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All Journal Radioterapi & Onkologi Indonesia
Endang Nuryadi
Unit Pelayanan Onkologi Radiasi, Fakultas Kedokteran Universitas Indonesia, RS. Dr. Cipto Mangunkusumo, Jakarta
Education Health Professions Medicine & Pharmacology Physics Other

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The Role of Radiotherapy towards Pediatric Cancer Agustinus Darmadi Hariyanto; Hari Murti Wijaya; Jellyca Anton; Seize Edwiena Yanuarta; Steven Octavianus; Handoko Handoko; Endang Nuryadi; Soehartati Argadikoesoema Gondhowiardjo
Radioterapi & Onkologi Indonesia Vol 11, No 2 (2020): VOLUME 11 NO.2 JULY 2020
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32532/jori.v11i2.117

Abstract

Cancer is the leading cause of death in children worldwide. Pediatric cancer is challenging to detect early because it generally appears with signs and symptoms that are not typical. The increase in cancer cases in pediatric must be followed by an increase in cancer management in all fields of scientific disciplines. Radiation oncology, as one of the areas of science, has an essential role in definitive, adjuvant, palliative, and prophylactic cancer in pediatric. Apart from these uses, radiation management is a significant contributor to the complications of pediatric cancer survivors. Complications that arise can be in the form of growth retardation, tissue changes, secondary cancer, neurocognitive changes, infertility, or other hormonal dysfunction and preterm labor. An increase in radiation techniques followed the development of treatment machines able to reduce radiation-related morbidity and mortality rates. In pediatric radiotherapy, the entire process from the pre-procedure anesthesia to radiotherapy requires special attention. Psychological issues are also worth observing. This study will briefly discuss these matters and the management of some of the most common pediatric cancers in Dr. Cipto Mangunkusumo Hospital.
Perbandingan Respon Terapi Radiasi Antara Teknik Konvensional 2D dengan Pengecilan Lapangan Radiasi Teknik 2D, 3DCRT atau Brakiterapi pada Kanker Nasofaring Stadium Dini di Departemen Radioterapi RSUPN Cipto Mangunkusumo Endang Nuryadi; Soehartati Argadikoesoema Gondhowiardjo; Marlinda Adham
Radioterapi & Onkologi Indonesia Vol 6, No 2 (2015): Volume 6 No.2 Juli 2015
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1067.796 KB) | DOI: 10.32532/jori.v6i2.35

Abstract

Studi retrospektif ini bertujuan untuk mengetahui perbandingan respon terapi radiasi antara teknik konvensional 2D dengan pengecilan lapangan radiasi teknik 2D, 3DCRT atau brakiterapi pada pasien kanker nasofaring stadium dini (stadium I – IIa). Dari 20 sampel didapatkan respon komplit pada 17 pasien (85%) dan respon parsial pada 3 pasien (15%) (p=0.219). Efek samping akut yaitu dermatitis radiasi grade 3-4 adalah 5% (p=0.435), mukositis grade 3-4 adalah 15% (p=0.510) dan xerostomia grade 3-4 adalah 0% (p=0.517). Secara statistik tidak didapatkan perbedaan bermakna tetapi secara klinis mempunyai kesan ada kecenderungan bahwa dengan pengecilan lapangan radiasi teknik brakiterapi dan 3D-CRT lebih baik dalam hal efek samping akut mukositis dibanding teknik 2D
Combination of Adoptive Cell Therapy and Radiotherapy in Cancer Management Vito Filbert Jayalie; Endang Nuryadi
Radioterapi & Onkologi Indonesia Vol 13, No 1 (2022): Volume 13 No.1 January 2022
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32532/jori.v13i1.137

Abstract

Cancer remains a healthcare burden in the world, with the increasing cases and deaths. Adoptive cell therapy (ACT) is one of the immunotherapies which modifies immune system to recognize cancer cells, which is then transfused to induce antitumoral responses in the human body. ACT works by using cancer-specific immune cells, especially Natural Killer and T cells in the form of tumor-infiltrating lymphocytes, T-cell receptor or chimeric antigen receptor. As the combination therapy with radiotherapy, radiation is able to induce tumor-associated antigen (TAA) and major histocompatibility complex (MHC) class I expression, which leads to increased immune cells around the tumor. As the result, transferred ACT to the body may be able to proliferate and perform its function well. Moreover, radiotherapy is able to downregulate regulatory T cells and myeloid-derived suppressor cells which can inhibit the role of the immune system in attacking cancer. Clinically, studies combining radiation and ACT in cancer care are limited to several types of cancer, such as metastatic melanoma, nasopharyngeal cancer, lymphoma and non-small cell lung cancer. Radiotherapy is able to increase therapeutic efficacy, especially as a bridging therapy before ACT. Nevertheless, further trials to know the potency of combining ACT and radiotherapy in other types of cancer, especially in earlier stages are needed.
Co-Authors Agustinus Darmadi Hariyanto Handoko Handoko Hari Murti Wijaya Jellyca Anton Marlinda Adham Seize Edwiena Yanuarta Soehartati Argadikoesoema Gondhowiardjo Soehartati Argadikoesoema Gondhowiardjo Steven Octavianus Vito Filbert Jayalie, Vito Filbert