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All Journal Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Jurnal Riset Kefarmasian Indonesia Jurnal Ilmiah Medicamento
Saleh Wikarsa, Saleh
School of Pharmacy, Institute of Technology of Bandung, Indonesia
Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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PENGERINGAN EKSTRAK KELOPAK BUNGA ROSELA (Hibiscus sabdariffa L.) MELALUI MIKROENKAPSULASI DENGAN MALTODEKSTRIN METODE SEMPROT KERING Nining, Nining; Seowandhi, Sundani Nurono; Wikarsa, Saleh
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol 4 No 2 (2017)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (821.954 KB) | DOI: 10.22236/farmasains.v4i2.234

Abstract

Rosela (Hibiscus sabdariffa L.) memiliki banyak aktivitas farmakologi yang telah banyak dilaporkan baik secara in vitro maupun in vivo dan telah banyak diuji secara klinis. Penggunaan ekstrak dalam bentuk serbuk akan lebih praktis dan lebih terukur pemakaiannya sebagai bahan baku farmasi serta memudahkan dalam penyimpanan, pendistribusian, standardisasi zat aktif dan dapat meningkatkan stabilitasnya. Tujuan penelitian ini adalah mempelajari efek penambahan maltodekstrin terhadap karakteristik fisik serbuk ekstrak kelopak bunga rosela dengan pembentukan mikrokapsul metode semprot kering. Penelitian dilakukan dengan menyiapkan larutan umpan dalam rasio 1:1 (R1); 1:2 (R2); dan 1:4 (R3) dengan kandungan total padatan 10%. Kemudian dilakukan mikroenkapsulasi  metode semprot kering pada suhu inlet 110-115°C, outlet 99-104°C, dan laju alir 200 mL/jam. Mikrokapsul diperoleh dengan struktur morfologi seperti bola. Rata-rata ukuran partikel menurun seiring dengan penambahan maltodekstrin. Penambahan maltodekstrin dapat menurunkan sifat higroskopisitas ekstrak serta meningkatkan kelarutan dalam air dan susut pengeringan. Proses semprot kering serbuk R2 mimiliki nilai efisiensi enkapsulasi 97,73% dan perolehan kembali produk 74,05%. Semua serbuk mikrokapsul memberikan nilai sisa pelarut < 1%.
FORMULASI NANOEMULGEL EKSTRAK KULIT MANGGIS (Garcinia Mangostana L.) Damayanti, Hilda; Wikarsa, Saleh; Jafar, Garnadi
Jurnal Riset Kefarmasian Indonesia Vol 1 No 3 (2019): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (830.298 KB) | DOI: 10.33759/jrki.v1i3.53

Abstract

Antioxidant-containing cosmetic has antiaging therapy that can inhibit the free radical formation. Mangosteen peel extract has very strong antioxidant activity. To enhance the effect and comfortness of mangosteen peel extract use on the skin, it could be made into nanoemulgel. The article provides the information about method of preparation and evaluation of nanoemulsion-gel. The purpose of this study was to formulate a stable microemulgel of mangosteen peel extractusing halal materials declared halal according to Islamic Shari’a. the materials used don’t contain carrion, blood, pig and/ animals that don’t conform to Islamic Shari’a. Microemulgel mangosteen peel extract was made by varying plantacare® 1200 UP concentration as cosurfactant (5, 10, 15, 20 and 25%) in the microemulsion and it was incorporated into the gel base. Evaluations were included the antioxidant activity test and organoleptic, pH, viscosity, stability, particle size analysis and panelist test. The antioxidant activity determined by DPPH method showed that IC50 value of mangosteen peel extract was 5.54 ppm. The third microemulsion formula containing cosurfactant of 15% resulted in the best results in that the parameter of the product can be penetrated by ray laser was at particle size of 23.65 nm, was determined by tranmission Electron Microscopy (TEM). Microemulgel containing Viscolam® MAC 10 of seven percent gave the stable formula proofed by freeze thaw and sentrifuga test. The five microemulgel formulations were stable.
Kombinasi Teknik Pembentukan Kokristal dan Ball milling untuk Peningkatan Disolusi Etoricoxib Susanto, Sharon; Wikarsa, Saleh; Nugraha, Yuda Prasetya
Jurnal Ilmiah Medicamento Vol 10 No 1 (2024): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v10i1.7561

Abstract

Etoricoxib (ETX) is a selective COX-2 anti-inflammatory drug classified in BCS class II. This study aims to enhance the dissolution rate of etoricoxib through a combination of co-crystal formation and ball milling conducted in-situ and ex-situ. Optimization was done by varying milling times and types of stabilizers, including Tween 80 (ETX-OXA-BM-T), Poloxamer 188 (ETX-OXA-BM-P), and a combination of Tween 80-sodium lauryl sulfate (SLS) (ETX-OXA-BM-T-S). In-situ experiments yielded a very low yield (<10%) and failed to produce co-crystals, thus deeming them unsuitable for continuation. Meanwhile, the ex-situ process showed more potential, leading to further evaluation using Differential Scanning Calorimetry (DSC), Powder X-Ray Diffractometry (PXRD), and Scanning Electron Microscope (SEM). DSC analysis showed endothermic peaks at 130°C for ETX and around 179 - 180°C for ETX-OXA and its derivatives. PXRD diffractograms for ETX-OXA and its derivatives exhibited similar peaks, differing from ETX. SEM analysis indicated that ETX-OXA-BM-T with 60 minutes of milling resulted in nanometer-sized particles, while the use of Poloxamer 188 and the combination of Tween 80-SLS produced particle sizes > 1 µm. ETX-OXA-BM-T showed the highest increase in solubility in all media. The dissolution results of ETX-OXA-BM-T showed improvement in phosphate buffer pH 6.8, while no significant differences were observed in pH 1.2 and 4.5 buffers. This study demonstrates that the combination of co-crystal formation and ex-situ ball milling is a potential approach to enhancing the dissolution rate of etoricoxib.
Co-Authors Damayanti, Hilda Garnadi Jafar, Garnadi Nining, Nining Nugraha, Yuda Prasetya Seowandhi, Sundani Nurono Susanto, Sharon