Putu Dyah Agustina Lestari
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The RESISTANCE TRAINING EFFECT ON IGF1 LEVEL OF SARCOPENIA A A Ayu Tri Bhuana Komala Sari; Nanang Masrani; Ni Ketut Rake Putri Saraswati; Putu Dyah Agustina Lestari; Made Rendra Wisnu Rahasbistara; Nila Wahyuni; I Putu Gede Adiatmika
Sport and Fitness Journal Vol 10 No 2 (2022): Volume 10, No. 2, May 2022
Publisher : Program Studi Magister Fisiologi Keolahragaan, Fakultas Kedokteran, Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/spj.2022.v10.i02.p04

Abstract

ABSTRACT Aging is something that definitely happens and we can't avoid it but we can prevent it. The quality and quantity of muscle mass decreases with age. Sarcopenia is a decrease in muscle mass accompanied by a decrease in muscle strength. Muscle metabolism is influenced by many factors and signaling pathways. The level of IGF-1 plays an important role in maintaining the quality of skeletal muscle. Recent studies have shown that resistance training is essential for muscle development and increasing the efficiency of agonist and antagonist muscle groups. However, research on this topic varies greatly in terms of the frequency, intensity, duration, and type of exercise that builds IGF-1. The study was conducted using the literature method. We reviewed and compared the most recent journals discussing the relationship between sarcopenia and regular long-term physical exercise. Physical exercise with resistance training showed significant results for muscle strength and muscle mass in the elderly. High-resistance training has a major effect on increasing GH and cortisol. In conclusion, certain physical activities have a positive effect on muscle health that can be withdrawn by IGF1. Keywords: Sarcopenia; IGF-1; Resistance training
The Urgency of Karyotyping Examination in Male Infertility Patients with Primary Hypogonadism Putu Dyah Agustina Lestari; I Gusti Ngurah Pramesemara
Indonesian Andrology and Biomedical Journal Vol. 4 No. 2 (2023): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/iabj.v4i2.50468

Abstract

Infertility is a failure to get pregnant after one year of sexual intercourse without using contraception. The causes of infertility, especially in men, are very complex, including the aging process, hormonal disorders, lifestyle, environment, metabolic disease, and genetic problems. One of the most difficult causes in male infertility  is genetic problems. In this case, a 35 year old man was reported with primary infertility and often experienced premature ejaculation and even anejaculation. Previously, the patient had repeatedly consulted about his condition at other fertility service centers. The conclusion obtained was that the patient had azoospermia with bilateral varicoceles and had been given hormone therapy but had not yet found a final diagnosis so the patient was still confused about what had happened to him. At the first visit the patient underwent a sperm analysis and the results were azoospermia. Then, based on the results of the history and physical examination, which indicated hypogonadism, a Y chromosome microdeletion examination was carried out, and a deletion was found in the AZFc region, which is a marker of infertility that causes spermatogenic failure. The examination was continued with karyotyping, the result was 47.XXY, consistent with the condition of Klinefelter syndrome. Conclusion: Carry out a karyotyping examination if you find signs and symptoms that suggest primary hypogonadism in male infertility. This can be done to streamline the diagnostic approach time in patients with primary hypogonadism, especially those with infertility.