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All Journal Jurnal Surya Medika Indonesian Journal of Global Health research Jurnal Pengabdian Masyarakat Multidisiplin Medical Sains : Jurnal Ilmiah Kefarmasian Medical Sains : Jurnal Ilmiah Kefarmasian
Himmi Marsiati
Universitas Yarsi
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AKTIVITAS ANTIOKSIDAN KOMBINASI DAUN MATOA (Pometia pinnata) DAN DAUN SIRSAK (Annona muricata L.) MENGGUNAKAN METODE DPPH DENGAN BERBAGAI PELARUT: ANTIOXIDANT ACTIVITY OF MATOA LEAVES (Pometia pinnata) AND SOURSOP LEAVES (Annona muricata L.) USING DPPH METHOD WITH VARIOUS SOLVENTS Carolin Aprilia Baslani; Himmi Marsiati; Sri Wuryanti
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 2 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i2.717

Abstract

Penggunaan obat herbal dinilai lebih aman daripada penggunaan obat modern. Hal ini disebabkan karena obat tradisional memiliki efek samping yang relatif lebih sedikit daripada obat modern. Daun matoa dan daun sirsak memiliki senyawa fenolik yang berperan sebagai antioksidan alami. Penelitian ini bertujuan untuk mengetahui nilai aktivitas antioksidan daun matoa, daun sirsak, dan kombinasi keduanya dengan berbagai pelarut yaitu etanol 96%, etil asetat, dan air. Ekstrak daun matoa dan daun sirsak dibuat dengan metode maserasi selama 3x24 jam, menggunakan pelarut etanol 96%. Setelah diperoleh ekstrak kental, difraksinasi dengan aquades dan etil asetat diulangi sebanyak 3x, pembuatan ekstrak kombinasi digunakan perbandingan 1:1. Uji aktivitas antioksidan dengan metode DPPH menggunakan spektrofotometri UV-Visibel. Lalu dilakukan skrining fitokimia menggunakan senyawa fenolik, flavonoid, triterpenoid, saponin, dan tanin. Hasil skrining fitokimia menunjukkan ekstrak daun matoa dan daun sirsak positif mengandung fenolik, flavonoid, dan tanin. Hasil penelitian ini mendapatkan nilai IC50 dari ekstrak etanol daun matoa sebesar 5,46 ppm yang dikategorikan sangat kuat sedangkan ekstrak etil asetat daun sirsak 5,40 ppm yang juga di kategorikan sangat kuat. Kombinasi kedua ekstrak memiliki nilai  IC50 4,39 ppm lebih kuat daripada ekstrak tunggal. Menunjukan kombinasi daun matoa dan daun sirsak berpotensi menjadi agen antioksidan alami. Kata kunci : antioksidan, matoa (Pometia pinnata), sirsak (Annona muricata L.),  kombinasi, DPPH, IC50, fitokimia.
Uji Aktivitas Antioksidan dan Profil Fitokimia Biji Kopi Robusta (Coffea canephora), Biji Vanili (Vanila planifolia), dan Kombinasi Keduanya dengan Bermacam Pelarut: Tests of Antioxidant Activity and Phytochemical Profile of Robusta Coffe Seeds (Coffe canephora), Vanilla Seeds (Vanila planifolia), and the Combination of the Both With Various Solvents Muhammad Andre Niljon; Himmi Marsiati
Jurnal Surya Medika (JSM) Vol. 9 No. 2 (2023): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v9i2.4612

Abstract

Robusta coffee (Coffea canephora) and vanilla fruit (Vanila planifolia) are plants that contain antioxidants. The aim of the study was to determine the antioxidant activity of these plants and their combination. Activity was measured using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method on ethanol, ethyl acetate, and water extracts. The results of the research on vanilla fruit had an IC50 value of 153.09 ppm in ethanol extract, IC50 176.69 ppm in ethyl acetate extract, and IC50 245.28 ppm in aqueous extract. Robusta coffee beans have an IC50 value of 18.96 ppm in the ethanol extract, an IC50 of 27.03 ppm in the ethyl acetate extract, and an IC50 of 20.13 ppm in the aqueous extract. The combination of vanilla and coffee had an IC50 value of 39.40 ppm for the ethanol extract, an IC50 of 41.25 ppm for the ethyl acetate extract, and an IC50 of 38.60 ppm for the aqueous extract. Vitamin C as a standard for comparison has an IC50 value of 2.99 ppm. The ANOVA test results showed a value of p <0.05 which indicated that there were significant differences between samples with various solvents. Phytochemical tests showed that vanilla contain flavonoids and phenolics.
AKTIVITAS ANTIOKSIDAN KOMBINASI DAUN MATOA (Pometia pinnata) DAN DAUN SIRSAK (Annona muricata L.) MENGGUNAKAN METODE DPPH DENGAN BERBAGAI PELARUT: ANTIOXIDANT ACTIVITY OF MATOA LEAVES (Pometia pinnata) AND SOURSOP LEAVES (Annona muricata L.) USING DPPH METHOD WITH VARIOUS SOLVENTS Carolin Aprilia Baslani; Himmi Marsiati; Sri Wuryanti
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 2 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i2.717

Abstract

Penggunaan obat herbal dinilai lebih aman daripada penggunaan obat modern. Hal ini disebabkan karena obat tradisional memiliki efek samping yang relatif lebih sedikit daripada obat modern. Daun matoa dan daun sirsak memiliki senyawa fenolik yang berperan sebagai antioksidan alami. Penelitian ini bertujuan untuk mengetahui nilai aktivitas antioksidan daun matoa, daun sirsak, dan kombinasi keduanya dengan berbagai pelarut yaitu etanol 96%, etil asetat, dan air. Ekstrak daun matoa dan daun sirsak dibuat dengan metode maserasi selama 3x24 jam, menggunakan pelarut etanol 96%. Setelah diperoleh ekstrak kental, difraksinasi dengan aquades dan etil asetat diulangi sebanyak 3x, pembuatan ekstrak kombinasi digunakan perbandingan 1:1. Uji aktivitas antioksidan dengan metode DPPH menggunakan spektrofotometri UV-Visibel. Lalu dilakukan skrining fitokimia menggunakan senyawa fenolik, flavonoid, triterpenoid, saponin, dan tanin. Hasil skrining fitokimia menunjukkan ekstrak daun matoa dan daun sirsak positif mengandung fenolik, flavonoid, dan tanin. Hasil penelitian ini mendapatkan nilai IC50 dari ekstrak etanol daun matoa sebesar 5,46 ppm yang dikategorikan sangat kuat sedangkan ekstrak etil asetat daun sirsak 5,40 ppm yang juga di kategorikan sangat kuat. Kombinasi kedua ekstrak memiliki nilai  IC50 4,39 ppm lebih kuat daripada ekstrak tunggal. Menunjukan kombinasi daun matoa dan daun sirsak berpotensi menjadi agen antioksidan alami. Kata kunci : antioksidan, matoa (Pometia pinnata), sirsak (Annona muricata L.),  kombinasi, DPPH, IC50, fitokimia.
PENINGKATAN KESADARAN MASYARAKAT TERHADAP PRODUK HALAL DAN THAYYIB Himmi Marsiati; Anna P. Roswiem; Triayu Septiani; Dedy Suseno
Jurnal Pengabdian Masyarakat Multidisiplin Vol 6 No 1 (2022): Oktober
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jpm.v6i1.2655

Abstract

Halal products generally can be seen from the Halal Certificate and or Halal Label on the product packaging. However, halal products often are sold with products that have not been guaranteed to the Halal in one place of display such as in supermarkets or the market, so it can’t be known the halalness of the product. To know halal and thayyib products, knowledge of foodstuffs are classified as halal and thayyib is needed. The purpose of this Community Service (PKM) activity is to socialize and educate related halal and thayyib products, the ingredients used in the product manufacturing process, and the halal critical point of each ingredient and or product. This form of activity is in the form of education and socialization about halal and thayyib materials and or products that enter, circulate, and be traded in the territory of Indonesia. To see the success rate and satisfaction of participants in this PKM activity are done through pretest, posttest, and questionnaire. The result of this PKM is that the participants can understand that the products that enter, circulate, and are traded in the territory of Indonesia are syubhat, so they must be halal certified. In addition, the participants of the PKM program can know and or distinguish what ingredients or products are halal or haram, as well as which are thayyib and which are not thayyib.
Molecular Biomarkers in Pneumonia: Therapeutic Potential of Traditional Plant Medicine Tirsa Persila Awairaro; Diniwati Mukhtar; Dicky Budiman; Himmi Marsiati
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.6671

Abstract

Pneumonia causes 2.56 million global deaths annually, with current therapies limited by antimicrobial resistance and adverse effects. Traditional medicinal plants offer multi-target potential through anti-inflammatory, antioxidant, and immunomodulatory mechanisms. This review synthesizes knowledge on molecular biomarkers in pneumonia pathogenesis and evaluates therapeutic potential of medicinal plants, particularly Coleus amboinicus. A comprehensive literature search was conducted across PubMed/MEDLINE, Scopus, and Web of Science covering publications from January 2000 to June 2025. Inclusion criteria encompassed studies investigating molecular biomarkers, pneumonia therapeutic pathways, or medicinal plants with respiratory therapeutic properties. Narrative synthesis was employed due to study heterogeneity. Of 1,247 articles identified, 10 studies met inclusion criteria and were utilized in the analysis. Key inflammatory biomarkers included IL-6, TNF-α, and IL-1β, increasing from 5.05 mg/dL (controls) to 25.30 mg/dL in bacterial pneumonia. Neutrophil extracellular trap (NET) formation emerged as a central mechanism (47.36% of protein targets). Coleus amboinicus demonstrated 139 bioactive compounds with broad-spectrum antimicrobial activity and antioxidant properties (DPPH EC₅₀ 32.67-152.8 µg/mL). Traditional medicinal plants, particularly Coleus amboinicus, modulate key molecular pathways in pneumonia through sophisticated multi-target mechanisms, supporting integration of biomarker-guided approaches in contemporary respiratory care.
Co-Authors Anna P. Roswiem Carolin Aprilia Baslani Dicky Budiman Diniwati Mukhtar Hasna Luthfiah Karina A Ridwan Muhammad Andre Niljon Q Qomariyah Sri Wuryanti Suseno, Dedy Tirsa Persila Awairaro Triayu Septiani