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All Journal Bionature Sainsmat : Jurnal Ilmiah Ilmu Pengetahuan Alam
Yenni Yusuf
Universitas Hasanuddin
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology

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Analisis Mutasi Gen Pfmdr1 1246 pada Penderita Malaria di Mamuju Sulawesi Barat Yenni Yusuf; Hartono Hartono; Syafruddin Syafruddin
SAINSMAT: Jurnal Ilmiah Ilmu Pengetahuan Alam Vol. 2 No. 2 (2013): Volume 2 Nomor 2 (September 2013)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Negeri Makassar

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Plasmodium falciparum has the ability to develop resistence to anti-malarial drugsthrough mutations at some genes, including Plasmodium falciparum multi-drug resistanceprotein 1 (Pfmdr1). Pfmdr1 mutations might occur at some codon positions, includingposition 1246 in which aspartatic acid is changed into tyrosine. It is suggested that themutant allele, 1246Y, is related to treatment failures with amodiaquine, an anti-malarialdrug. The aim of this research is to analyse the mutation of Pmdr1 1246 in malaria patients who will receive treatment with combination of artesunate-amodiquine (AS-AQ). From 18samples, none has the allele of 1246 Y. Follow up to the patients until day 28 shows thatAS-AQ is clinically effective to treat malaria.
Evaluasi Rasio Netrofil Limfosit (RNL) untuk diagnosis COVID-19 pada Pasien di RS Tadjuddin Chalid, Makassar, Indonesia Yenni Yusuf; Sitti Nurisyah; Ammar Abdurrahman Hasyim; Khaeriah Amru; Atifatul Qalbi Kadir; Azizah Nurul Mutia; Muhammad Naufal Zuhair; Kartika Paramita
Bionature Vol. 22 No. 2 (2021): Oktober 2021
Publisher : Jurusan Biologi Universitas Negeri Makassar

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The neutrophil lymphocyte ratio (NLR) is one of the variables related to the severity of COVID-19 disease. Therefore, we evaluated the value of NLR in COVID-19 patients and its relation to the symptoms and severity of COVID-19 at Tadjuddin Chalid Hospital, Makassar. We recruited patients visiting Tadjuddin Chalid Hospital Makassar who were willing to take part in the study in April to August 2021. Demographic, clinical and laboratory data were recorded through interviews and medical records. The severity of the disease is classified according to the guidelines from the association of Indonesian pulmonary doctors, Indonesian internal medicine doctors, Indonesian pediatricians, anesthesiologists and intensive care doctors, and the Indonesian cardiologist association. NLR data was obtained by calculating the ratio between neutrophil levels and lymphocyte levels in the blood. A total of 130 patients took part in the study, between 19-72 years old. There were 77 subjects (59.2%) with mild symptoms, 28 (21.6%) with moderate symptoms, and 25 (19.2%) with severe symptoms. There were 89 subjects with NLR <3.5 (68.5%) and 41 (10.8%) with NLR > 3.5. NLR values in patients with severe and moderate disease were significantly different from NLR in patients with mild disease (p =0.0002 dan p<0.0001, respectively). However, no significant difference was found in NLR between patients who neither have cough nor fever with those who had one or both of those symptoms. The presence of clinical or radiological symptoms of pneumonia accompanied by an NLR > 3.5 can be used as an indicator for a suspected moderate or severe COVID-19 diagnosis.
Tinjauan Molekuler dan Epidemiologi Mutasi pada Virus SARS-CoV-2 Hartono; Yenni Yusuf
Bionature Vol. 22 No. 1 (2021): April 2021
Publisher : Jurusan Biologi Universitas Negeri Makassar

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Virus SARS-CoV-2 yang merupakan penyebab pandemi COVID-19 sejakakhir tahun 2019 telah mengalami banyak mutasi yang memunculkan beberapavariants of concern (VOC) dengan penularan, virulensi, dan kemampuanmenghindari sistem imun yang lebih tinggi daripada varian awal (wild-type). Hinggakini terdapat empat varian yang termasuk dalam VOC virus tersebut yaitu varianalfa, beta, gamma, dan delta. Peningkatan transmisi dan virulensi pada VOC tersebutdikaitkan dengan perubahan mutasi pada protein spike yang merupakan strukturdari virus yang berperan dalam pengikatan dengan sel host. Pada artikel ini kamimelakukan literature review mengenai VOC dari virus SARS-CoV-2 terkait mutasiyang terjadi dan dampaknya pada proses pengikatan virus. Untuk mendapatkanpemahaman terkait dampak dari mutasi di berbagai varian tersebut, kami jugamereview struktur dari protein spike dan proses entry virus ke dalam sel host.
Co-Authors Ammar Abdurrahman Hasyim Atifatul Qalbi Kadir Azizah Nurul Mutia Hartono Hartono Hartono Kartika Paramita Khaeriah Amru Muhammad Naufal Zuhair Sitti Nurisyah Syafruddin Syafruddin