, daun sirsak, dan kombinasi keduanya dengan berbagai pelarut yaitu etanol 96%, etil asetat, dan air. Ekstrak daun matoa dan daun sirsak dibuat dengan metode maserasi selama 3x24 jam, menggunakan pelarut etanol 96%. Setelah diperoleh ekstrak kental, difraksinasi dengan aquades dan etil asetat diulangi sebanyak 3x, pembuatan ekstrak kombinasi digunakan perbandingan 1:1. Uji aktivitas antioksidan dengan metode DPPH menggunakan spektrofotometri UV-Visibel. Lalu dilakukan skrining fitokimia menggunakan senyawa fenolik, flavonoid, triterpenoid, saponin, dan tanin. Hasil skrining fitokimia menunjukkan ekstrak daun matoa dan daun sirsak positif mengandung fenolik, flavonoid, dan tanin. Hasil penelitian ini mendapatkan nilai IC50 dari ekstrak etanol daun matoa sebesar 5,46 ppm yang dikategorikan sangat kuat sedangkan ekstrak etil asetat daun sirsak 5,40 ppm yang juga di kategorikan sangat kuat. Kombinasi kedua ekstrak memiliki nilai IC50 4,39 ppm lebih kuat daripada ekstrak tunggal. Menunjukan kombinasi daun matoa dan daun sirsak berpotensi menjadi agen antioksidan alami. Kata kunci : antioksidan, matoa (Pometia pinnata), sirsak (Annona muricata L.), kombinasi, DPPH, IC50, fitokimia.

Antioxidant and Cytotoxic Activity Test of Srikaya (Annona squamosa L.) Leaves and Matoa (Pometia pinnata) Leaves Extract Combination on Oral Squamous Carcinoma Cells (HSC-3) Putri Arifa Izzati; Himmi Marsiati
Jurnal Indonesia Sosial Sains Vol. 6 No. 2 (2025): Jurnal Indonesia Sosial Sains
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jiss.v6i2.1608

Oral cancer, particularly oral squamous cell carcinoma, is a prevalent and lethal disease that often metastasizes to surrounding tissues. Traditional treatments such as surgery, radiotherapy, and chemotherapy present various side effects, necessitating the exploration of alternative therapies. This study aims to determine the antioxidant value of the combination of ethanol extracts of srikaya leaves (Annona squamosa L) and matoa leaves (Pometia pinnata) against HSC-3 cell cytotoxicity. The antioxidant test on the combination of ethanol extracts of srikaya leaves and matoa leaves using DPPH assay to obtain IC50. HSC-3 cell lines were treated with a combination of ethanol extracts of srikaya leaves (Annona squamosa L) and matoa leaves (Pometia pinnata) with concentrations of 12.5 µl/ml, 25 µl/ml, 50 µl/ml, 100 µl/ml, and 200 µl/ml for 24 hours and tested with the CCK-8 assay method to calculate cell viability and obtain IC(50.The results of the antioxidant test of the combination of ethanol extracts of srikaya leaves (Annona squamosa L) and matoa leaves (Pometia pinnata) in the regression analysis results, obtained a significant value of p-Value = 0.033 <0.050, so it is stated that the concentration has a significant effect on inhibition. In the results of IC 50 obtained 7.62 µl / ml shows antioxidant activity is classified as very strong which is characterized by the value of IC 50 < 50 µl / ml. Statistical analysis using ANOVA followed by Tukey's HSD post hoc test obtained (p-Value = 0.000 with a correlation value of r = 0.599) means that the treatment given does not have a significant effect on the observation results. Ethanol extracts of srikaya leaves (Annona squamosa L) and matoa leaves (Pometia pinnata) have the potential to be made as a therapy using natural ingredients on anticancer HSC-3 cancer cells.

Edukasi Tuberkolosis dan Resistensi Obat TB Pada Warga dan Kader PKK RW 06 Balimester, Jakarta Timur Himmi Marsiati; Wening Sari; Sri Wuryanti; Sri Hastuti Andayani; Sabarina Elfrida Manik; Inas Hasna Azizah; Kamal Anas; Desi Aryani; Linda Weni; Hadiati Fitri; Munfaati; Yazid Zainur Isnen
Jurnal Abdimas Indonesia Vol. 5 No. 3 (2025)
Publisher : Perkumpulan Dosen Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34697/jai.v5i3.1878

Penyakit Tuberculosis masih menjadi ancaman kesehatan di Indonesia. Angka kejadian TB di Indonesia meningkat setiap tahun. Penderita TB yang tidak ditangani dengan baik dapat menyebabkan komplikasi hingga kematian. Selain itu, terapi yang tepat diberikan untuk menghindari bakteri resisten terhadap obat. Tujuan kegiatan ini adalah meningkatkan kesadaran masyarakat tentang bahaya penyakit TB dan TB resisten obat melalui edukasi. Metode yang dilakukan untuk kegitan pengabdian kepada masyarakat adalah melalui pemberian ceramah, pemberian pretest dan postes, dan pemeriksaan kadar Hb pada anak-anak. Berdasarkan hasil skor post test diketahui bahwa pengetahuan masyarakat meningkat setelah edukasi dilakukan.

Effect of Vitamin D Supplementation on Irisin, Telomerase, Klotho, and Tumor Necrosis Factor-alpha (TNF-α) in Elderly: A Quasi-Experimental Study Diniwati Mukhtar; Nunung Ainur Rahmah; Sri Wuryanti; Himmi Marsiati; Desi Ariyani Haddad; Sabarina Elfrida Manik; Linda Weni; Bistamy Muhammad Nursabur; Andrea Ivana Allicia Hutabarat; Switania Putri Puspita
Althea Medical Journal Vol 12, No 3 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n3.4286

Background: Vitamin D plays a crucial role in aging by regulating mitochondrial function, inflammation, oxidative stress, and telomere stability. Vitamin D deficiency is common among the elderly and is linked to accelerated aging. Biomarkers such as irisin, telomerase, klotho, and tumor necrosis factor-alpha (TNF-α) are associated with aging processes. This study aimed to evaluate the effect of vitamin D supplementation on these biomarkers in elderly individuals.Methods: This quasi-experimental pretest-posttest study was conducted in Kadugadung Village, Banten, Indonesia from Maret to September 2024. A total of 47 healthy elderly individuals (≥60 years) were recruited using purposive sampling. The treatment group (n=25) received 800 IU/day of vitamin D for 20 days, whereas the control group (n=22) received none. Blood samples were collected before and after the intervention to measure serum irisin, telomerase activity, klotho, and TNF-α. Baseline variables included body mass index (BMI), blood pressure, hemoglobin, hematocrit, blood glucose, cholesterol, and uric acid. Data were analyzed using paired and independent statistical tests.Results: Vitamin D supplementation significantly increased serum irisin levels (p=0.016), meanwhile no significant changes were observed in telomerase activity (p=0.128), klotho (p=0.819), or TNF-α (p=0.098). In the treatment group, blood glucose was correlated positively with TNF-α (r=0.423, p<0.05), whereas cholesterol was correlated negatively with TNF-α (r=-0.51, p<0.01). Furthermore, telomerase activity was correlated positively with irisin (r=0.348, p<0.05)Conclusion: Vitamin D supplementation at 800 IU/day significantly enhances serum irisin, but does not affect telomerase, klotho, or TNF-α. These findings suggest a potential role of vitamin D in modulating aging-related biomarkers. Correction Notice: This article has been corrected. See the Erratum published in Althea Medical Journal, Volume 12, Number 4 (2025).

Borassus flabellifer Effectively Reduces MDA Levels in High Oxidative Stress Population in Jakarta, Indonesia Reza Aditya Digambiro; Himmi Marsiati; Restu Syamsul Hadi; Edy Parwanto
Sumatera Medical Journal Vol. 8 No. 2 (2025): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v8i2.18966

Background: Malondialdehyde (MDA) is commonly used to assess oxidative stress levels. Objective: This study aimed to investigate the effect of Borassus flabellifer fruit consumption on MDA levels in individuals with high oxidative stress, providing insights into the fruit’s potential as a natural antioxidant therapy. Methods: A prospective interventional study was conducted in Jakarta, recruiting fifty participants aged 30–60 years with baseline MDA levels >10 nmol/L. Participants consumed 150 grams of Borassus flabellifer fruit daily for 30 days. Blood samples were collected at baseline and post-intervention to assess MDA levels. Results: The average MDA level decreased significantly from 14.35 ± 2.43 nmol/L to 12.00 ± 1.74 nmol/L after 30 days of fruit consumption (p < 0.0001). The Cohen’s d value of 2.92 indicated a large effect size, demonstrating the intervention’s substantial impact. A strong positive correlation (r = 0.91, p < 0.0001) between baseline MDA levels and reduction was observed, suggesting that participants with higher baseline oxidative stress benefited more from the intervention. Conclusion: Borassus flabellifer fruit consumption effectively reduces MDA levels in individuals with high oxidative stress. The results support the inclusion of this fruit in recommendations for managing oxidative stress-related conditions.

Akurasi Diagnostik Biomarker Stres Oksidatif, Profil Sitokin, dan Defisiensi Vitamin D dalam Memprediksi Derajat Preeklamsia: Sebuah Tinjauan Sistematis dan Meta-Analisis Raden Roro Pratiwi Madya Putri; Himmi Marsiati; Dicky Budiman; Sri Wuryanti
Journal of Innovative and Creativity (Joecy) Vol. 6 No. 2 (2026)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v6i2.11978

Latar Belakang: Preeklamsia merupakan sindrom multiorgan yang menjadi penyebab utama mortalitas maternal secara global akibat disfungsi endotel sistemik. Meskipun skrining dini preeklamsia telah diterapkan pada pelayanan kesehatan primer pada saat trimester 1 dan 3, angka kejadian kasus kegawatdaruratan pada trimester ketiga tetap tinggi akibat adanya diskrepansi hasil pemeriksaan protein urin dan variabilitas kompetensi diagnostik tenaga kesehatan. Tujuan: Penelitian ini bertujuan untuk mengevaluasi akurasi diagnostik kombinasi biomarker stres oksidatif, profil sitokin, dan defisiensi vitamin D dalam memprediksi tingkat derajat keparahan preeklamsia. Metode: Tinjauan sistematis dan meta-analisis ini telah dilakukan dengan menelaah artikel ilmiah dari pangkalan data elektronik melalui pendekatan bivariat. Objek penelitian difokuskan pada ibu hamil dengan risiko preeklamsia yang dinilai berdasarkan kadar parameter biologis serta faktor gaya hidup berupa paparan sinar matahari. Hasil: Analisis menunjukkan bahwa integrasi nilai malondialdehyde dan rasio sitokin pro-inflamasi memiliki sensitivitas serta spesifisitas yang tinggi dalam mendeteksi kerusakan endotel awal. Penurunan kadar vitamin D aktif terbukti secara signifikan memperberat inflamasi plasenta. Faktor luar seperti durasi berjemur yang kurang dari lima belas menit sehari ditemukan meningkatkan risiko defisiensi vitamin D pada ibu hamil. Gaya berpakaian yang terlalu tertutup tanpa kompensasi suplemen juga membatasi sintesis vitamin D3 oleh sinar ultraviolet B. Karakteristik nutrisi yang buruk dari makanan harian dilaporkan memperparah kondisi hipoksia jaringan. Penilaian ulang terhadap kompetensi tenaga kesehatan dalam melakukan anamnesis terbukti mendesak untuk ditingkatkan. Standardisasi uji protein urin menggunakan metode konfirmasi ulang (duplo) efektif menekan angka negatif palsu di fasilitas kesehatan tingkat pertama. Pelatihan ultrasonografi emergensi bagi dokter umum di unit gawat darurat terbukti mempercepat ketepatan rujukan kasus. Kesimpulan: Kombinasi biomarker molekuler dan penapisan faktor gaya hidup ditemukan akurat sebagai instrumen prediksi preeklamsia. Fasilitas kesehatan disarankan menerapkan standardisasi pemeriksaan laboratorium dan meningkatkan pelatihan klinis bagi dokter umum. Implikasi: Penerapan skrining berbasis biomarker dan edukasi preskripsi berjemur yang terukur dapat menurunkan angka keterlambatan rujukan serta menekan mortalitas pasien preeklamsia secara nyata di rumah sakit.

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