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All Journal BIOEDUPAT: Pattimura Journal of Biology and Learning Rumphius Pattimura Biological Journal
Syahran Wael
Universitas Pattimura
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Immunology & microbiology

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Prevention of breast cancer with the breast self-examination method (BSE) in the Negeri Lima village, Leihitu District, Maluku Province Theopilus Wilhelmus Watuguly; Fredy Leiwakabessy; Johanis Fritzgal Rehena; Windi Mose; Syahran Wael
BIOEDUPAT: Pattimura Journal of Biology and Learning Vol 2 No 2 (2022): Bioedupat : Pattimura Journal of Biology and Learning
Publisher : Program Studi Pendidikan Biologi, Pascasarjana, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/bioedupat.v2.i2.pp32-36

Abstract

The number of incidences and deaths from cancer is increasing every year around the world. However, currently available cancer treatment methods still have weaknesses, the discovery of cancer drugs is still very important. The purpose of this study was to determine the effect of the level of public knowledge about breast cancer with BSE behavior on housewives in Negeri Lima Village, Maluku Province. The design of this research is descriptive analytic with a cross-sectional approach. The study was conducted in May 2022. The population in this study were residents of the village of Negeri Lima. Sampling using the method with 50 respondents. The tool used in this research is a questionnaire. The analysis technique used is Chi Square analysis. The results showed that the influence of the level of knowledge about breast cancer on housewives was mostly in the good category of 60.5%. BSE behavior in housewives is mostly in the category of not doing BSE by 40%. The results of the Chi Square analysis obtained the calculated X2 value of 55.40 with a p value of 0.000 (p <0.05). The close relationship between the level of knowledge of breast cancer with conscious behavior has a strong category indicated by a coefficient of 0.50. The conclusion of this study is that there is a relationship between the level of knowledge of mothers about breast cancer and the BSE behavior.
Inhibition of methanol extract snail gonggong (Strombus urturella) to pathogenic bacteria Vibrio alginolyticus Frans Selfanay; Syahran Wael; Theopilus Wilhelmus Watuguly
BIOEDUPAT: Pattimura Journal of Biology and Learning Vol 2 No 2 (2022): Bioedupat : Pattimura Journal of Biology and Learning
Publisher : Program Studi Pendidikan Biologi, Pascasarjana, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/bioedupat.v2.i2.pp58-64

Abstract

The purpose of this study was to determine the methanol extract of snail gonggong (Strombus turturella) and the inhibition of methanol extract of gonggong snail meat (Strombus turturella) against the pathogenic bacterium Vibrio alginolyticus. The study used a completely randomized design. The treatment was giving the extract of snail gonggong meat with concentration of 100%, 50%, 25%, positive control using amoxcillin and negative control using distilled water with three replications. The identification of bioactive compounds included alkaloids, saponins, flavonoids, steroids and triterpenoids. The antibacterial activity of the methanol extract of snail gonggong meat (Strombus turturella) was tested by the diffusion method at concentrations of 100%, 50% and 25%. The data collected is then analyzed descriptively qualitatively. The results showed that the antibacterial activity of the 100% concentration of the methanol extract of the gonggong snail meat had moderate inhibition against Vibrio alginolyticus (diameter 7,833 mm). while the concentrations of 50% and 25% did not have an inhibition zone. The identified bioactive compounds included alkaloids, saponins, flavonoids and steroids, while the terpenoid and phenolic compounds were not identified. Thus, the methanol extract of gonggong snail meat has antibacterial potential that can be used to overcome the attack of pathogenic bacteria.
Potential of extract leaf cherry (Muntingia calabura L) on production macrophage mice (Mus musculus) Syahran Wael; Ana Bina Sari; Ine Arini; Milka Gabriel Lestuny
BIOEDUPAT: Pattimura Journal of Biology and Learning Vol 3 No 1 (2023): Bioedupat : Pattimura Journal of Biology and Learning
Publisher : Program Studi Pendidikan Biologi, Pascasarjana, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/bioedupat.v3.i1.pp95-101

Abstract

The cherry plant (Muntingia calabura L.) is a shrub or small tree only up to 12 meters high, although generally only around 3-6m. The purpose of this study was to see the application of cherry leaf extract to mice infected with Salmonella typimirium. This research is a laboratory experimental study with a post test-only control group design using Balb/c mice as the research object. This research was conducted from 10 February to 15 April 2022. The extract of cherry leaves was used at the basic biology laboratory of Pattimura University. The mice used were adult male mice aged 3 months and weighing about 20 grams. Macrophage analysis was measured from the spleen of mice using the SPPS 20 One Way Anova test and then continued with the LSD follow-up test. The results of the study showed that in the control group the average weight of the spleen was 0.126 lighter because it was not infected with Salmonella typimerium compared to the treatment of cherry leaf extract infected with Salmonella typimerium) dose of 15 mg/kgbw (0.556), dose of 75 mg/kgbw (0.516) and a dose of 150 mg/kgbw (0.510). While there was no significant difference in macrophages. Salmonella typimurium infection will initiate an inflammatory response at the site of spread of the bacteria, including reaching the spleen and causing enlargement of the spleen.
Analysis Antioxidant of Clove Leaves (Syzygium aromaticum) as a Source of Bioactive Compounds Syahran Wael; Ine Arini; Marike Muskita; Heinrich Rakuasa
RUMPHIUS Vol 8 No 1 (2026): RUMPHIUS Pattimura Biological Journal
Publisher : Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/rumphiusv8i1p047-054

Abstract

This study aimed to evaluate the antioxidant activity of the chloroform extract of clove leaves (Syzygium aromaticum) as a source of bioactive compounds. Unlike most previous studies that predominantly focused on essential oils or polar extracts of clove, this research specifically investigates the antioxidant potential of the semi-polar chloroform extract, which remains relatively underexplored. Extraction was performed using chloroform to obtain semi-polar compounds with potential biological activity. Phytochemical screening revealed the presence of phenolic compounds, flavonoids, tannins, and terpenoids, which are known to function as natural antioxidants. Antioxidant activity was assessed using the DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging assay based on the ability of the sample to neutralize free radicals. The results demonstrated an increase in percentage inhibition with increasing extract concentration, indicating a positive linear relationship between concentration and antioxidant activity. Linear regression analysis yielded an IC₅₀ value of 69.40 ppm, classifying the extract as having strong antioxidant activity. In comparison, ascorbic acid exhibited an IC₅₀ value of 8.75 ppm, indicating very strong antioxidant activity. This difference is attributed to the nature of ascorbic acid as a pure compound, whereas the chloroform extract consists of a complex mixture of secondary metabolites. The novelty of this study lies in highlighting the significant antioxidant potential of the semi-polar chloroform fraction of clove leaves, thereby expanding the understanding of solvent-specific bioactive compound distribution and providing new insight into its possible application in functional food and pharmaceutical development. Overall, the findings suggest that the chloroform extract of clove leaves has promising potential as a natural source of bioactive compounds for further development.
Co-Authors Ana Bina Sari Frans Selfanay Fredy Leiwakabessy Heinrich Rakuasa Ine Arini Johanis Fritzgal Rehena Marike Muskita Milka Gabriel Lestuny Theopilus Wilhelmus Watuguly Theopilus Wilhelmus Watuguly Windi Mose