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All Journal Jurnal Respirologi Indonesia
Oea Khairsyaf
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Andalas
Health Professions Medicine & Pharmacology

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Association Between D-Dimer Level with Clinical Severity and Radiological Imaging of Confirmed COVID-19 Patients at RSUP Dr. M. Djamil Padang Hafis Herdiman; Masrul Basyar; Oea Khairsyaf
Jurnal Respirologi Indonesia Vol 42, No 4 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v42i4.241

Abstract

Background: D-dimer could be used as a biomarker to distinguish the severity of COVID-19. High D-Dimer levels are associated with increased clinical severity and poor radiological imaging. This study aims to identify the correlation between D-dimer levels with clinical severity and radiological features of confirmed COVID-19 patients at RSUP dr. M. Djamil Padang.Methods: This was a cross sectional study of 202 COVID-19 confirmed patients at RSUP dr. M. Djamil Padang using medical record data from 1 January to 31 March 2021. The data were collected using convenience sampling technique and analyzed by Kruskal Wallis Test to determine the association between D-dimer levels with clinical severity and radiological features.Results: Majority of patients were in age groups of below 50 and 50-59 years, with equal proportion between men and women, and were in moderate clinical severity (58,4%). Most radiological imaging was in severe degree of 91 patients (45%). The association between D-dimer levels and clinical degree of COVID-19 patients as well as the association between D-dimer levels and severity of radiological imaging of COVID-19 patients were statistically significant (P=0.0001).Conclusion: Elevated D-dimer level was a common feature at COVID-19 confirmed patients. High levels of D-dimer were associated with increased clinical severity and severe radiological features in COVID-19 patients.
Risk Factors Associated with 28-Day Mortality of COVID-19 Patients at RSUP Dr. M. Djamil Padang Lusi Agustini Arda; Oea Khairsyaf; Russilawati Russilawati; Tuti Handayani
Jurnal Respirologi Indonesia Vol 43, No 1 (2023)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v43i1.238

Abstract

Background: The COVID-19 mortality rate varies widely around the world. The COVID-19 death rate in Indonesia is currently relatively higher than the world average and is the highest in Southeast Asia. Data regarding risk factors of COVID-19 mortality in Indonesia, particularly West Sumatra, are still scarce. This study aims to determine the risk factors associated with the 28-day mortality of COVID-19 patients at RSUP Dr. M. Djamil Padang.Methods: This was an observational analytic study with a retrospective cohort approach on confirmed COVID-19 inpatients who were treated at RSUP Dr. M. Djamil Padang between January 1 and March 31, 2021. A bivariate analysis using Chi square was calculated to see the correlation between clinical severity, and routine blood values, markers of inflammation, liver function, kidney function, blood gas analysis, the RALE score and comorbidities with a 28-day mortality outcome. To assess the dominant risk factors, multivariate analysis was performed using logistic regression.Results: From 245 samples, patients aged >50 years and women were the most treated group of patients. Bivariate analysis obtained the following critical clinical grade factors: Hb <10 g/dl, leukocyte level >10.0x103/mm3, monocyte level 8.0%, procalcitonin level >0.5 ng/ml, interleukin-6 level >7 pg/ml, ferritin >159/ml, D-Dimer level >500 ng/dl, SGOT level >38 μ/l, urea >50 mg/dl, creatinine >1.3 mg/dl, PO2 <80 mmHg, SO2 ≤90%, PO2/FiO2 ≤300 mmHg, high RALE score, comorbid of chronic renal failure, hypertension, type II DM; and comorbidities >1 were associated with 28 days of death. Multivariate analysis identified critical clinical severity as the dominant risk factor (OR=8.47; 95% CI=2.55–28.14; P<0.001).Conclusion: Critical clinical severity was the dominant risk factor associated with the 28-day mortality of COVID-19 patients at RSUP Dr. M. Djamil.
Association Between Ferritin Levels and Sepsis in Patients with COVID-19 at Dr. M. Djamil Hospital Diana Nur Asrini; Oea Khairsyaf; Afriani Afriani
Jurnal Respirologi Indonesia Vol 44, No 1 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i1.545

Abstract

Background: Ferritin is an important mediator of immunomodulatory dysregulation and pro-inflammatory effects, which contribute to cytokine storms that could lead to sepsis in a critically ill patients with COVID-19. The role of ferritin as a biomarker of sepsis in those patients is yet fully understood. The aim of this study is to investigate an association between ferritin levels and sepsis in patients with COVID-19.Method: This study was a retrospective, cross-sectional study of 474 COVID-19 hospitalized patients at Dr. M. Djamil Hospital, Padang.Result: Most of the COVID-19 patients in this study were between the ages of 18 and 49 (38,61%), female (55.91%), with moderate clinical illness (40.50%), and had one comorbidity (41,14%) with obesity as the most common comorbidity (37.97%). More than half of patients (54,22%) had ferritin levels of ≥500 ng/mL (median 1,201 ng/mL with a range of 503–12,010 ng/mL). The incidence of sepsis was significantly higher in the group whose ferritin level was ≥ 500 ng/ml compared to those with less ferritin level (P<0.001; OR=3.33; 5.99% vs 17.91%; CI 95%=1.74-6.36).Conclusion: There is a statistically significant association between the ferritin level and sepsis in patiens with COVID-19 at DR M Djamil Hospital.
Co-Authors Afriani Afriani Diana Nur Asrini Hafis Herdiman Lusi Agustini Arda Masrul Basyar Russilawati, Russilawati Tuti Handayani