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All Journal Widya Warta JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Daya Mas : Media Komunikasi dan Informasi Hasil Pengabdian dan Pemberdayaan Masyarakat Humanism : Jurnal Pengabdian Masyarakat Biospektrum Jurnal Biologi JOMPA ABDI: Jurnal Pengabdian Masyarakat SENAPAS Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Cahyani, Erlien Dwi
Universitas Katolik Widya Mandala Surabaya
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Widya Warta

 1 
VALIDASI METODE ANALISIS SPEKTROFLUOROMETRI UNTUK PENETAPAN KADAR SIPROFLOKSASIN GENERIK DALAM SAMPEL URINMANUSIA Dwi Cahyani, Erlien
Widya Warta No. 01 Tahun XLIV/Januari 2020
Publisher : Universitas Katolik Widya Mandala Surabaya Kampus Kota Madiun

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Abstract

Ciprofloxacin tablet generic usage has been increasing recently due to its economically reason. The generic tablet needed to assure its bioequivalence towards the innovator, one of them by determining  total  amount  of  ciprofloxacin  excreted  in  urine.  The  aim  of  this  research  was  to validate  the  simple,  selective  and  sensitive  spectrofluorometric  analysis  method  to  determine total  amount  of  ciprofloxacin  excreted  in  human  urine  sample  that can  be  developed  for bioequivalence  study  purpose.    Urine  samples  were  obtained  from  the  subjects  of  six  healthy men  who  were  asked  to  take  ciprofloxacin  tablet.  The  assay  of  ciprofloxacin  in  tablet preparation  were  tested  its  validation  according  to  linearity,  accuracy,  precision,  limits  of detection  (LOD)  and  limits  of  quantitative  (LOQ).  The  validation  parameter  with  analysis method  obtained  linear  regression  curve  Y  =  0,6878X  +  2,8332  (r  =  0,9994)  with  limits  of detection  and  limits  of  quantitation  were0,0721  μg/ml  and  0,2402  μg/ml  respectively, coefficient  of  variation  of  0,0036%,  and  accuracy  value  of  92,81  %.  The  total  amount  of ciprofloxacin excreted was within the range of 270,19 μg/ml to 341,91 μg/ml.
Co-Authors Agus Purwanto AGUS PURWANTO Antonius Budiawan Bida Cincin Kirana Damayanti, Windy Aulia Imawati, Maria Fatmadewi Indriasari, Christina Kirana, Bida Cincin Leo Eladisa Ganjari Levi Puradewa Maria Fatmadewi Imawati Nur Wijayanti, Andita Nurcahyani, Diah Vidya Kartikaningrum Yohana Mitta Puspitasari