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All Journal Journal of Dentomaxillofacial Science
Asmawati
Department of Oral Biology, Faculty of Dentistry, Hasanuddin UniversityMakassar, Indonesia
Dentistry

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The increase of fibroblast cells number in rat (rattus norvegicus) gingival wound after the application of moringa (moringa oleifera lam) fruit oil Asmawati; Bahruddin Thalib; Nurhayaty Natsir; Alqarama M. Thalib; Rafikah Hasyim
Journal of Dentomaxillofacial Science Vol. 5 No. 3 (2020): (Available online: 1 December 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/jdmfs.v5i3.1121

Abstract

Objective: To determine the increase of fibroblast cell number in the rat (Rattus norvegicus) gingival wound after the application of moringa (Moringa oleifera Lam) fruit oil.Material and Methods: This study was an experimental post-test control group design using 18 male Wistar rats (Rattus norvegicus) that was divided into three groups. The sample was previously incised with a length of 4 mm using scalpel 15. Group 1 was applied with moringa fruit oil, group 2 was given aspirin, and group 3 was given at 0.5% CMC. The application was carried out every 24 hours, then on the third and seventh day, the rats were euthanized for histological preparations and then observed under the electric microscope. The length of the lesion was measured on the first, third, and seventh days. The fibroblast was then observed by counting the number of fibroblast cells per field of view using an Olympus C-21 microscope with an Optilab Advances camera with a 40x, 100x magnification, and 400x. The data were processed and analyzed using the SPSS Version 21 program. This study used a t-test to see the differences between the treatment group and the control group, and the Least Significantly Difference (LSD) test was used to see the size of the difference.Results: This study showed a significant increase in the number of fibroblasts in rat gingival mucosa on the third and seventh daysConclusion: Moringa (Moringa oleifera Lam) fruit oil affects increasing the number of fibroblasts on the rat gingival mucosa (Rattus norvegicus). 
Potential of moringa fruit (moringa aloifera lamk) seeds as an anti-inflammatory agent of oral cavity lesion Asmawati; Bahruddin Thalib; Nurhayaty Natsir; Fajriani; Alqarama M. Thalib; Delvi S. Reni
Journal of Dentomaxillofacial Science Vol. 6 No. 2 (2021): (Available online: 1 August 2021)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/jdmfs.v6i2.1231

Abstract

Objective: To know the potential of moringa fruit seed extract (moringa Aloifera Lamk) as an anti-inflammatory agent of oral cavity lesion.Methods: One of the natural ingredients that are widely obtained in South Sulawesi is moringa plants and from several researches this plant has been proven to have a variety of properties. Moringa fruit extracts contain components in the form of flavonoids, saponins and tannins. The content serves as an antibacterial and anti-inflammatory. Wound is the loss or partial damage of tissues on the body, one form of wounds that occur in the gingival is a lesion due to irritation, traumatic wounds or wounds due to preoperative incision in the extraction of impacted teeth.Results: Therefore, a natural ingredient that is easily obtained at a low price and not a b-ingredient that is made from chemicals that will provide negative effects such as hypersensitivity and resistance for those who use these drugs.Conclusion: Moringa Oleifera Lamk seed oil has an effect on the formation of collagenase and an increase in the amount of fibroblast so that it has the potential to become an anti-inflammatory drug of the oral cavity.
Co-Authors Alqarama M. Thalib Alqarama M. Thalib Bahruddin Thalib Delvi S. Reni Fajriani Nurhayaty Natsir Rafikah Hasyim