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All Journal Jurnal Ilmiah Farmako Bahari
Meigita Indah Farkhani
Universitas Padjadjaran
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology

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CASPASE IN PEPTIC ULCER Meigita Indah Farkhani; Jutti Levita
Jurnal Ilmiah Farmako Bahari Vol 13, No 2 (2022): Jurnal Ilmiah Farmako Bahari
Publisher : Fakultas MIPA Universitas Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jfb.v13i2.1266

Abstract

Peptic ulcer disease (PUD) is when gastric mucosa gets injured due to the increase of gastric acid and the pepsin enzyme. The common risk factors are the infection of Helicobacter pylori bacteria and the misused of NSAIDs. This review article aims to describe the role of caspase in PUD. Methods used are the selection of articles in PubMed. Caspase is a protease enzyme that plays an apoptotic and inflammatory reaction that can be activated when dimerized or cleaved. Caspase-3, caspase-6, caspase-7, caspase-8, and caspase-9 are divided into two subgroups for the apoptotic group. Caspase-1, caspase 4, and caspase-5 are part of inflammation group. Some compounds can inhibit modulateit. Moreover, most of them work for being inhibitors to avoid PUD. Caspase-1 holds a high responsibility to activate other caspases.
Co-Authors Jutti Levita