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All Journal INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal) Medical Sains : Jurnal Ilmiah Kefarmasian Bangun Desa : Jurnal Pengabdian Masyarakat Medical Sains : Jurnal Ilmiah Kefarmasian
Adhi Gunawan
Universitas Alma Ata
Religion Computer Science & IT Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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FORMULATION, EVALUATION OF PHYSICAL PROPERTIES AND ANTIOXIDANT ACTIVITY OF ETHANOL EXTRACT AND ETHYL ACETATE FRACTION GEL OF Moringa oleifera LEAVES Annisa Fatmawati; Rizal Fauzi; Adhi Gunawan; Riza Kurniawati; Depita Sucianingsih; Sain Abrari
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 7 No 4 (2022)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v7i4.433

Abstract

The leaves of Moringa (Moringa oleifera Lam) contain quercetin, a flavonoid that plays a role in the skin regeneration process with an antioxidant mechanism, can play a role in the healing process of skin wounds. The ethanol extract of Moringa leaves was fractionated using petroleum ether and ethyl acetate. The MLEE (Moringa leaf ethanolic extract) gel formula was made to vary the extract weights in the order of 2%, 4% and 6% (b/b), while EFML (Moringa leaf ethyl acetate fraction) gel preparations were made to vary the extract weights in the order of 1%, 2% and 4% (b/b). Evaluation of the physical properties of the gel preparations, including organoleptic observation, homogenity tests, pH measurements, spreadability tests, adhesion tests, and antioxidant activity using the DPPH method. The physical properties of all preparation fulfill the requirements. The test for antioxidant gel MLEE IC50: MLEE 1 144.72 ± 3.52 ppm; MLEE 2 138.15 ± 0.93 ppm; MLEE 3 136.59 ± 1.68 ppm when compared to extracts IC50 MLEE 23.14 ppm (very strong antioxidant activity). The EFML gel formulation (IC50: EFML 1 208.81 ± 4.09 ppm; EFML 2 193.22 ± 2.53 ppm; EFML 3 182.48 ± 2.11 ppm) gave the same results when compared to the thick fraction of Moringa leaves, which has moderate antioxidant activity. The formula gel MLEE 3 has moderate antioxidant activity, which is the best gel formulation based on the results of physical properties test.
FORMULATION, EVALUATION OF PHYSICAL PROPERTIES AND ANTIOXIDANT ACTIVITY OF ETHANOL EXTRACT AND ETHYL ACETATE FRACTION GEL OF Moringa oleifera LEAVES Annisa Fatmawati; Rizal Fauzi; Adhi Gunawan; Riza Kurniawati; Depita Sucianingsih; Sain Abrari
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 7 No 4 (2022)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v7i4.433

Abstract

The leaves of Moringa (Moringa oleifera Lam) contain quercetin, a flavonoid that plays a role in the skin regeneration process with an antioxidant mechanism, can play a role in the healing process of skin wounds. The ethanol extract of Moringa leaves was fractionated using petroleum ether and ethyl acetate. The MLEE (Moringa leaf ethanolic extract) gel formula was made to vary the extract weights in the order of 2%, 4% and 6% (b/b), while EFML (Moringa leaf ethyl acetate fraction) gel preparations were made to vary the extract weights in the order of 1%, 2% and 4% (b/b). Evaluation of the physical properties of the gel preparations, including organoleptic observation, homogenity tests, pH measurements, spreadability tests, adhesion tests, and antioxidant activity using the DPPH method. The physical properties of all preparation fulfill the requirements. The test for antioxidant gel MLEE IC50: MLEE 1 144.72 ± 3.52 ppm; MLEE 2 138.15 ± 0.93 ppm; MLEE 3 136.59 ± 1.68 ppm when compared to extracts IC50 MLEE 23.14 ppm (very strong antioxidant activity). The EFML gel formulation (IC50: EFML 1 208.81 ± 4.09 ppm; EFML 2 193.22 ± 2.53 ppm; EFML 3 182.48 ± 2.11 ppm) gave the same results when compared to the thick fraction of Moringa leaves, which has moderate antioxidant activity. The formula gel MLEE 3 has moderate antioxidant activity, which is the best gel formulation based on the results of physical properties test.
Standardisasi Parameter Spesifik Dan Non Spesifik Serbuk Kulit Jeruk Lemon (Citrus limon (L.) Osbeck) Nurfidiatun Ningsih; Ari Susiana Wulandari; Adhi Gunawan
INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal) Vol. 8 No. 2 (2024)
Publisher : Alma Ata University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21927/inpharnmed.v8i2.5138

Abstract

Jeruk Lemon (Citrus limon (L.) Osbeck) merupakan salah satu varietas jeruk lemon yang ditanam secara komersial di Indonesia. Kebanyakan limbah kulit jeruk lemon hanya dibuang begitu saja, tampa dimanfaatkan secara optimal. Untuk menangani masalah sampah, salah satu usaha yang sering dilakukan yaitu mengolah atau mendaur ulang sampah menjadi produk atau bahan yang berguna. Penelitian ini bertujuan untuk mengetahui apakah serbuk kulit jeruk lemon (KJL) (Citrus limon (L.) Osbeck) telah memenuhi standarisasi parameter spesifik dan non spesifik. Metode dalam penelitian ini menggunakan metode eksperimental laboratorium. Standarisasi yang dilakukan ada dua yaitu standarisasi spesifik dan non-spesifik. Standarisasi spesifik terdiri dari uji identitas, organoleptik, dan kadar senyawa larut air dan etanol. Standarisasi non spesifik meliputi uji susut pengeringan, kadar air, dan kadar abu. Hasil penelitian ini menunjukkan bahwa parameter spesifik organoleptis hasil berbentuk serbuk, warna kuning pucat, bau khas dan rasa pahit, penetapan senyawa larut air dengan hasil 9,3382% dan senyawa larut etanol dengan hasil 5,480%. Parameter non-spesifik didapatkan nilai rata-rata susut pengeringan 3,09 %, kadar air 6,26%, dan penetapan kadar abu 1,315%.
Pemberdayaan dan Peningkatan Pengetahuan Masyarakat melalui Tanaman Toga Seledri dan Sereh untuk Mencegah Hipertensi Sofiatus Saadah; Agung Yulian; Adhi Gunawan; Vikri Aulia; Susi Ramadanisudin; Anggi Defiana Sanjani; Esty Noor Aisyah; Alamanda Vinka Lantana; Dicki Patriansyah; Devy Mayang Anggraeni; Aris Munandar
Bangun Desa: Jurnal Pengabdian Masyarakat Vol. 4 No. 1 (2025)
Publisher : Universitas Alma Ata

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21927/jbd.2025.4(1).61-68

Abstract

Gaya hidup yang tidak sehat di masyarakat dapat menimbulkan berbagai macam penyakit seperti hipertensi, hiperkolesterol, diare dan lainnya. Tanaman obat keluarga (TOGA) dapat digunakan untuk meningkatkan kesehatan, mencegah dan pengobatan penyakit. Kegiatan ini bertujuan untuk meningkatkan pemahaman serta keterampilan masyarakat dalam memanfaatkan tanaman obat keluarga (TOGA), khususnya Sereh dan Seledri, sebagai upaya preventif dan alternatif pengobatan hipertensi menggunakan bahan alam. Kegiatan ini dilaksanakan pada tanggal 10 Februari 2025 dengan metode sosialisasi dan pelatihan budidaya serta pengolahan TOGA secara langsung kepada masyarakat. Banyaknya kasus hipertensi di Dusun Turi memerlukan penanganan yang dapat dimanfaatkan langsung oleh masyarakat selain obat sintesis yaitu dengan pemanfaatan TOGA . Hasilnya sebagian besar masyarakat dusun Turi, kelurahan Sidomulyo sangat antusias dalam mengikuti kegiatan ini serta menambah pengetahuan bagi masyarakat tentang pemanfaatan tanaman obat keluarga untuk mencegah penyakit hipertensi, masyarakat juga mendapatkan pengetahuan bagaimana cara membudidayakan dan pengolahan TOGA untuk penyakit hipertensi.
Co-Authors Agung Yulian Alamanda Vinka Lantana Anggi Defiana Sanjani Ari Susiana Wulandari Aris Munandar Depita Sucianingsih Devy Mayang Anggraeni Dicki Patriansyah Esty Noor Aisyah Fatmawati, Annisa Nurfidiatun Ningsih Riza Kurniawati Rizal Fauzi Sain Abrari Sofiatus Saadah Susi Ramadanisudin Vikri Aulia