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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Jurnal Impresi Indonesia
Nicolas Xavier Ongko
Universitas Prima Indonesia
Religion Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Public Health Social Sciences

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UJI TOKSISITAS AKUT EKSTRAK KUNYIT PUTIH (CURCUMA ZEDOARIA) TERHADAP GAMBARAN HISTOPATOLOGI PANKREAS Erny Tandanu; Veronica Lawrence; Stephanie Taniwan; Chairul Radjab Nasution; Nicolas Xavier Ongko
JURNAL KEDOKTERAN DAN KESEHATAN Vol 9, No 3 (2022)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/JKK.V9I3.19107

Abstract

Kunyit putih (Curcuma zedoaria) banyak digunakan oleh masyarakat luas karena dipercayai sebagai tanaman herbal yang bermanfaat dalam mengobati bermacam penyakit. Curcumin yang merupakan salah satu kandungan kunyit putih diyakini mempunyai manfaat sebagai antioxidan, anti inflamasi, anti mikroba, anti kanker, anti aterosklerosis dan anti diabetes. Secara umum, kepercayaan masyarakat tehadap penggunaan kunyit putih sebagai pengobatan herbal memiliki efek samping yang minimal jika dibandingkan dengan obat modern, namun penelitian mengenai efek samping dari penggunaan kunyit putih belum banyak diteliti. Tujuan dari penelitian ini adalah agar mengetahui uji toksisitas akut ekstrak kunyit putih (Curcuma zedoaria) terhadap gambaran histopatologi pankreas. Penelitian ini merupakan penelitian eksperimental yang menggunakan design Post Test Only Control Group Design dengan 30 ekor Rattus norvegicus  jenis kelamin jantan dengan berat berkisar antara 150-300 gram. Tikus putih dibagi menjadi kontrol negatif aquades dan kontrol positif NaCMC 1%, dan 4 kelompok perlakuan ekstrak kunyit putih dengan dosis 250 mg/KgBB, 500 mg/KgBB, 750 mg/KgBB, dan 2000 mg/KgBB. Hasil yang didapat bahwa ekstrak kunyit putih (Curcuma zedoaria) tidak menunjukkan efek toksisitas akut pada pancreas tikus putih berupa tidak adanya nekrosis, edema dan sel radang pada  gambaran histologi pankreas. 
THE RELATIONSHIP OF THE NUMBER OF NEUTROFIL LYMPHOCYTE RATIO WITH THE PICTURE OF COLITIS Agita Angela Br Tarigan; Nicolas Xavier Ongko; Edlin Edlin
Jurnal Impresi Indonesia Vol. 3 No. 2 (2024): Jurnal Impresi Indonesia
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jii.v2i12.4037

Abstract

Colitis is an acute or chronic inflammation of the colon. The gold standard for diagnosis and monitoring of disease activity in colitis patients is endoscopy combined with pathology biopsy. However, endoscopy has disadvantages related to invasiveness, cost, and feasibility of use for long-term follow-up. The neutrophil-lymphocyte ratio is a simple biomarker that can serve as a useful biomarker for diagnosing and predicting mucosal inflammation in colitis. This study aims to determine whether there is an influence between the number of neutrophil-lymphocyte ratios and the appearance of colitis. This research is a cross-sectional observational analytical research. In this study, 44 medical record data were used. A total of 44 colitis medical record data for the 2022-2023 period were collected. The largest age group is 61-70 years with 11 people (25%), based on the gender group the largest is male with 30 people (68.2%), and based on histopathology the largest is 25 (56.8%) patients. who suffers from chronic colitis. However, in the study, there was no relationship between the neutrophil-lymphocyte ratio and the appearance of colitis, P = 0.22 (P value> 0.05) and the Prevalence Ratio 95% CI 1,436 (0,832-2,476). Based on the results of this study, the majority of patients are male, based on the patient's age, the majority is between 61-70 years, and based on the histopathology picture, the majority is chronic colitis. However, in the study, there was no relationship between the neutrophil-lymphocyte ratio and the appearance of colitis, P = 0.22 (P value > 0.05), and the 95% Prevalence Ratio was 1,436 (0,832-2,476).
Co-Authors Agita Angela Br Tarigan Chairul Radjab Nasution Edlin Edlin Erny Tandanu Stephanie Taniwan Veronica Lawrence