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All Journal Buletin Ilmiah Nagari Membangun Majalah Kedokteran Andalas
Siti Aisyah
Andalas University
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Pengaruh Pemberian Ekstrak Buah Pohon Andalas (Morus macraura Miq.) Terhadap Ekspresi Gen ET-1 Pada Tikus Model Aterosklerosis Dio Kurniawan; Intan Putri Syamtoni; Tio Firmansyah; Siti Aisyah; Hirowati Ali
Majalah Kedokteran Andalas Vol 45, No 4 (2022): Online October 2022
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v45.i4.p575-582.2022

Abstract

Tujuan: mengetahui respon antiinflamasi dari pemberian ekstrak buah pohon andalas (Morus macroura Miq.) terhadap gen ET-1 dan penebalan tunika intima tikus model ateroskerosis. Metode: uji eksperimental. Hewan coba dibagi dalam 6 kelompok, dengan 3 kelompok kontrol dan 3 kelompok perlakuan. Kelompok kontrol negatif tanpa perlakuan, kelompok kontrol positif dengan ligasi arteri karotis dan diet tinggi lemak, kelompok kontrol K hanya dengan ligasi arteri. Untuk semua kelompok perlakuan dilakukan ligasi arteri karotis, pemberian diet tinggi lemak, dan pemberian ekstrak buah pohon andalas 1 ml dengan dosis yang berbeda (100mg/kgBB, 300 mg/kgBB, dan 500 mg/kgBB). Pemberian diet tinggi lemak dilakukan selama 1 minggu. Ekstrak buah andalas diberikan secara oral selama 15 hari. Analisis kuantitatif kadar gen ET-1 dilakukan dengan menggunakan qPCR sedangkan untuk mengetahui respon terhadap penumpukan plak aterosklerosis dilakukan dengan cara pemeriksaan histopatologi. Hasil: Adanya hubungan yang signifikan antara pemberian ekstrak buah pohon andalas terhadap ekspresi gen ET-1 dengan nilai 0,02 (P<0,05) dan adanya pengaruh terhadap penebelan tunika intima tikus aterosklerosis yang dibuktikan dengan gambaran histologi arteri karotis tikus yang menujukkan pengurangan plak aterosklerosis. Kesimpulan: pemberian ekstrak buah pohon andalas dengan dosis 300mg/kgBB berpengaruh paling baik terhadap ekspresi gen ET-1 dan penebalan tunika intima tikus yang diinduksi aterosklerosis. 
EDUKASI KESEHATAN TENTANG INFEKSI SOIL TRANSMITTED-HELMINTHS DENGAN MEDIA BOARD GAME DI SD IT AL MARHAMAH KAMPUNG DALAM KABUPATEN PADANG PARIAMAN Selfi Renita Rusjdi; Refa Rahmaddiansyah; Muhammad Nur Alif Johar; Mutia Utami; gabriel septian hendra; Maisarah Fadhilah; Wulandari Wulandari; Ahmad Raffi Yustian; Siti Aisyah; Nilam Faizah Kaltsum; Selin Faysa Satiya
BULETIN ILMIAH NAGARI MEMBANGUN Vol. 7 No. 1 (2024)
Publisher : LPPM (Institute for Research and Community Services) Universitas Andalas Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/bina.v7i1.580

Abstract

Worm infections caused by soil-transmitted helminths (STH) occur almost throughout the world, especially in countries with tropical climates. In terms of prevalence, Indonesia ranks third in cases of worm infections, the majority of which infect school-aged children in coastal areas. This activity was carried out for students at SD IT Al Marhamah Kampung Dalam in Padang Pariaman Regency by providing education about preventing soil-transmitted helminth (STH) infections using board game media. The activity aims to increase students' knowledge regarding soil transmitted helminth infections and their prevention. This activity uses a descriptive observational approach, with the target covering students in grades 3 to 6 at SD IT Al Marhamah. The activity was carried out on February 11, 2023, at SD IT Al Marhamah Padang Pariaman with board game media to educate school children about worm infections. Activities consist of licensing, implementation of service, and evaluation. In total, 94 SD IT Al Marhamah Padang Pariaman students participated in service activities. In terms of distribution, there were 39 men and 55 women. Before the extension activities, a pretest was carried out. Then, education was carried out and continued with a post-test to assess students' knowledge of STH infections. The research results showed that there was an increase in the level of knowledge before and after the intervention. It was concluded that the final results of the activity showed that the increase in the level of knowledge of SD IT Al Marhamah students regarding soil transmitted helminth infections after being given counseling using the board game method showed that the intervention was successful. The students who took part in the activity were satisfied with the extension activity and gave a positive response.
Co-Authors Ahmad Raffi Yustian Dio Kurniawan gabriel septian hendra Hirowati Ali Intan Putri Syamtoni Maisarah Fadhilah Muhammad Nur Alif Johar Mutia Utami Nilam Faizah Kaltsum Refa Rahmaddiansyah Selfi Renita Rusjdi Selin Faysa Satiya Tio Firmansyah Wulandari Wulandari