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All Journal The Journal of Pure and Applied Chemistry Research JURNAL INTEGRASI PROSES
Zubaidah Ningsih
Universitas Brawijaya
Chemical Engineering, Chemistry & Bioengineering Chemistry Materials Science & Nanotechnology Medicine & Pharmacology Other

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Comparison of Fabrication Technique and Carrier Oil to Curcumin Nanoemulsion Properties Zubaidah Ningsih; Sepriana Puspita Dewi Syaiful; Maria L.A.D Lestari; Diah Mardiana; Budi Kamulyan
The Journal of Pure and Applied Chemistry Research Vol 12, No 1 (2023): Edition January-April 2023
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2023.012.01.701

Abstract

Turmeric (Curcuma longa L.) is included in the rhizome plant containing curcumin which has various therapeutic properties. However, curcumin has poor bioavailability. The manufacture of nanoemulsion is expected to increase curcumin bioavailability. This study aims to compare 3 methods (wet-ball milling, ultrasonication and microfluidic) and 3 carrier oils (soybean, virgin coconut, and olive oil) in the production of curcumin nanoemulsion. Wet-ball milling reduces particle size through grinding process using milling beads in liquid medium. Microfluidic decreases the particle size via collision of emulsion components in microchannel while ultrasound utilizes sound-wave energy to break down the particle size. Parameters compared were particle size, polydispersity index and entrapment efficiency. Particle size and polydispersity index were observed using Particle Size Analyzer with Dynamic Light Scattering technique while entrapment efficiency was measured based on the curcumin absorbance in UV-Visible spectrophotometer at 420 nm. Our study concludes that microfluidic is the most effective and efficient fabrication method which produces the smallest particle size and polydispersity index compared to ultrasonication and microfluidic. The resulting particle sizes using microfluidic are 154, 140 and 132 nm with polydispersity index of 0.224; 0.200and 0.208 insoybean,virgin coconut, and oliveoil respectively. However, entrapment efficiency is best achieved using wet-ball milling method with the average value of 49±10%. Soybean oil appears to be the most curcumin solubilizing oil compared to olive and virgin coconut oil. Thus, it can be concluded that fabrication methods and carrier oils determine curcumin nanoemulsion properties.
STUDI IN VITRO NANOEMULSI GEL ANTIJERAWAT EKSTRAK KULIT DURIAN TERHADAP BAKTERI PROPIONIBACTERIUM ACNES Putri Ayu Maharani; Nur Khasanah; Annindea Erza Novadila; Dzurrotin Qurrota A’yun; Dita Rahmaningtyas; Zubaidah Ningsih
JURNAL INTEGRASI PROSES Vol 11, No 2 (2022)
Publisher : JURNAL INTEGRASI PROSES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36055/jip.v11i2.15308

Abstract

Jerawat atau acne vulgaris merupakan kelainan berupa peradangan pada lapisan polisebaseus disertai adanya penumpukan dan penyumbatan keratin akibat adanya bakteri, salah satunya adalah bakteri Propionibacterium acnes. Penggunaan bahan-bahan alami berpotensi sebagai alternatif bahan aktif untuk pengobatan jerawat. Kulit durian mengandung senyawa antibakteri yaitu flavonoid, saponin, tanin, dan fenolik. Penelitian ini dilakukan dengan tujuan mengetahui efektivitas nanoemulsi gel ekstrak kulit durian dalam menghambat pertumbuhan bakteri Propionibacterium acnes. Uji yang dilakukan meliputi uji fitokimia, organoleptik, homogenitas, pH dan uji inhibisi bakteri. Karakterisasi yang dilakukan meliputi GCMS, FTIR, dan PSA. Gel nanoemulsi dibuat dengan formulasi minyak dalam air dari ekstrak kulit durian menggunakan teknik mikrofluidisasi. Hasil penelitian menunjukkan metode ekstraksi maserasi kulit durian menghasilkan 49 mL ekstrak dari 40 g sampel, senyawa utama antibakteri dalam ekstrak kulit durian adalah 5-Hydroxymaltol dari golongan flavonoid, teknik mikrofluidisasi dalam sistem emulsi menunjukkan potensi menurunkan droplet nanoemulsi, dan efektivitas nanoemulsi gel kulit durian pada konsentrasi 2g.
Co-Authors Annindea Erza Novadila Budi Kamulyan Diah Mardiana Dita Rahmaningtyas Dzurrotin Qurrota A’yun Maria L.A.D Lestari Nur Khasanah Putri Ayu Maharani Sepriana Puspita Dewi Syaiful