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All Journal The Indonesian Journal of Infectious Diseases Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Memy Aviatin
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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TERAPI FAVIPIRAVIR PADA SUBYEK COVID-19 DERAJAT SEDANG TANPA GANGGUAN LIVER DI RS PUSAT INFEKSI PROF DR SULIANTI SAROSO Hastutik Cairn Brisbane; Abdul Rahem; Anita Purnamayanti; Rosamarlina Rosamarlina; Memy Aviatin; Adria Rusli
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 2 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v7i2.880

Abstract

The outbreak of the corona virus which first contracted in December 2019 in Wuhan, China; Currently it has been designated by the World Health Organization (WHO) as a pandemic and is known as Corona Virus Infection Disease 2019 (Covid-19). This study aimed to describe the profile of favipiravir therapy in moderate COVID-19 inpatients without liver impairment at Prof. dr. Sulianti Saroso Infection Center Hospital. The design of this study was an observational study conducted retrospectively. All the patients in this research were received favipiravir loading dose of 1600 mg bid on the first day, and 600 mg bid starting on the day-2 of therapy. The results of the research were 81 moderate Covid-19 inpatients without history or recent liver impairment who were hospitalized in the period October 2020 - July 2021 dominating by female gender (56%). Mode of hospital admission were self-referral to Prof. dr. Sulianti Saroso Infection Center Hospital (83%), primary care (Puskesmas) referral (12%), and other hospital referral (5%). There were no comorbidity in 74,1% of the subjects. Among 25,9% subjects with comorbidity, most of the patients suffered from hypertension (29%); hypertension, and cardiovascular disease (17%). diabetes (12%); diabetes and hypertension (12%); Asthma (12). None of the subjects experienced increased in liver transaminases (ALT, AST), nor ALP and total bilirubin. Eighty-one patients were either cured (12%) with negative PCR test results or improved (88%) at the end of the therapy.
TERAPI FAVIPIRAVIR PADA SUBYEK COVID-19 DERAJAT SEDANG TANPA GANGGUAN LIVER DI RS PUSAT INFEKSI PROF DR SULIANTI SAROSO Hastutik Cairn Brisbane; Abdul Rahem; Anita Purnamayanti; Rosamarlina Rosamarlina; Memy Aviatin; Adria Rusli
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 2 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v7i2.880

Abstract

The outbreak of the corona virus which first contracted in December 2019 in Wuhan, China; Currently it has been designated by the World Health Organization (WHO) as a pandemic and is known as Corona Virus Infection Disease 2019 (Covid-19). This study aimed to describe the profile of favipiravir therapy in moderate COVID-19 inpatients without liver impairment at Prof. dr. Sulianti Saroso Infection Center Hospital. The design of this study was an observational study conducted retrospectively. All the patients in this research were received favipiravir loading dose of 1600 mg bid on the first day, and 600 mg bid starting on the day-2 of therapy. The results of the research were 81 moderate Covid-19 inpatients without history or recent liver impairment who were hospitalized in the period October 2020 - July 2021 dominating by female gender (56%). Mode of hospital admission were self-referral to Prof. dr. Sulianti Saroso Infection Center Hospital (83%), primary care (Puskesmas) referral (12%), and other hospital referral (5%). There were no comorbidity in 74,1% of the subjects. Among 25,9% subjects with comorbidity, most of the patients suffered from hypertension (29%); hypertension, and cardiovascular disease (17%). diabetes (12%); diabetes and hypertension (12%); Asthma (12). None of the subjects experienced increased in liver transaminases (ALT, AST), nor ALP and total bilirubin. Eighty-one patients were either cured (12%) with negative PCR test results or improved (88%) at the end of the therapy.
Pengaruh Penggunaan Antikoagulan Terhadap Penurunan Nilai D-Dimer pada Pasien COVID-19 Feri Setiadi; Dealya Adira Panjaitan; Memy Aviatin
The Indonesian Journal of Infectious Diseases Vol. 8 No. 2 (2022): The Indonesian Journal of Infectious Disease
Publisher : Rumah Sakit Penyakit Infeksi Prof Dr. Sulianti Saroso

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32667/ijid.v8i2.149

Abstract

Latar Belakang : COVID-19 diidentifikasi sebagai penyakit sistem pernapasan namun diketahui juga berperan dalam gangguan koagulasi darah. Peningkatan nilai D-dimer secara signifikan merupakan parameter koagulasi yang menandakan adanya hiperinflamasi dan menyebabkan terjadinya hiperkoagulasi. Tujuan : Untuk mengetahui pengaruh penggunaan antikoagulan berdasarkan jenis antikoagulan, rute, dan lama pemberian terhadap penurunan nilai D-dimer. Metode : Penelitian ini merupakan penelitian kuantitatif secara retrospektif dengan desain cross sectional dan menggunakan metode total sampling. Subjek penelitian sebanyak 246 pasien rawat inap COVID-19 di RSPI Prof. Dr. Sulianti Saroso periode Januari-Desember 2021. Hasil: Pemeriksaan D-dimer sebelum dan sesudah pemberian menunjukkan perbedaan signifikan (p<0,05) dimana rata-rata sebelum 1,477 mg/L dan sesudah 0,6806 mg/L dengan penurunan sebesar 0,778 mg/L. Hasil pengujian menunjukkan terdapat pengaruh dari variabel independen (penggunaan antikoagulan) terhadap variabel dependen (penurunan nilai D-dimer) (p<0,05) dimana variabel yang berpengaruh signifikan adalah jenis antikoagulan dan rute pemberian (p<0,05) serta diketahui bahwa jenis antikoagulan enoxaparin dan rute subkutan adalah yang paling baik dalam menurunkan nilai D-dimer. Kesimpulan: Dalam upaya mengatasi hiperkoagulasi pada pasien COVID-19, penggunaan antikoagulan dengan mempertimbangkan jenis dan rute pemberian akan memberikan pengaruh signifikan terhadap penurunan nilai D-dimer.
Co-Authors Abdul Rahem Adria Rusli Anita Purnamayanti Dealya Adira Panjaitan Feri Setiadi Hastutik Cairn Brisbane Rosamarlina Rosamarlina