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All Journal Indonesian Journal of Science and Technology Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology
Syarul Nataqain Baharum
Universiti Kebangsaan Malaysia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Environmental Science Immunology & microbiology

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Phytochemical Profile and Anticancer Activity from Medicinal Plants Against Melanoma Skin Cancer: A Review Adryan Fristiohady; Rathapon Asasutjarit; La Ode Muh. Julian Purnama; Sewan Theeramunkong; Wirhamsah Al-Ramadan; Lidya Agriningsih Haruna; Nur Syifa Rahmatika; Syarul Nataqain Baharum; I. Sahidin
Indonesian Journal of Science and Technology Vol 7, No 3 (2022): IJOST: VOLUME 7, ISSUE 3, December 2022
Publisher : Universitas Pendidikan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17509/ijost.v7i3.51325

Abstract

Melanoma skin cancer is a malignant melanocyte tumor considered the most invasive and dangerous skin cancer, with an average five-year survival rate of less than 5% after metastasis. Thus, a new strategy for preventing and treating cancer from the natural product is required. Medicinal plants are the potential as an alternative against cancer. This review article aims to determine natural products from medicinal plants which have the potential as an anticancer in melanoma skin cancer in vitro and in vivo. 40 plants have been selected based on the selection criteria for anticancer compounds. In vitro studies showed that the plant can reduce cell viability through cell cycle inhibition and apoptosis induction and inhibit angiogenesis, invasion, and metastasis in human melanoma skin cancer. Therefore, further research is required to explore more plants, especially medicinal plants, their active compounds, and the mechanism of anticancer action to be used as standard herbal medicines.
Effects of Derivatization on the Metabolite Profiling of the Cadmium-Tolerant Mangrove Fungus Trichoderma atroviride Using GC-MS Analysis Siti Athirah Mohamad Jamali; Kamalrul Azlan Azizan; Syarul Nataqain Baharum; Mariam Taib
Squalen, Buletin Pascapanen dan Bioteknologi Kelautan dan Perikanan Vol 17, No 3 (2022): December 2022
Publisher : Research and Development Center for Marine and Fisheries Product Processing and Biotechnol

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15578/squalen.714

Abstract

The mangrove fungus Trichoderma atroviride was found to be tolerant to the heavy metal cadmium and it is of high interest to profile its metabolites to gain insight into its response to cadmium toxicity. This study aimed to investigate the effect of derivatization agents on the number and types of metabolites present in the cadmium-tolerant T. atroviride, detected using GC-MS analysis. The intracellular and extracellular metabolites of T. atroviride treated with cadmium for ten days were derivatized using silylation and alkylation reactions. The results showed that a higher number of metabolites were identified when the three different derivatization agents were used: BSTFA, TBDMSTFA, and MCF. More types of metabolites were identified by silylation, making it suitable for non-targeted metabolites profiling study.  Silylation is efficient for the analysis of sugars and their derivatives while alkylation is suitable for a targeted study involving amino acids and organic acids. Statistical analysis for the data set of identified metabolites was performed using Metaboanalyst 3.0 followed by visualization using Partial Least Square-Discriminant Analysis. The plots showed clear separations of metabolites between the different types of derivatization agents and between control and cadmium-treated samples. A more comprehensive metabolite profile of T. atroviride obtained using different derivatization agents in this study, followed by distinct metabolites detected between control and treated samples, will provide good baseline information for future investigations including the pathways and biomarkers responsible for the fungal tolerance to cadmium toxicity.
Co-Authors Adryan Fristiohady I. Sahidin Kamalrul Azlan Azizan La Ode Muh. Julian Purnama Lidya Agriningsih Haruna Mariam Taib Nur Syifa Rahmatika Rathapon Asasutjarit Sewan Theeramunkong Siti Athirah Mohamad Jamali Wirhamsah Al-Ramadan