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All Journal Jurnal Perkotaan CARADDE: Jurnal Pengabdian Kepada Masyarakat JFL : Jurnal Farmasi Lampung Amalee: Indonesian Journal of Community Research & Engagement Jurnal Ilmiah Medicamento Medfarm: Jurnal Farmasi dan Kesehatan Prima Abdika: Jurnal Pengabdian Masyarakat
Susanto, Sharon
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Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Public Health Social Sciences Other

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Kombinasi Teknik Pembentukan Kokristal dan Ball milling untuk Peningkatan Disolusi Etoricoxib Susanto, Sharon; Wikarsa, Saleh; Nugraha, Yuda Prasetya
Jurnal Ilmiah Medicamento Vol 10 No 1 (2024): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v10i1.7561

Abstract

Etoricoxib (ETX) is a selective COX-2 anti-inflammatory drug classified in BCS class II. This study aims to enhance the dissolution rate of etoricoxib through a combination of co-crystal formation and ball milling conducted in-situ and ex-situ. Optimization was done by varying milling times and types of stabilizers, including Tween 80 (ETX-OXA-BM-T), Poloxamer 188 (ETX-OXA-BM-P), and a combination of Tween 80-sodium lauryl sulfate (SLS) (ETX-OXA-BM-T-S). In-situ experiments yielded a very low yield (<10%) and failed to produce co-crystals, thus deeming them unsuitable for continuation. Meanwhile, the ex-situ process showed more potential, leading to further evaluation using Differential Scanning Calorimetry (DSC), Powder X-Ray Diffractometry (PXRD), and Scanning Electron Microscope (SEM). DSC analysis showed endothermic peaks at 130°C for ETX and around 179 - 180°C for ETX-OXA and its derivatives. PXRD diffractograms for ETX-OXA and its derivatives exhibited similar peaks, differing from ETX. SEM analysis indicated that ETX-OXA-BM-T with 60 minutes of milling resulted in nanometer-sized particles, while the use of Poloxamer 188 and the combination of Tween 80-SLS produced particle sizes > 1 µm. ETX-OXA-BM-T showed the highest increase in solubility in all media. The dissolution results of ETX-OXA-BM-T showed improvement in phosphate buffer pH 6.8, while no significant differences were observed in pH 1.2 and 4.5 buffers. This study demonstrates that the combination of co-crystal formation and ex-situ ball milling is a potential approach to enhancing the dissolution rate of etoricoxib.
AKTIVITAS ANTIBAKTERI DARI FRAKSI DAUN KATUK HUTAN (Breynia cernua) ASAL PAPUA: ANTIBACTERIAL ACTIVITY OF FRACTION KATUK HUTAN LEAF (Breynia cernua) FROM PAPUA Ishariyanto, Riski; Dirgantara, Septriyanto; Susanto, Sharon; Septiana, Rita
JFL : Jurnal Farmasi Lampung Vol. 14 No. 1 (2025): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v14i1.2489

Abstract

Abstract Katuk hutan leaf (Breynia cernua) are endemic plants of Papua traditionally used to treat cancer, smallpox and wounds. It contains various bioactive compounds such as alkaloids, flavonoids, terpenoids and tannins. Fractionation using n-hexane, ethyl acetate and ethanol-water solvents was performed to isolate specific bioactive components. This study aims to evaluate the antibacterial activity of n-hexane fraction, ethyl acetate fraction and ethanol-water fraction of Breynia cernua leaf against Staphylococcus aureus and Escherichia coli. Antibacterial testing was conducted using the disc diffusion method at concentrations of 250, 500 and 750 ppm. All fractions exhibited inhibition zones in the moderate to strong category against both bacteria. The highest antibacterial activity was observed in the n-hexane fraction at 750 ppm with inhibition zone of 10.2 ± 0.8 mm for S. aureus and 10.3 ± 0.8 mm for E. coli. ANOVA analysis showed a significant difference (p < 0.05) between the n-hexane fraction and the other fractions. These results indicate that the n-hexane fraction of Breynia cernua leaves has the most potent antibacterial effect. Keywords:  Breynia cernua, disc diffusion, inhibition zone, Staphylococcus aureus, Escherichia coli.
Edukasi Kesehatan tentang Penggunaan Antibiotik secara Bijak pada Masyarakat Car Free Day Jakarta Christian, Yulius Evan; Gunawan, Untung; Laurensia; Chaineyla, Florencia; Alwi, Felisca Emmalyn; Susanto, Sharon
CARADDE: Jurnal Pengabdian Kepada Masyarakat Vol. 8 No. 1 (2025): Agustus
Publisher : Ilin Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31960/caradde.v8i1.3050

Abstract

The misuse of antibiotics remains a public health concern and contributes to the risk of antimicrobial resistance. To raise public awareness and knowledge about appropriate antibiotic use, an educational activity was conducted during the Car Free Day event in the Sudirman area of Jakarta. The education was delivered through direct counseling using leaflet media to participants aged 15 years and above. A total of 38 individuals took part in the activity and completed questionnaires before and after the session. The results showed an increase in the average knowledge score from 51.7 to 71.4. Statistical analysis using a paired t-test indicated a significant difference (p < 0.05), suggesting that the education had a positive impact on participants’ understanding. Furthermore, it was found that some members of the public still consume antibiotics without a doctor’s prescription. This activity demonstrates that public-space educational approaches can serve as a strategic effort to improve community understanding of rational antibiotic use.
Pengenalan Simbol dalam Kemasan Obat pada Masyarakat di Area Car Free Day Jakarta Susanto, Sharon; Christian, Yulius Evan; Susanto, Michael Darell; Putri, Fadhilla Sivana; Nababan, Agnes Aditia; Gunawan, Untung
Prima Abdika: Jurnal Pengabdian Masyarakat Vol. 5 No. 2 (2025): Volume 5 Nomor 2 Tahun 2025 (Juni)
Publisher : Program Studi Pendidikan Guru Sekolah Dasar Universitas Flores Ende

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37478/abdika.v5i2.5598

Abstract

Symbols on drug packaging are vital for providing essential information regarding the usage, dosage, and safety warnings of medications. A lack of understanding of these symbols may lead to improper use of drugs, posing potential health risks. This community service initiative aimed to increase public awareness of these symbols through socialization activities targeted at the visitors of Car Free Day (CFD) Jakarta, a popular public gathering space with diverse individuals. The objective of this initiative was to evaluate the level of public understanding before and after the socialization of the symbols on drug packaging. A total of 60 participants were engaged in identifying the symbols on drug packaging, followed by an educational session explaining the meanings of these symbols. Data was collected using questionnaires and analyzed to determine whether there was a notable improvement in participants' understanding. The results indicated a significant increase in public knowledge following the educational intervention. The findings suggest that socialization efforts on the understanding of packaging symbols can enhance public awareness, potentially leading to safer and more informed medication use. It is recommended that similar socialization activities be conducted in other areas with high foot traffic to expand the reach of this educational effort.
Integrating Sustainability into Cosmetic Manufacturing and Consumption: Challenges and Innovations Rachmawati, Putriana; Susanto, Sharon; Christian, Yulius Evan
Jurnal Perkotaan Vol. 17 No. 2 (2025): Edisi Desember 2025
Publisher : Universitas Katolik Indonesia Atma Jaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/perkotaan.v17i2.7353

Abstract

The global cosmetic industry continues to grow rapidly, with revenues projected to exceed USD 800 billion by 2030. However, the use of synthetic ingredients, plastic packaging, and energy- and water-intensive production processes has led to environmental impacts. This study examines the environmental impacts of the cosmetic industry through four key aspects: cosmetic ingredients, packaging, manufacturing processes, and consumer behavior. A literature review of publications from 2000 to 2025 obtained from major scientific databases was used. The results show that ingredients such as parabens, triclosan, and 1,4-dioxane contribute to pollution and environmental toxicity, while plastic packaging remains the main source of MPF. Sustainable alternatives, such as sugarcane straw extract, olive oil, whey protein isolate, and PLA-, cellulose-, and chitosan-based packaging materials, show strong potential to reduce environmental impact. Meanwhile, the adoption of renewable energy, waterloo systems, and recycling technologies in factories improves efficiency and reduces carbon emissions. Changes in consumer behavior, particularly among Generation Z, who are highly concerned about sustainability, also encourage producers to act more socially and environmentally responsibly. This study emphasizes the importance of implementing sustainable cosmetic practices to maintain a balance between industrial growth and environmental preservation.  
Nanococrystals in Pharmaceutical Development: Design, Characterization, and Applications Susanto, Sharon
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 2 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i2.663

Abstract

Drug solubility is a fundamental challenge in pharmaceutical development, especially for oral dosage forms where poor solubility limits therapeutic effectiveness. Among the approaches explored to address this issue, cocrystals and nanocrystals have shown notable advantages in improving physicochemical properties and drug delivery. Nanococrystals, which integrate the principles of both systems, represent a promising platform with potential benefits in solubility, bioavailability, and stability. This study was designed as a systematic literature review of publications from 2015 to 2025 retrieved from PubMed, Scopus, Web of Science, and ScienceDirect. Relevant studies were analyzed thematically to provide insights into nanococrystal design, including the role of active pharmaceutical ingredients, coformers, stabilizers, and solvents. Fabrication methods such as antisolvent precipitation, wet milling, high pressure homogenization, and spray flash evaporation were reviewed alongside characterization techniques including X-ray diffraction, thermal analysis, spectroscopy, and microscopy. Applications of nanococrystals consistently demonstrate significant improvements in solubility, dissolution rate, and oral bioavailability compared to conventional forms, confirming their potential as an advanced drug delivery strategy for future pharmaceutical development.
Community Education on Air Pollution–Related Skin Health Integrated with a Micellar Water Workshop in Jakarta Christian, Yulius Evan; Setiawan, Patrycia; Santoso, Vanessa Gracia; Gracia, Venestrata; Laurensia; Alwi, Felisca Emmalyn; Susanto, Sharon
Amalee: Indonesian Journal of Community Research and Engagement Vol. 7 No. 1 (2026): Amalee: Indonesian Journal of Community Research and Engagement
Publisher : LP2M INSURI Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37680/amalee.v7i1.8651

Abstract

Jakarta is one of the most polluted cities in Indonesia, which often exceeds safe health standards. Despite growing evidence linking air pollution to dermatological conditions, public knowledge and preventive behavior in urban communities remain limited and poorly addressed in community health programs. The objective of this program is to increase community knowledge about the effects of air pollution on skin health through a community-based education model that integrates pre-test and post-test assessments with practical activities. The program was conducted in three phases: pre-implementation, including material preparation and pretest-posttest assessment design; implementation, including a health education session and a practical workshop on micellar water formulation; and post-implementation, through evaluation and reporting. The activity was held on October 15, 2025, with 30 participants. Results showed a statistically significant improvement in participant knowledge, as measured by a paired t-test (p<0,05), with average scores increasing from 53.0 to 65.67. The assessment was conducted using a 10-question questionnaire before and after the activity. This activity highlights the potential of integrated educational and practical approaches to improve community understanding of environmental health risks and support the adoption of preventive self-care practices.
Co-Authors Alwi, Felisca Emmalyn Chaineyla, Florencia Gracia, Venestrata Gunawan, Untung Ishariyanto, Riski Laurensia Nababan, Agnes Aditia Nugraha, Yuda Prasetya Putri, Fadhilla Sivana rachmawati, Putriana Saleh Wikarsa, Saleh Santoso, Vanessa Gracia Septiana, Rita Setiawan, Patrycia Susanto, Michael Darell Yulius Evan Christian