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All Journal Jurnal Penelitian Sekolah Tinggi Ilmu Kesehatan Nahdlatul Ulama Tuban Jurnal Kesehatan Tambusai Jurnal Penelitian
Alfian Abdul Rajab
STIKES Banyuwangi
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EFEKTIFITAS EKSTRAK ETANOL DAUN SIRSAK (Annona Muricata L.) TERHADAP KADAR GLUKOSA DARAH TIKUS PUTIH (Rattus norvegicus) YANG DIINDUKSI ALOKSAN Ainun Najib; Leny Eka Tyas Wahyuni; Adieba Warda Hayya; Alfian Abdul Rajab
Jurnal Penelitian Vol 4, No 2 (2022): JURNAL PENELITIAN
Publisher : Institut Ilmu Kesehatan Nahdlatul Ulama Tuban

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47710/jp.v4i2.181

Abstract

Soursop leaves (Annona muricata L.) contain flavonoid compounds. Flavonoid compounds act as diabetes drugs. This study aimed to determine the effect of soursop leaf ethanol extract on alloxan-induced hypoglycemia in white male rats. In this study, four treatment groups were used, namely. negative control received no treatment, positive control received treatment with metformin 9 mg, the first treatment 7.2 mg and the last group was treated with a second dose of 14.4 mg. Rats were satisfied first before being treated, then measured blood sugar levels were. Rats were induced with alloxan intraperitoneally (IP), then observed the development of their blood sugar levels for three days, and their blood sugar levels were checked once a day. For seven days, then given ethanol extract of Soursop leaves daily for five days. The results showed that soursop leaf ethanol extract could reduce blood glucose on days H4-H8, which decreased by 6.67 mg / mL in the treatment group 1 sample and 5.66 mg / mL in the treatment sample.2. The test results with the Kruskal-Wallis test at the level of 0.05 showed that there was no significant difference between the use of soursop leaf ethanol extract and metformin against blood sugar reduction.
EFEKTIFITAS EKSTRAK ETANOL DAUN SIRSAK (Annona Muricata L.) TERHADAP KADAR GLUKOSA DARAH TIKUS PUTIH (Rattus norvegicus) YANG DIINDUKSI ALOKSAN Ainun Najib; Leny Eka Tyas Wahyuni; Adieba Warda Hayya; Alfian Abdul Rajab
Jurnal Penelitian Sekolah Tinggi Ilmu Kesehatan Nahdlatul Ulama Tuban Vol. 4 No. 2 (2022): JURNAL PENELITIAN
Publisher : Institut Ilmu Kesehatan Nahdlatul Ulama Tuban

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (40.246 KB) | DOI: 10.47710/jp.v4i2.181

Abstract

Soursop leaves (Annona muricata L.) contain flavonoid compounds. Flavonoid compounds act as diabetes drugs. This study aimed to determine the effect of soursop leaf ethanol extract on alloxan-induced hypoglycemia in white male rats. In this study, four treatment groups were used, namely. negative control received no treatment, positive control received treatment with metformin 9 mg, the first treatment 7.2 mg and the last group was treated with a second dose of 14.4 mg. Rats were satisfied first before being treated, then measured blood sugar levels were. Rats were induced with alloxan intraperitoneally (IP), then observed the development of their blood sugar levels for three days, and their blood sugar levels were checked once a day. For seven days, then given ethanol extract of Soursop leaves daily for five days. The results showed that soursop leaf ethanol extract could reduce blood glucose on days H4-H8, which decreased by 6.67 mg / mL in the treatment group 1 sample and 5.66 mg / mL in the treatment sample.2. The test results with the Kruskal-Wallis test at the level of 0.05 showed that there was no significant difference between the use of soursop leaf ethanol extract and metformin against blood sugar reduction.
INTERVENSI TERAPI GIZI PASIEN DIABETES MELLITUS TIPE 2 DENGAN SEPSIS, GANGRENE DAN ANEMIA Rajab, Alfian Abdul
Jurnal Kesehatan Tambusai Vol. 6 No. 2 (2025): JUNI 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v6i2.45152

Abstract

Diabetes mellitus tipe 2 merupakan permasalahan dimana terjadinya resistensi insulin didalam tubuh yang menyebabkan terjadinya peningkatan kadar glukosa darah. Sepsis dan gangrene merupakan komplikasi yang dijumpai pada pasien DMT2 yang disebabkan karena adanya inflamasi dan infeksi. Terapai gizi diperlukan guna untuk mencegah komplikasi pada pasien dan mempercepat proses kesembuahan pasien. Penelitian ini adalah studi kasus dengan pendekatan observasional deskriptif, dimana melakukan observasi pada pasien dengan diagnosa diabetes mellitus tipe 2 dengan komplikasi. Tn. A, 54 tahun merupakan pasien diabetes mellitus tipe 2 dengan komplikasi  sepsis, gangren pedis dextra, ulkus pedis sinistra dan anemia. penelitian ini yaitu diketahui status gizi pasien berdasarkan % LLA adalah 72,8% (Gizi Kurang). Pemeriksaan data biokimia yaitu 2 JPP 134 mg/dL dan gula darah puasa yaitu 117 mg/dL dalam batas normal. Perkembangan fisik pasien yaitu keadaan umum pada hari pertama sampai akhir pasien tetap merasa lemah. Tekanan darah, nadi dan suhu tubuh pasien selama intervensi selalu dalam keadaan normal. RR pasien normal, hari ketiga dan ke empat normal. Evaluasi rata-rata asupan makan pasien selama intervensi gizi sebesar Energi 1340,3 kkal (75%), Protein  78,8 gram (89%), Lemak 43,8 gram (109,5%) Karbohidrat 239,8 gram (90%) dan Fe 12,51 mg (96%) menunjukkan terjadikan peningkatan asupan gizi selama 4 hari. Pemberian terapi gizi yang adekuat dapat membantu perbaikan kondisi pasien diabetes mellitus dengan komplikasi.
Co-Authors Adieba Warda Hayya Ainun Najib Hapzi Ali Leny Eka Tyas Wahyuni