<![CDATA[Penemuan jenis antibiotik baru diimbangi dengan penemuan resistensi dari bakteri tersebut terhadap beberapa obat.Secara garis besar, antibiotik dibagi menjadi tiga golongan berdasarkan cara kerja, spektrum, dan efek bakterisidal.Terapi antibiotik terhadap pasien kritis merupakan hal yang menjadi perhatian di dunia akibat tingginya mortalitasdan morbiditas. Aspek efektifitas terapi terus menjadi perhatian akibat peningkatan kebutuhan ruang Intensive CareUnit. Kontrol infeksi dan pemilihan antibiotik yang sesuai merupakan intervensi utama dan harus menjadi prioritasdalam manajemen pasien kritis. Pengetahuan mengenai farmakokinetik dan farmakodinamik antibiotik merupakanfaktor yang esensial karena penentuan dosis antibiotik berkaitan dengan keluaran pasien kritis. Perubahan padavolume of distribution dan clearance antibiotik pada pasien kritis mungkin berefek pada target konsentrasi obatdalam serum. Hal ini menjadi bukti bahwa parameter pharmacokinetics (PK)/pharmacodynamics (PD) berperanterhadap efek obat yang terkait dengan keluaran pasien dan resistensi.
Kata kunci: Antibiotik, farmako dinamik, farmako kinetik, ICU, pasien kritis
The discovery of new types of antibiotic resistance offset by the discovery of bacteria to multiple drugs. In general,antibiotics are divided into three groups based on the spectrum shape, and the bactericidal effect. Antibiotictherapy for critically ill patients is a concern in the world due to the high mortality and morbidity. Aspects of theeffectiveness of therapy remains a concern due to the increasing needs of the ICU. Pemilihian infection controland appropriate antibiotic is a major intervention and should be a priority in the management of patients in criticalcondition. Knowledge of the pharmacokinetics (PK) and pharmacodynamics (PD) of antibiotics is essential todetermine the doses of antibiotics related to production factor of critically ill patients. Changes in the volumeof distribution and clearance of antibiotics in critically ill patients may have an effect on a target serum drugconcentrations. This is proof that the PK/PD parameter contribute to the effects associated with the drug and theoutput resistance of the patient.
Key words: Antibiotic, Critical patients, ICU, pharmacodynamis, pharmacokinetis
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