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All Journal Jurnal Farmasi Indonesia JURNAL FARMASIMED (JFM) Indonesian Journal of Pharmacy and Natural Product
faizal Mustamin
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Medicine & Pharmacology

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Pengaruh Variasi Konsentrasi Gelling Agent Terhadap Sifat Fisik Dan Efek Antibakteri Sediaan Gel Handsanitizer Ekstrak Bawang Dayak faizal Mustamin; Irma Novrianti
Jurnal Farmasi Indonesia Vol 19 No 2 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i2.1541

Abstract

Currently, there are many alcohol-based hand sanitizers on the market. Alcohol-based products when used in the long term can cause irritation, so it is necessary to develop Handsanitizer preparations that use active substances other than alcohol. Onion Dayak (Eleutherine palmifolia (L.) Merr.) is a typical Kalimantan plant that has antibacterial properties. The purpose of this study was to examine the effect of variations in the concentration of gelling agent in the hand sanitizer gel preparation of Dayak onion extract on the physical properties and antibacterial effects of S. aureus and E. coli bacteria. Gel Handsanitizer preparations were made using the gelling agent carbopol with 3 variations in concentration, namely FI (carbopol 0.3%), FII (carbopol 0.4%), and FIII (carbopol 0.5%). The finished preparation will be tested for physical properties such as organoleptic, pH, viscosity and homogeneity. To see the antibacterial effect of the hand sanitizer, Dayak onion extract was tested on S. aureus and E. Coli bacteria. The hand sanitizer preparation of Dayak onion extract produced has a maroon color, has a distinctive odor, and is homogeneous. The results of the physical properties test showed that the viscosity and pH would increase with increasing gelling agent concentration, while the dispersion decreased with p < 0.05. The results of the test on S. aureus bacteria for FI, FII, FIII, and positive control showed a weak category, while the E. Coli bacteria showed a moderate category for FI, and a strong category for FII, FIII, and positive control with p value > 0, 05. The negative control did not form an inhibition zone. Variations in the concentration of geling agent (carbopol) had an effect on the physical properties of the hand sanitizer gel preparation of Dayak onion extract, but did not affect its effectiveness against S. aureus and E. coli bacteria.
Identifikasi Senyawa Flavonoid Ekstrak Etanol 96% Cacing Tambelo (Bactronophorus Thoracites) Menggunakan Metode KLT: Identification of Flavonoid Compounds of 96% Ethanol Extract of Tambelo Worm (Bactronophorus Thoracites) Using KLT Method Ayu Andira; Jufri Ubrusun; Faizal Mustamin
Indonesian Journal of Pharmacy and Natural Product Vol. 8 No. 01 (2025): Indonesian Journal of Pharmacy and Natural Product
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35473/ijpnp.v8i01.3713

Abstract

Tambelo worms (Bactronophorus thoracites) are worms that live in decaying mangrove trees. The purpose of this study was to analyze the flavonoid compound content in tambelo worms (Bactronophorus thoracites) from Tepian Village, North Kalimantan Province. This study uses descriptive observational method which includes the examination of data on the identification of secondary metabolite compounds, especially color changes in thin layer chromatography test results in the form of retention factor (RF) values. The tambelo worms used in this study have been determined at the National Research and Innovation Agency (BRIN) in December 2024. In this study, the extraction method is maceration method and the identification of flavonoid compound using Thin Layer Chromatography (TLC). The results of tambelo worm extract after spraying cyroborate reagent produced a yellow stain (RF = 0.40), and produced a bright blue fluorescent stain (RF = 0.38) when observed using UV light 366 nm. The conclusion from the results of this study is that tambelo worm extract (Bactronophorus thoracites) is positive for flavonoids. Thin Layer Chromatography test results using mobile phase n-hexan:ethyl acetate (1:3) for flavonoids.   ABSTRAK Cacing tambelo (Bactronophorus thoracites) merupakan cacing yang hidup dipohon bakau lapuk dan membusuk. Tujuan penelitian ini untuk menganalisis kandungan senyawa flavonoid pada cacing tambelo (Bactronophorus thoracites) asal Desa Tepian Provinsi Kalimantan Utara. Penelitian ini menggunakan metode observasional deskriptif yang meliputi pemeriksaan data hasil identifikasi senyawa metabolit sekunder, khususnya perubahan warna pada hasil uji kromatografi lapis tipis berupa nilai faktor retensi (RF). Cacing tambelo yang dipakai pada penelitian ini telah dideterminasi di Badan Riset dan Inovasi Nasional (BRIN) pada bulan desember 2024. Pada penelitian ini ekstraksi menggunakan metode maserasi dan pengujian senyawa flavonoid menggunakan kromatografi lapis tipis (KLT). Hasil ekstrak cacing tambelo setelah penyemprotan reagen sitroborat menghasilkan bercak noda berwarna kuning (RF= 0,40), dan menghasilkan bercak noda berflourisensi biru terang (RF= 0,38) pada saat diamati menggunakan sinar UV 366 nm. Kesimpulan dari hasil penelitian ini bahwa ekstrak cacing tambelo (Bactronophorus thoracites) positif mengandung flavonoid. Hasil uji Kromatografi Lapis Tipis menggunakan fase gerak n-heksan:etil asetat (1:3) untuk flavonoid.
Physical Stability Test of Anti-Acne Cream from Ethanol Extract of Seruni Leaves (Spaghneticola trilobata) on Different Bases Sari Wijayanti; Faizal Mustamin; Muhammad Luthfi
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/8zkc4p63

Abstract

One of the formulations commonly used in treating acne is cream. However, most creams contain chemicals that can irritate the skin. Therefore, an alternative solution should be to use natural antibacterial ingredients. There is scientific evidence that chrysanthemum leaves (Spaghneticola Trilobata) have antimicrobial activity due to their secondary metabolite content consisting of terpenoids, flavonoids, steroids, tannins, saponins, and alkaloids. In this study, Chrysanthemum Leaf extract will be formulated into a physically stable anti-acne cream. To make chrysanthemum leaf ethanol extract cream, the concentration of stearic acid and TEA was varied. The amount of extract used to make the cream is 2.5%. Different concentrations of TEA:Stearic acid, namely F1 (0.2%:5%), F2 (0.4%:10%), and F3 (0.6%:15%). Type M/A cream that extracts ethanol from chrysanthemum leaves produces a semi-solid texture, olive green color, and characteristic odor of chrysanthemum leaves. After homogeneity test, the cream is said to be homogeneous because there are no coarse particles. The pH value of this cream is around 6-7, so it is safe to apply on the face. The spreadability test of Formula I, which reached 5.65 cm, met the standard for good cream spreadability, and the stickiness test, which lasted for 4.57 seconds, showed that this cream met the criteria for good stickiness. Formula I (F1) is the best formula that meets the criteria for a quality cream, according to the physical stability test results.
Co-Authors Ayu Andira Chatarina Umbul Wahyuni Irma Novrianti Jufri Ubrusun Sari Wijayanti