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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Mutiara Medika: Jurnal Kedokteran dan Kesehatan Berkala Kedokteran The Indonesian Biomedical Journal JPKMI (Jurnal Publikasi Kesehatan Masyarakat Indonesia) JOURNAL SCIENTIFIC OF MANDALIKA (JSM) Smart Society Empowerment Journal
Windy Yuliana Budianto, Windy Yuliana
Department Of Pediatric Nursing, Faculty Of Medicine, Universitas Lambung Mangkurat, Jl. Ahmad Yani Km.36, Banjarbaru 70712
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Dentistry Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Other

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A Different Approach to Assess Oxidative Stress in Dengue Hemorrhagic Fever Patients Through The Calculation of Oxidative Stress Index Edi Hartoyo; Iskandar Thalib; Cynthia Maharani Puspita Sari; Windy Yuliana Budianto; Eko Suhartono
Journal of Tropical Life Science Vol. 7 No. 3 (2017)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.07.03.08

Abstract

The objectives of this study were to determine the involvement of Oxidative Stress (OS) in the pathogenesis of dengue hemorrhagic fever (DHF) through the analysis of oxidative stress Index (OSI). The levels of malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) activity, and OSI were measured in 61 child dengue patients and (aged 6 months–18 years) with three different stages of DHF, i.e stage I, II, and III. The results show that the levels of MDA, SOD and CAT activity, and OSI significantly different between the group. The all parameters that investigated in this present study seems higher MDA level and OSI in the higher grade of DHF, except for SOD and CAT activity. From this result, it can be concluded that oxidative stress pathways might be involved in the pathomechanism of DHF and OSI might be used as a biomarker for OS and the severity in DHF patients.
Co-Authors Agung Biworo Agung Biworo Amalia Fitriyana Cahyadi, Herry Cynthia Maharani Puspita Sari Edi Hartoyo Edi Hartoyo Edyson Edyson, Edyson Eko Suhartono Eko Suhartono Fahira, Nurul Savira Husnul Khotimah Iskandar Iskandar Lisda Hayatie, Lisda Reni Saufi Jayanti Rifaldi Rismia Agustina Sekartaji, Hapsari Lintang Sophia Hasanah Yogi Waskito Aji