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All Journal Indonesian Journal of Science and Technology
Rathapon Asasutjarit
Thammasat University
Computer Science & IT Environmental Science

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Phytochemical Profile and Anticancer Activity from Medicinal Plants Against Melanoma Skin Cancer: A Review Adryan Fristiohady; Rathapon Asasutjarit; La Ode Muh. Julian Purnama; Sewan Theeramunkong; Wirhamsah Al-Ramadan; Lidya Agriningsih Haruna; Nur Syifa Rahmatika; Syarul Nataqain Baharum; I. Sahidin
Indonesian Journal of Science and Technology Vol 7, No 3 (2022): IJOST: VOLUME 7, ISSUE 3, December 2022
Publisher : Universitas Pendidikan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17509/ijost.v7i3.51325

Abstract

Melanoma skin cancer is a malignant melanocyte tumor considered the most invasive and dangerous skin cancer, with an average five-year survival rate of less than 5% after metastasis. Thus, a new strategy for preventing and treating cancer from the natural product is required. Medicinal plants are the potential as an alternative against cancer. This review article aims to determine natural products from medicinal plants which have the potential as an anticancer in melanoma skin cancer in vitro and in vivo. 40 plants have been selected based on the selection criteria for anticancer compounds. In vitro studies showed that the plant can reduce cell viability through cell cycle inhibition and apoptosis induction and inhibit angiogenesis, invasion, and metastasis in human melanoma skin cancer. Therefore, further research is required to explore more plants, especially medicinal plants, their active compounds, and the mechanism of anticancer action to be used as standard herbal medicines.
Phytochemical Profile and Biological Activities of Ethylacetate Extract of Peanut (Arachis hypogaea L.) Stems: In-Vitro and In-Silico Studies with Bibliometric Analysis Idin Sahidin; N. Nohong; Marianti A. Manggau; A. Arfan; W. Wahyuni; Iren Meylani; M. Hajrul Malaka; Nur Syifa Rahmatika; Agung W. M. Yodha; Nur Upik En Masrika; Abdulkadir Kamaluddin; Andini Sundowo; Sofa Fajriah; Rathapon Asasutjarit; Adryan Fristiohady; Rina Maryanti; Nur Indri Rahayu; M. Muktiarni
Indonesian Journal of Science and Technology Vol 8, No 2 (2023): (ONLINE FIRST) IJOST: September 2023
Publisher : Universitas Pendidikan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17509/ijost.v8i2.54822

Abstract

The utilization of the stems, leaves, and hulls of peanuts (Arachis hypogea) is not as popular as the seeds. This study aimed to investigate the chemical contents and pharmacological activities of A. hypogaea stems in-vitro and in-silico. This study was also completed with bibliometric analysis. The methanol extract (ME) was reextracted by ethylacetate to get ethyl acetate extract (EAE). The chemical contents of EAE were analyzed by phytochemical screening, Liquid Chromatography-Mass Spectroscopy (LC-MS/MS), TPC (Total Phenolic Content), and TFC (Total Flavonoid Content). In-vitro and in-silico studies evaluated antioxidant potency, toxicity, and cytotoxicity toward MCF-7 cell lines. The results showed that EAE contained terpenoids, flavonoids, alkaloids, and phenolics which were supported by LC-MS/MS data. The EAE was categorized as a very strong antioxidant and moderately active in both cytotoxicity and toxicity.
Co-Authors Abdulkadir Kamaluddin Adryan Fristiohady Adryan Fristiohady Agung W. M. Yodha Andini Sundowo Arfan Arfan I. Sahidin Idin Sahidin Iren Meylani La Ode Muh. Julian Purnama Lidya Agriningsih Haruna M. Hajrul Malaka Marianti A. Manggau Masrika, Nur Upik En Muktiarni, Muktiarni N. Nohong Nur Indri Rahayu Nur Syifa Rahmatika Nur Syifa Rahmatika Rina Maryanti Sewan Theeramunkong Sofa Fajriah Syarul Nataqain Baharum Wahyuni Wahyuni Wirhamsah Al-Ramadan