Biology, Medicine, & Natural Product Chemistry
Vol 11, No 2 (2022)

Inhibitory Effect of Mammea africana on Alpha-Amylase and Alpha-Glucosidase Enzymes of Rats

Nwakaego Omonigho Ebong (Madonna University)
Jude Efiom Okokon (University of Uyo)
Jesse Idakwoji (Madonna University)

Article Info

Publish Date
12 Sep 2022

Abstract

Mammea africana Sabine (Guttiferae), a medicinal plant used traditionally in the treatment of diseases including diabetes was evaluated for effect on alpha-amylase and alpha-glucosidase enzymes in vivo. The stembark extract (30, 60 and 90 mg/kg) of M. africana were investigated in vivo for inhibitory effect on alpha-amylase and alpha-glucosidase enzymes using starch, sucrose and maltose as substrates. Acarbose was used as reference drug. The stembark extract caused significant (p<0.05) reduction in blood glucose levels of treated rats with the various substrates used. The results suggest that the stembark extract of M. africana have the potentials to inhibit alpha-amylase and alpha-glucosidase in rats.

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Journal Info
Biology, Medicine, & Natural Product Chemistry
Website

Abbrev

BIOMEDICH

Publisher

Universitas Islam Negeri Sunan Kalijaga Yogyakarta

Subject

Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health

Description

BIOLOGY, MEDICINE, & NATURAL PRODUCT CHEMISTRY, this journal is published to attract and disseminate innovative and expert findings in the fields of plant, animal, and microorganism secondary metabolite, and also the effect of natural product on biological system as a reference source for ...