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All Journal CARADDE: Jurnal Pengabdian Kepada Masyarakat JFL : Jurnal Farmasi Lampung Jurnal Ilmiah Medicamento Prima Abdika: Jurnal Pengabdian Masyarakat SITAWA : Jurnal Farmasi Sains dan Obat Tradisional Amal Ilmiah: Jurnal Pengabdian Kepada Masyarakat
Susanto, Sharon
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Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Public Health Social Sciences Other

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Kombinasi Teknik Pembentukan Kokristal dan Ball milling untuk Peningkatan Disolusi Etoricoxib Susanto, Sharon; Wikarsa, Saleh; Nugraha, Yuda Prasetya
Jurnal Ilmiah Medicamento Vol 10 No 1 (2024): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v10i1.7561

Abstract

Etoricoxib (ETX) is a selective COX-2 anti-inflammatory drug classified in BCS class II. This study aims to enhance the dissolution rate of etoricoxib through a combination of co-crystal formation and ball milling conducted in-situ and ex-situ. Optimization was done by varying milling times and types of stabilizers, including Tween 80 (ETX-OXA-BM-T), Poloxamer 188 (ETX-OXA-BM-P), and a combination of Tween 80-sodium lauryl sulfate (SLS) (ETX-OXA-BM-T-S). In-situ experiments yielded a very low yield (<10%) and failed to produce co-crystals, thus deeming them unsuitable for continuation. Meanwhile, the ex-situ process showed more potential, leading to further evaluation using Differential Scanning Calorimetry (DSC), Powder X-Ray Diffractometry (PXRD), and Scanning Electron Microscope (SEM). DSC analysis showed endothermic peaks at 130°C for ETX and around 179 - 180°C for ETX-OXA and its derivatives. PXRD diffractograms for ETX-OXA and its derivatives exhibited similar peaks, differing from ETX. SEM analysis indicated that ETX-OXA-BM-T with 60 minutes of milling resulted in nanometer-sized particles, while the use of Poloxamer 188 and the combination of Tween 80-SLS produced particle sizes > 1 µm. ETX-OXA-BM-T showed the highest increase in solubility in all media. The dissolution results of ETX-OXA-BM-T showed improvement in phosphate buffer pH 6.8, while no significant differences were observed in pH 1.2 and 4.5 buffers. This study demonstrates that the combination of co-crystal formation and ex-situ ball milling is a potential approach to enhancing the dissolution rate of etoricoxib.
AKTIVITAS ANTIBAKTERI DARI FRAKSI DAUN KATUK HUTAN (Breynia cernua) ASAL PAPUA: ANTIBACTERIAL ACTIVITY OF FRACTION KATUK HUTAN LEAF (Breynia cernua) FROM PAPUA Ishariyanto, Riski; Dirgantara, Septriyanto; Susanto, Sharon; Septiana, Rita
JFL : Jurnal Farmasi Lampung Vol. 14 No. 1 (2025): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v14i1.2489

Abstract

Abstract Katuk hutan leaf (Breynia cernua) are endemic plants of Papua traditionally used to treat cancer, smallpox and wounds. It contains various bioactive compounds such as alkaloids, flavonoids, terpenoids and tannins. Fractionation using n-hexane, ethyl acetate and ethanol-water solvents was performed to isolate specific bioactive components. This study aims to evaluate the antibacterial activity of n-hexane fraction, ethyl acetate fraction and ethanol-water fraction of Breynia cernua leaf against Staphylococcus aureus and Escherichia coli. Antibacterial testing was conducted using the disc diffusion method at concentrations of 250, 500 and 750 ppm. All fractions exhibited inhibition zones in the moderate to strong category against both bacteria. The highest antibacterial activity was observed in the n-hexane fraction at 750 ppm with inhibition zone of 10.2 ± 0.8 mm for S. aureus and 10.3 ± 0.8 mm for E. coli. ANOVA analysis showed a significant difference (p < 0.05) between the n-hexane fraction and the other fractions. These results indicate that the n-hexane fraction of Breynia cernua leaves has the most potent antibacterial effect. Keywords:  Breynia cernua, disc diffusion, inhibition zone, Staphylococcus aureus, Escherichia coli.
Edukasi Kesehatan tentang Penggunaan Antibiotik secara Bijak pada Masyarakat Car Free Day Jakarta Christian, Yulius Evan; Gunawan, Untung; Laurensia; Chaineyla, Florencia; Alwi, Felisca Emmalyn; Susanto, Sharon
CARADDE: Jurnal Pengabdian Kepada Masyarakat Vol. 8 No. 1 (2025): Agustus
Publisher : Ilin Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31960/caradde.v8i1.3050

Abstract

The misuse of antibiotics remains a public health concern and contributes to the risk of antimicrobial resistance. To raise public awareness and knowledge about appropriate antibiotic use, an educational activity was conducted during the Car Free Day event in the Sudirman area of Jakarta. The education was delivered through direct counseling using leaflet media to participants aged 15 years and above. A total of 38 individuals took part in the activity and completed questionnaires before and after the session. The results showed an increase in the average knowledge score from 51.7 to 71.4. Statistical analysis using a paired t-test indicated a significant difference (p < 0.05), suggesting that the education had a positive impact on participants’ understanding. Furthermore, it was found that some members of the public still consume antibiotics without a doctor’s prescription. This activity demonstrates that public-space educational approaches can serve as a strategic effort to improve community understanding of rational antibiotic use.
Pengenalan Simbol dalam Kemasan Obat pada Masyarakat di Area Car Free Day Jakarta Susanto, Sharon; Christian, Yulius Evan; Susanto, Michael Darell; Putri, Fadhilla Sivana; Nababan, Agnes Aditia; Gunawan, Untung
Prima Abdika: Jurnal Pengabdian Masyarakat Vol. 5 No. 2 (2025): Volume 5 Nomor 2 Tahun 2025 (Juni)
Publisher : Program Studi Pendidikan Guru Sekolah Dasar Universitas Flores Ende

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37478/abdika.v5i2.5598

Abstract

Symbols on drug packaging are vital for providing essential information regarding the usage, dosage, and safety warnings of medications. A lack of understanding of these symbols may lead to improper use of drugs, posing potential health risks. This community service initiative aimed to increase public awareness of these symbols through socialization activities targeted at the visitors of Car Free Day (CFD) Jakarta, a popular public gathering space with diverse individuals. The objective of this initiative was to evaluate the level of public understanding before and after the socialization of the symbols on drug packaging. A total of 60 participants were engaged in identifying the symbols on drug packaging, followed by an educational session explaining the meanings of these symbols. Data was collected using questionnaires and analyzed to determine whether there was a notable improvement in participants' understanding. The results indicated a significant increase in public knowledge following the educational intervention. The findings suggest that socialization efforts on the understanding of packaging symbols can enhance public awareness, potentially leading to safer and more informed medication use. It is recommended that similar socialization activities be conducted in other areas with high foot traffic to expand the reach of this educational effort.
Optimization Of Bilberry Extract (Vaccinium myrtillus L.) Micellar Water Formulation With Humectant Variation Using The Simplex Lattice Design (Sld) Method Susanto, Sharon
SITAWA : Jurnal Farmasi Sains dan Obat Tradisional Vol. 5 No. 1 (2026): SITAWA : Jurnal Farmasi Sains dan Obat Tradisional
Publisher : LPPM Akademi Farmasi Imam Bonjol Bukittinggi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62018/sitawa.v5i1.196

Abstract

Micellar water is a water-based cosmetic formulation designed to cleanse the face effectively without the need for rinsing. This study aimed to develop and optimize a micellar water formulation containing bilberry (Vaccinium myrtillus L.) extract—known for its antioxidant properties—combined with humectants glycerin and propylene glycol. The optimization process was carried out using the Simplex Lattice Design (SLD) method. Phytochemical screening of the bilberry extract confirmed the presence of active secondary metabolites including flavonoids, polyphenols, tannins, triterpenoids, and saponins. Five formulations were evaluated based on organoleptic properties, pH, viscosity, foam height, and foam stability. All formulations met standard cosmetic specifications. SLD analysis indicated that variations in humectant concentration only statistically significant effect (p < 0.05) on the foam height parameter. The optimal formula was identified with a combination of 9.75% propylene glycol and 5.25% glycerin, achieving a desirability value of 1.000. In conclusion, this formulation shows great potential as a natural, effective, and skin-friendly micellar water product.
Edukasi dan Praktik Parfum Aman sebagai Strategi Preventif Risiko Iritasi Kulit pada Remaja Wulandari, Erna; Christian , Yulius Evan; Susanto, Sharon; Setiawan, Patrycia; Tanoto, Madeline Keke
Amal Ilmiah: Jurnal Pengabdian Kepada Masyarakat Vol. 7 No. 1 (2026): Edisi Maret 2026
Publisher : FKIP Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36709/amalilmiah.v7i1.788

Abstract

Penggunaan parfum di kalangan remaja semakin meningkat, namun belum diimbangi dengan pemahaman yang memadai mengenai keamanan bahan dan potensi risiko kesehatan. Banyak siswa memilih parfum berdasarkan aroma dan harga tanpa memperhatikan komposisi bahan serta aspek keamanan produk, sehingga berpotensi menimbulkan gangguan kesehatan kulit dan saluran pernapasan. Kegiatan pengabdian kepada masyarakat ini bertujuan meningkatkan pengetahuan dan kesadaran siswa SMA mengenai penggunaan parfum yang aman serta melatih keterampilan pembuatan parfum sederhana dengan bahan yang lebih aman. Metode kegiatan meliputi pre-test, penyampaian materi edukasi, praktik pembuatan parfum, dan post-test sebagai evaluasi. Kegiatan diikuti oleh 39 siswa SMA. Hasil kegiatan menunjukkan peningkatan pengetahuan peserta yang ditandai dengan kenaikan nilai rata-rata dari 60,26 pada pre-test menjadi 75,13 pada post-test. Uji statistik menggunakan software analisis menunjukkan data homogen (p = 0,071) dan tidak berdistribusi normal (p < 0,05), sehingga dilakukan uji Wilcoxon yang menunjukkan perbedaan bermakna antara nilai sebelum dan sesudah kegiatan (p < 0,05). Kegiatan edukasi dan praktik terbukti efektif dalam meningkatkan literasi kesehatan siswa mengenai keamanan penggunaan parfum. Oleh karena itu, peningkatan literasi bahan kimia kosmetik pada remaja menjadi hal yang mendesak sebagai upaya preventif untuk meminimalkan risiko kesehatan akibat penggunaan produk kosmetik yang tidak aman sejak usia sekolah.
Pelatihan Spray Anti Nyamuk Berbahan Alami sebagai Solusi Ramah Lingkungan untuk Pengendalian Nyamuk Aedes aegypti Susanto, Sharon; Christian, Yulius Evan; Wijardi , Calista; Nathali, Nathali; Susanto , Jessica Mutiara; Agustine , Grace Nathania
CARADDE: Jurnal Pengabdian Kepada Masyarakat Vol. 8 No. 3 (2026): April
Publisher : Ilin Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31960/caradde.v8i3.3259

Abstract

Dengue Hemorrhagic Fever (DHF) remains a public health concern, particularly in densely populated urban communities. The prolonged use of chemical-based insecticides poses health and environmental risks, necessitating the adoption of safer, natural alternatives. This community service program aimed to enhance public knowledge and skills through education and training on the formulation of mosquito repellent spray using lemongrass and lavender. The methods included interactive lectures, group discussions, and hands-on workshops. Evaluation was conducted using a pre-test and post-test consisting of 10 multiple-choice questions. Results showed a significant increase in the average score from 78.3 to 88.67. The median score improved from 80 to 90, while the minimum and maximum scores remained constant (60 and 100, respectively). These findings indicate that the practical-based learning approach effectively increased participants’ understanding of the risks of chemical insecticides and the benefits of natural repellents. Additionally, participants demonstrated high enthusiasm and interest in reproducing the herbal spray independently. This program not only improved environmental health literacy but also opened opportunities for household-scale entrepreneurship using eco-friendly products. Similar activities are recommended for replication in other areas, with further development and cross-sector collaboration.
Co-Authors Agustine , Grace Nathania Alwi, Felisca Emmalyn Chaineyla, Florencia Christian , Yulius Evan Gunawan, Untung Ishariyanto, Riski Laurensia Nababan, Agnes Aditia Nathali, Nathali Nugraha, Yuda Prasetya Putri, Fadhilla Sivana Saleh Wikarsa, Saleh Septiana, Rita Setiawan, Patrycia Susanto , Jessica Mutiara Susanto, Michael Darell Tanoto, Madeline Keke Wijardi , Calista Wulandari, Erna Yulius Evan Christian