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All Journal Biology, Medicine, & Natural Product Chemistry
Jesse Idakwoji
Madonna University
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health

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Inhibitory Effect of Mammea africana on Alpha-Amylase and Alpha-Glucosidase Enzymes of Rats Nwakaego Omonigho Ebong; Jude Efiom Okokon; Jesse Idakwoji
Biology, Medicine, & Natural Product Chemistry Vol 11, No 2 (2022)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2022.112.175-180

Abstract

Mammea africana Sabine (Guttiferae), a medicinal plant used traditionally in the treatment of diseases including diabetes was evaluated for effect on alpha-amylase and alpha-glucosidase enzymes in vivo. The stembark extract (30, 60 and 90 mg/kg) of M. africana were investigated in vivo for inhibitory effect on alpha-amylase and alpha-glucosidase enzymes using starch, sucrose and maltose as substrates. Acarbose was used as reference drug. The stembark extract caused significant (p<0.05) reduction in blood glucose levels of treated rats with the various substrates used. The results suggest that the stembark extract of M. africana have the potentials to inhibit alpha-amylase and alpha-glucosidase in rats.
Co-Authors Jude Efiom Okokon Nwakaego Omonigho Ebong