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All Journal Homeostasis: Jurnal Mahasiswa Pendidikan Dokter
Sasongko Hadi Priyono
Universitas Lambung Mangkurat
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health

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Perbedaan Aktivitas SGPT Sebelum dan Sesudah Kemoterapi Neoadjuvan Penderita Ca Mammae Stadium Lanjut Lokal Subtipe Luminal Murti Fatiya Filayati; FX Hendriyono; Sasongko Hadi Priyono
Homeostasis Vol 3, No 3 (2020)
Publisher : Homeostasis

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Abstract

Abstract: Neoadjuvant chemotherapy is given 3-4 cycles before surgery for locally advanced breast cancer. Aimed at reducing tumour size, killing micrometastases. The purpose was to determine differences in SGPT activity before the first cycle and third cycle of neoadjuvant chemotherapy in patients locally advanced breast cancer luminal subtypes. The research was analytic observational, retrospective cohort method. Sampling with a total sampling technique, data analysis using a paired t-test. Results obtained 18 samples inclusion criteria with median SGPT activity before first cycle of neoadjuvant chemotherapy 13.5U/L with lowest value of 6 U/L highest value of 51 U/L, median SGPT activity before third cycle of neoadjuvant chemotherapy 17.5 U/L lowest value of 9 U/L highest value of 50 U/L. There was a significant difference (p=0.044) SGPT activity before the first cycle and third cycle of neoadjuvant chemotherapy in patients locally advanced breast cancer luminal subtypes in Ulin Hospital Banjarmasin in January-June 2019 period. Keywords: locally advanced breast cáncer, luminal subtype, neoadjuvant chemotherapy, SGPT activity. Abstrak: Kemoterapi neoadjuvan dilakukan sebelum operasi sebanyak 3-4 siklus untuk ca mammae lanjut lokal. Bertujuan memperkecil ukuran tumor dan membunuh mikrometastasis. Tujuan penelitian untuk mengetahui apakah terdapat perbedaan aktivitas SGPT sebelum siklus pertama dan siklus ketiga kemoterapi neoadjuvan pada penderita ca mammae stadium lanjut lokal subtipe luminal. Penelitian bersifat observasional analitik dengan metode Kohort Retrospektif. Penganbilan sampel dengan teknik total sampling dan analisis data menggunakan uji t berpasangan. Hasil penelitian didapatkan 18 sampel yang memenuhi kriteria inklusi dengan median aktivitas SGPT sebelum siklus pertama kemoterapi neoadjuvan 13,5U/L dengan nilai terendah 6 U/L nilai tertinggi 51 U/L, median aktivitas SGPT sebelum siklus ketiga kemoterapi neoadjuvan 17,5 U/L dengan nilai terendah 9 U/L nilai tertinggi 50 U/L. Terdapat perbedaan bermakna (p = 0,044) aktivitas SGPT sebelum siklus pertama dan siklus ketiga kemoterapi neoadjuvan pada penderita ca mammae stadium lanjut lokal subtipe luminal di RSUD Ulin Banjarmasin periode Januari - Juni 2019. Kata-kata kunci:  ca mammae lanjut lokal subtipe luminal, kemoterapi neoadjuvan, aktivitas SGPT
Perbedaan Jumlah Trombosit sebelum dan sesudah Kemoterapi Neoadjuvan pada Pasien Kanker Payudara Lathifah Laila Ulfa; FX Hendriyono; Sasongko Hadi Priyono
Homeostasis Vol 3, No 1 (2020)
Publisher : Homeostasis

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Abstract

Abstrack: There are two approaches to treating locally advanced luminal subtypes of  breast cancer, that is by providing neoadjuvant chemotherapy and surgery. One of the effects of chemotherapy is myelosuppression. Myelosuppression will reduce production of blood cells both erythrocytes, leukocytes, and platelets. This study aims to determine the differences number of platelets before first cycle and third cycle of neoadjuvant chemotherapy in patients with locally advanced with luminal subtypes breast cancer at Ulin Hospital Banjarmasin January-June 2019 Period. Samples were taken by total sampling technique. Data analysis using a paired T-test. There were 17 subjects with locally advanced with luminal subtypes breast cancer who met the exclusion and inclusion criteria. The mean of  platelet count before first cycle was 311,706 / uL and before third cycle was 377,764 / uL. Paired T-test results p = 0.008 which showed differences from platelet counts before first cycle and thrid cycle neoadjuvant chemotherapy. Keywords: locally advanced subtypes luminal of breast cancer , chemotherapy neoadjuvant, platelets. Abstrak: Terdapat dua pendekatan untuk mengobati kanker payudara yang berada pada stadium lanjut lokal yaitu memberikan kemoterapi neoadjuvan serta pembedahan. Salah satu efek dari kemoterapi adalah mielosupresi. Mielosupresi akan menurunkan produksi sel darah baik itu eritrosit, leukosit dan trombosit.  Penelitian ini bertujuan untuk mengetahui apakah terdapat perbedaan jumlah trombosit sebelum siklus pertama dan siklus ketiga kemoterapi neoadjuvan pada pasien kanker payudara yang terdiagnosis stadium lanjut lokal subtipe luminal di RSUD Ulin Banjarmasin Januari-Juni 2019. Sampel diambil dengan teknik total sampling. Data dianalisis menggunakan uji T berpasangan. Didapatakan sebanyak 17 subjek yang memenuhi kriteria eksklusi dan inklusi. Hasil rerata jumlah trombosit sebelum siklus pertama sebesar 311.706/uL dan siklus ketiga sebesar 377.764/uL. Hasil uji T berpasangan didapatkan p =  0,008 yang berarti bahwa terdapat perbedaan bermakna dari jumlah trombosit sebelum siklus pertama dan siklus ketiga kemoterapi neoadjuvan. Kata-kata kunci: kanker payudara lanjut lokal subtipe luminal, kemoterapi neoadjuvan, trombosit.
Co-Authors FX Hendriyono FX Hendriyono Lathifah Laila Ulfa Murti Fatiya Filayati