Obesity, a global health challenge influenced by genetic and environmental factors, is characterized by excessive body fat that increases the risk of various diseases. With over two billion individuals affected worldwide, addressing this issue is crucial. This study investigated the application of Artificial Intelligence (AI) to predict obesity status using a dataset of 1,610 individuals, including demographic and anthropometric data. Four AI algorithms were analyzed: Artificial Neural Network (ANN), K-Nearest Neighbors (KNN), Random Forest, and Support Vector Machine (SVM). The Synthetic Minority Over-Sampling Technique (SMOTE) was applied to address dataset imbalance. The results demonstrate that SMOTE significantly enhanced the models' performance, especially in recall and F1-score for minority classes, such as obesity. Random Forest achieved the highest accuracy (92%) and recall (92%) post-SMOTE. The ANN showed substantial improvement in recall, increasing from 77% to 89%, whereas the SVM achieved the highest precision (89%), minimizing false positives. Despite these improvements, KNN remained the least effective. The findings underscore the critical role of SMOTE in improving AI model accuracy for obesity prediction and highlight Random Forest as the most reliable algorithm for clinical decision-making. Limitations, such as dataset representativeness, suggest future research directions, including expanding data diversity and advanced feature selection techniques. This study provides valuable insights into leveraging AI and preprocessing methods for obesity management.