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All Journal Indonesian Journal of Science and Technology Pharmaceutical Reports
La Ode Muh. Julian Purnama
Thammasat University
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology

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Phytochemical Profile and Anticancer Activity from Medicinal Plants Against Melanoma Skin Cancer: A Review Adryan Fristiohady; Rathapon Asasutjarit; La Ode Muh. Julian Purnama; Sewan Theeramunkong; Wirhamsah Al-Ramadan; Lidya Agriningsih Haruna; Nur Syifa Rahmatika; Syarul Nataqain Baharum; I. Sahidin
Indonesian Journal of Science and Technology Vol 7, No 3 (2022): IJOST: VOLUME 7, ISSUE 3, December 2022
Publisher : Universitas Pendidikan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17509/ijost.v7i3.51325

Abstract

Melanoma skin cancer is a malignant melanocyte tumor considered the most invasive and dangerous skin cancer, with an average five-year survival rate of less than 5% after metastasis. Thus, a new strategy for preventing and treating cancer from the natural product is required. Medicinal plants are the potential as an alternative against cancer. This review article aims to determine natural products from medicinal plants which have the potential as an anticancer in melanoma skin cancer in vitro and in vivo. 40 plants have been selected based on the selection criteria for anticancer compounds. In vitro studies showed that the plant can reduce cell viability through cell cycle inhibition and apoptosis induction and inhibit angiogenesis, invasion, and metastasis in human melanoma skin cancer. Therefore, further research is required to explore more plants, especially medicinal plants, their active compounds, and the mechanism of anticancer action to be used as standard herbal medicines.
Anticancer Potential of Water Fraction of Cashew Leaf (Anacardium occidentale L.) on A-375 Melanoma Cell Line In Vitro Fitria Nurcahyani; Adryan Fristiohady; Wahyuni; Sahidin; Suryani; Irnawati; Jumriani; La Ode Muh. Julian Purnama
Pharmaceutical Reports Vol. 5 No. 2 (2026): (October) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/ke7ac573

Abstract

Melanoma is an aggressive form of skin cancer with a high potential for metastasis and resistance to conventional therapies, highlighting the need for safer and more effective treatment alternatives. Natural products, particularly plant-derived compounds, have gained attention as promising sources of anticancer agents. This study aimed to evaluate the anticancer potential of the aqueous fraction of cashew leaves (Anacardium occidentale L.) against melanoma in vitro. Anticancer activity was assessed through cytotoxicity and cell migration assays. Cytotoxic effects were determined using the MTT assay on A-375 melanoma cells, while selectivity was evaluated using normal HaCaT keratinocyte cells. Antimetastatic activity was examined using a scratch wound healing assay to determine the ability of the fraction to inhibit cancer cell migration. The results demonstrated that the aqueous fraction exhibited cytotoxic activity against melanoma cells, with an IC₅₀ value of 184.29 ± 3.16 µg/mL, and showed good selectivity toward normal cells (SI = 6.68). Furthermore, the fraction significantly inhibited melanoma cell migration after 24 hours of treatment, indicating potential antimetastatic activity. This effect may be attributed to the presence of flavonoid and phenolic compounds, which are known to induce apoptosis and reduce oxidative stress. In conclusion, the aqueous fraction of A. occidentale leaves shows promising potential as a natural anticancer agent and may serve as a candidate for adjunctive therapy in melanoma treatment. KEYWORDS: Anticancer; MTT cytotoxicity; cashew leaves; cell migration.
Co-Authors Adryan Fristiohady Adryan Fristiohady Fitria Nurcahyani Irnawati Jumriani Lidya Agriningsih Haruna Nur Syifa Rahmatika Rathapon Asasutjarit Sahidin Sahidin Sahidin Sewan Theeramunkong Suryani Syarul Nataqain Baharum Wahyuni Wirhamsah Al-Ramadan