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All Journal Journal Of Widya Medika Junior Jurnal Widya Medika
Leonardo Suryanto Wicaksono
Faculty of Medicine, Widya Mandala Surabaya Catholic University
Medicine & Pharmacology Public Health

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THE EFFECT OF PERORAL POLYVINYL CHLORIDE MICROPLASTIC ON ALKALINE PHOSPHATASE AND GAMMA-GLUTAMYL TRANSFERASE LEVELS IN RATTUS NORVEGICUS WISTAR STRAIN Leonardo S Wicaksono; Yudhiakuari Sincihu; Adi P Hendrata
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 4, No 3 (2022): July
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v4i3.4093

Abstract

Introduction: Human exposure to microplastics continues to rise. Microplastics are harmful and are suspected of contributing to various health problems in humans, including reduced liver function.Purpose: This study aimed to determine the effect of oral polyvinyl chloride microplastic consumption on alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT) levels in Rattus norvegicus Wistar strain.Method: Male Rattus norvegicus Wistar strain experiments were separated into control and experimental groups, with the experimental group receiving a 0.5 mg/day dose of polyvinyl chloride microplastic. The experimental animals' blood was taken using the cardiac puncture technique, and the ALP and GGT levels were determined using the kinetic photometric test method.Result and Discussion: The Shapiro-Wilk normality tests showed that the ALP variable from the control group (P=0.342) and the experimental group (P=0.727) was significantly different from the GGT variable from the control group (P=0.482) and experimental group (P=0.099). Thus, the data for the ALP and GGT variables are claimed to be normally distributed. The ALP variable (P = 0.237) and the GGT variable (P = 0.839) both passed the significant homogeneity test, indicating that the ALP and GGT variable data were homogeneous. The independent comparison test T-test findings indicated that the ALP variable (P=0.602) and the GGT variable (P=0.161) were not statistically significant.Conclusion: The oral administration of polyvinyl chloride microplastic had no significant influence on the ALP and GGT levels in the blood of Rattus norvegicus Wistar strain in the experimental group compared to the control group.
EFFECT OF MICROPLASTIC INTAKE ON INTESTINAL AND PANCREATIC CELL DAMAGE Steven Wijono; Irene Lingkan Parengkuan; Shella Morina; Vincentius Diamantino Supit; David Karunia Jaya; Leonardo Suryanto Wicaksono; Michael Christian Iskandar
JURNAL WIDYA MEDIKA Vol. 8 No. 2 (2022): October
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v8i2.4131

Abstract

Introduction: Microplastics are plastic particles that result from the breakdown of larger plastic particles into smaller pieces and are found in natural environments such as oceans, beaches, and land. Microplastics harm the environment and affect human health. The main entrance of microplastics into the body is the digestive system, through the food and drinks we consume daily. Various investigations have shown that human feces samples contain microplastics that come from ingestion of contaminated food. If it continues, it can damage our body cells. Objective: This research aims to demonstrate that oral administration of microplastics can impair the function of the small intestine, large intestine, and pancreas in rattus of the strain Rattus norvegicus wistar. Method: This study is a quantitative analytic investigation employing an experimental methodology on experimental animals. In this work, the experimental animals were separated into six groups, including the control group and the treatment groups X1, X2, X3, X4, and X5; microscopic observations were conducted 90 days after the microplastics were administered. Results: The comparison of the control group with each exposure group to the small intestine revealed significant results in the Pearson correlation test in groups K with X2, X3, and X4 and the Mann-Whitney difference test in groups K with X2 and X4. Comparing the control group with each exposure group to the large intestine revealed no significant results in the Pearson correlation test and the Mann-Whitney difference test. Conclusion: The correlation test results between the control group and the complete exposure groups revealed significant outcomes in the small intestinal tissue but not in the large intestine and pancreas tissue.
Co-Authors Adi P Hendrata David Karunia Jaya Irene Lingkan Parengkuan Michael Christian Iskandar Shella Morina Sincihu, Yudhiakuari Steven, . Vincentius Diamantino Supit