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Kombinasi Teknik Pembentukan Kokristal dan Ball milling untuk Peningkatan Disolusi Etoricoxib Susanto, Sharon; Wikarsa, Saleh; Nugraha, Yuda Prasetya
Jurnal Ilmiah Medicamento Vol 10 No 1 (2024): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v10i1.7561

Abstract

Etoricoxib (ETX) is a selective COX-2 anti-inflammatory drug classified in BCS class II. This study aims to enhance the dissolution rate of etoricoxib through a combination of co-crystal formation and ball milling conducted in-situ and ex-situ. Optimization was done by varying milling times and types of stabilizers, including Tween 80 (ETX-OXA-BM-T), Poloxamer 188 (ETX-OXA-BM-P), and a combination of Tween 80-sodium lauryl sulfate (SLS) (ETX-OXA-BM-T-S). In-situ experiments yielded a very low yield (<10%) and failed to produce co-crystals, thus deeming them unsuitable for continuation. Meanwhile, the ex-situ process showed more potential, leading to further evaluation using Differential Scanning Calorimetry (DSC), Powder X-Ray Diffractometry (PXRD), and Scanning Electron Microscope (SEM). DSC analysis showed endothermic peaks at 130°C for ETX and around 179 - 180°C for ETX-OXA and its derivatives. PXRD diffractograms for ETX-OXA and its derivatives exhibited similar peaks, differing from ETX. SEM analysis indicated that ETX-OXA-BM-T with 60 minutes of milling resulted in nanometer-sized particles, while the use of Poloxamer 188 and the combination of Tween 80-SLS produced particle sizes > 1 µm. ETX-OXA-BM-T showed the highest increase in solubility in all media. The dissolution results of ETX-OXA-BM-T showed improvement in phosphate buffer pH 6.8, while no significant differences were observed in pH 1.2 and 4.5 buffers. This study demonstrates that the combination of co-crystal formation and ex-situ ball milling is a potential approach to enhancing the dissolution rate of etoricoxib.
Enhancing Adolescent Awareness on Safe Cosmetic Use: A Community Education at Santa Patricia High School, Tangerang Putriana Rachmawati; Nicky Nathanael; Jessica Christy Hamzah; Nathaniel Leslie; Sabrina Jovita Bunawan; Sharon Susanto; Yulius Evan Christian
Warta Pengabdian Andalas Vol 32 No 2 (2025)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.32.2.177-184.2025

Abstract

Cosmetics are products designed for use on the external parts of the human body to clean, alter appearance, provide fragrance, improve body odor, or maintain health. The cosmetic industry in Indonesia has experienced significant growth. Technology and beauty stereotypes disseminated through social media have influenced the increasing demand for cosmetics among teenagers. Research shows that 45.4% of teenagers in Indonesia use skincare products before the age of 19, and 46% experience skin health issues due to unsafe products. The Community Service Program aims to enhance teenagers' knowledge about safe cosmetics. This program was conducted through interactive lectures and a peel-off mask-making workshop at Santa Patricia High School in Tangerang, involving 72 students from 10th and 11th grades. Evaluation was performed through pretests and posttests, showing a 16% increase in participants' knowledge. A total of 82% of participants achieved good scores in the posttest. Additionally, 97% of participants understood the material presented, and 99% were satisfied with the overall event. This educational initiative successfully increased students' awareness and knowledge about the safety of cosmetic use, providing new insights into safe ingredients and steps for choosing appropriate cosmetics. Similar activities are encouraged to broaden teenagers' understanding of cosmetic safety.
AKTIVITAS ANTIBAKTERI DARI FRAKSI DAUN KATUK HUTAN (Breynia cernua) ASAL PAPUA: ANTIBACTERIAL ACTIVITY OF FRACTION KATUK HUTAN LEAF (Breynia cernua) FROM PAPUA Ishariyanto, Riski; Dirgantara, Septriyanto; Susanto, Sharon; Septiana, Rita
JFL : Jurnal Farmasi Lampung Vol. 14 No. 1 (2025): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v14i1.2489

Abstract

Abstract Katuk hutan leaf (Breynia cernua) are endemic plants of Papua traditionally used to treat cancer, smallpox and wounds. It contains various bioactive compounds such as alkaloids, flavonoids, terpenoids and tannins. Fractionation using n-hexane, ethyl acetate and ethanol-water solvents was performed to isolate specific bioactive components. This study aims to evaluate the antibacterial activity of n-hexane fraction, ethyl acetate fraction and ethanol-water fraction of Breynia cernua leaf against Staphylococcus aureus and Escherichia coli. Antibacterial testing was conducted using the disc diffusion method at concentrations of 250, 500 and 750 ppm. All fractions exhibited inhibition zones in the moderate to strong category against both bacteria. The highest antibacterial activity was observed in the n-hexane fraction at 750 ppm with inhibition zone of 10.2 ± 0.8 mm for S. aureus and 10.3 ± 0.8 mm for E. coli. ANOVA analysis showed a significant difference (p < 0.05) between the n-hexane fraction and the other fractions. These results indicate that the n-hexane fraction of Breynia cernua leaves has the most potent antibacterial effect. Keywords:  Breynia cernua, disc diffusion, inhibition zone, Staphylococcus aureus, Escherichia coli.
Edukasi Pengelolaan Obat Melalui Kegiatan Car Free Day: Membangun Masyarakat Cerdas Obat Untung Gunawan; Yulius Evan Christian; Sharon Susanto; Rafael Putra Nata Niel Sitorus; Shinta Amory; Jeremy Edward Thung
CARADDE: Jurnal Pengabdian Kepada Masyarakat Vol. 8 No. 1 (2025): Agustus
Publisher : Ilin Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31960/caradde.v8i1.3008

Abstract

Abstrak. Rendahnya literasi terhadap pengelolaan obat menjadi salah satu faktor utama tingginya praktik swamedikasi yang tidak tepat. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk meningkatkan pemahaman masyarakat mengenai pengelolaan obat yang benar, meliputi cara memperoleh, menggunakan, menyimpan, dan membuang obat secara bertanggung jawab. Kegiatan dilaksanakan di area Car Free Day Jakarta melalui metode ceramah, diskusi interaktif, pembagian , serta evaluasi melalui pretest dan postest. Sebanyak 81 peserta mengikuti kegiatan ini dengan latar belakang usia dan pendidikan yang bervariasi. Hasil evaluasi menunjukkan peningkatan pada seluruh indikator secara keseluruhan, peningkatan rata-rata skor pre test dari 53,95% menjadi 85,93% saat post test dan uji statistik menggunakan paired T-test menunjukkan hasil signifikan dengan nilai p < 0,05. Kesimpulan dari kegiatan ini bahwa edukasi langsung yang dilakukan di ruang publik efektif dalam meningkatkan pengetahuan masyarakat terkait pengelolaan obat, serta dapat direplikasi pada kegiatan sejenis di lingkungan komunitas lain untuk mendukung perilaku penggunaan obat yang lebih aman dan rasional.
Edukasi Kesehatan tentang Penggunaan Antibiotik secara Bijak pada Masyarakat Car Free Day Jakarta Christian, Yulius Evan; Gunawan, Untung; Laurensia; Chaineyla, Florencia; Alwi, Felisca Emmalyn; Susanto, Sharon
CARADDE: Jurnal Pengabdian Kepada Masyarakat Vol. 8 No. 1 (2025): Agustus
Publisher : Ilin Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31960/caradde.v8i1.3050

Abstract

The misuse of antibiotics remains a public health concern and contributes to the risk of antimicrobial resistance. To raise public awareness and knowledge about appropriate antibiotic use, an educational activity was conducted during the Car Free Day event in the Sudirman area of Jakarta. The education was delivered through direct counseling using leaflet media to participants aged 15 years and above. A total of 38 individuals took part in the activity and completed questionnaires before and after the session. The results showed an increase in the average knowledge score from 51.7 to 71.4. Statistical analysis using a paired t-test indicated a significant difference (p < 0.05), suggesting that the education had a positive impact on participants’ understanding. Furthermore, it was found that some members of the public still consume antibiotics without a doctor’s prescription. This activity demonstrates that public-space educational approaches can serve as a strategic effort to improve community understanding of rational antibiotic use.
Pengenalan Simbol dalam Kemasan Obat pada Masyarakat di Area Car Free Day Jakarta Susanto, Sharon; Christian, Yulius Evan; Susanto, Michael Darell; Putri, Fadhilla Sivana; Nababan, Agnes Aditia; Gunawan, Untung
Prima Abdika: Jurnal Pengabdian Masyarakat Vol. 5 No. 2 (2025): Volume 5 Nomor 2 Tahun 2025 (Juni)
Publisher : Program Studi Pendidikan Guru Sekolah Dasar Universitas Flores Ende

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37478/abdika.v5i2.5598

Abstract

Symbols on drug packaging are vital for providing essential information regarding the usage, dosage, and safety warnings of medications. A lack of understanding of these symbols may lead to improper use of drugs, posing potential health risks. This community service initiative aimed to increase public awareness of these symbols through socialization activities targeted at the visitors of Car Free Day (CFD) Jakarta, a popular public gathering space with diverse individuals. The objective of this initiative was to evaluate the level of public understanding before and after the socialization of the symbols on drug packaging. A total of 60 participants were engaged in identifying the symbols on drug packaging, followed by an educational session explaining the meanings of these symbols. Data was collected using questionnaires and analyzed to determine whether there was a notable improvement in participants' understanding. The results indicated a significant increase in public knowledge following the educational intervention. The findings suggest that socialization efforts on the understanding of packaging symbols can enhance public awareness, potentially leading to safer and more informed medication use. It is recommended that similar socialization activities be conducted in other areas with high foot traffic to expand the reach of this educational effort.
Edukasi dan Praktik Parfum Aman sebagai Strategi Preventif Risiko Iritasi Kulit pada Remaja Wulandari, Erna; Christian , Yulius Evan; Susanto, Sharon; Setiawan, Patrycia; Tanoto, Madeline Keke
Amal Ilmiah: Jurnal Pengabdian Kepada Masyarakat Vol. 7 No. 1 (2026): Edisi Maret 2026
Publisher : FKIP Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36709/amalilmiah.v7i1.788

Abstract

Penggunaan parfum di kalangan remaja semakin meningkat, namun belum diimbangi dengan pemahaman yang memadai mengenai keamanan bahan dan potensi risiko kesehatan. Banyak siswa memilih parfum berdasarkan aroma dan harga tanpa memperhatikan komposisi bahan serta aspek keamanan produk, sehingga berpotensi menimbulkan gangguan kesehatan kulit dan saluran pernapasan. Kegiatan pengabdian kepada masyarakat ini bertujuan meningkatkan pengetahuan dan kesadaran siswa SMA mengenai penggunaan parfum yang aman serta melatih keterampilan pembuatan parfum sederhana dengan bahan yang lebih aman. Metode kegiatan meliputi pre-test, penyampaian materi edukasi, praktik pembuatan parfum, dan post-test sebagai evaluasi. Kegiatan diikuti oleh 39 siswa SMA. Hasil kegiatan menunjukkan peningkatan pengetahuan peserta yang ditandai dengan kenaikan nilai rata-rata dari 60,26 pada pre-test menjadi 75,13 pada post-test. Uji statistik menggunakan software analisis menunjukkan data homogen (p = 0,071) dan tidak berdistribusi normal (p < 0,05), sehingga dilakukan uji Wilcoxon yang menunjukkan perbedaan bermakna antara nilai sebelum dan sesudah kegiatan (p < 0,05). Kegiatan edukasi dan praktik terbukti efektif dalam meningkatkan literasi kesehatan siswa mengenai keamanan penggunaan parfum. Oleh karena itu, peningkatan literasi bahan kimia kosmetik pada remaja menjadi hal yang mendesak sebagai upaya preventif untuk meminimalkan risiko kesehatan akibat penggunaan produk kosmetik yang tidak aman sejak usia sekolah.
Pelatihan Spray Anti Nyamuk Berbahan Alami sebagai Solusi Ramah Lingkungan untuk Pengendalian Nyamuk Aedes aegypti Susanto, Sharon; Christian, Yulius Evan; Wijardi , Calista; Nathali, Nathali; Susanto , Jessica Mutiara; Agustine , Grace Nathania
CARADDE: Jurnal Pengabdian Kepada Masyarakat Vol. 8 No. 3 (2026): April
Publisher : Ilin Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31960/caradde.v8i3.3259

Abstract

Dengue Hemorrhagic Fever (DHF) remains a public health concern, particularly in densely populated urban communities. The prolonged use of chemical-based insecticides poses health and environmental risks, necessitating the adoption of safer, natural alternatives. This community service program aimed to enhance public knowledge and skills through education and training on the formulation of mosquito repellent spray using lemongrass and lavender. The methods included interactive lectures, group discussions, and hands-on workshops. Evaluation was conducted using a pre-test and post-test consisting of 10 multiple-choice questions. Results showed a significant increase in the average score from 78.3 to 88.67. The median score improved from 80 to 90, while the minimum and maximum scores remained constant (60 and 100, respectively). These findings indicate that the practical-based learning approach effectively increased participants’ understanding of the risks of chemical insecticides and the benefits of natural repellents. Additionally, participants demonstrated high enthusiasm and interest in reproducing the herbal spray independently. This program not only improved environmental health literacy but also opened opportunities for household-scale entrepreneurship using eco-friendly products. Similar activities are recommended for replication in other areas, with further development and cross-sector collaboration.
Peningkatan Kesadaran Masyarakat terhadap Keselamatan Listrik demi Kesehatan dan Kesejahteraan Rumah Tangga Yulius Evan Christian; Hamdan Mustopa; Dini Permata Sari; Putriana Rachmawati; Sharon Susanto
Pharmacy Action Journal Vol 5, No 2 (2026): 2026
Publisher : UNIVERSITAS 17 AGUSTUS 1945 JAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/paj.v5i2.8972

Abstract

Leakage of electrical current is one of the leading causes of electrical accidents and household fires, particularly due to unsafe installations. Low awareness of this hazard, along with limited understanding of safety devices such as Earth Leakage Circuit Breakers (ELCB), prompted the implementation of a community service program in RW 04, Kalibaru Subdistrict, North Jakarta. Educational outreach, interactive discussions, and simulations of ELCB installation using a participatory educational approach were conducted through pre- and post-tests involving 34 participants. The results showed an increase in the average score from 40.30% in the pretest to 100% in the post-test. All indicators showed improvement, particularly in terms of understanding the PUIL, ELCB functions, emergency response to electric shock, and the importance of certified technicians. Statistical analysis revealed a significance value of p < 0.05, indicating a significant difference before and after the program. This activity has proven empirically effective in increasing community literacy on electrical safety and is recommended for replication in other areas with similar conditions.
Integrating Sustainability into Cosmetic Manufacturing and Consumption: Challenges and Innovations Putriana Rachmawati; Sharon Susanto; Yulius Evan Christian
Jurnal Perkotaan Vol. 17 No. 2 (2025): Desember 2025
Publisher : Universitas Katolik Indonesia Atma Jaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/perkotaan.v17i2.7353

Abstract

The global cosmetic industry continues to grow rapidly, with revenues projected to exceed USD 800 billion by 2030. However, the use of synthetic ingredients, plastic packaging, and energy- and water-intensive production processes has led to environmental impacts. This study examines the environmental impacts of the cosmetic industry through four key aspects: cosmetic ingredients, packaging, manufacturing processes, and consumer behavior. A literature review of publications from 2000 to 2025 obtained from major scientific databases was used. The results show that ingredients such as parabens, triclosan, and 1,4-dioxane contribute to pollution and environmental toxicity, while plastic packaging remains the main source of MPF. Sustainable alternatives, such as sugarcane straw extract, olive oil, whey protein isolate, and PLA-, cellulose-, and chitosan-based packaging materials, show strong potential to reduce environmental impact. Meanwhile, the adoption of renewable energy, waterloo systems, and recycling technologies in factories improves efficiency and reduces carbon emissions. Changes in consumer behavior, particularly among Generation Z, who are highly concerned about sustainability, also encourage producers to act more socially and environmentally responsibly. This study emphasizes the importance of implementing sustainable cosmetic practices to maintain a balance between industrial growth and environmental preservation.