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All Journal Indonesian Journal of Pharmaceutical Science and Technology SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Pharmaceutical Journal of Indonesia Jurnal Pengabdian Farmasi Malahayati (JPFM) Jurnal Pengabdian Kepada Masyarakat (Mediteg) Stannum : Jurnal Sains dan Terapan Kimia Jurnal Ilmiah Farmako Bahari Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang JPI (Jurnal Pendidikan Inklusi) INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal) TRANSFORMASI : JURNAL PENGABDIAN PADA MASYARAKAT Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Farmasi Klinik dan Sains Journal of Pharmaceutical and Sciences. Medical Sains : Jurnal Ilmiah Kefarmasian Masyarakat: Jurnal Pengabdian
Fatmawati, Annisa
Universitas Alma Ata
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Efek Antidiare Ekstrak Etanol Daun Kelor (Moringa oleifera L.) Pada Mencit Putih Jantan Fauzi, Rizal; Fatmawati, Annisa; Emelda, Emelda
Pharmaceutical Journal of Indonesia Vol 6, No 1 (2020)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2020.006.01.6

Abstract

Diare merupakan peningkatan frekuensi dan penurunan konsistensi feses bila dibandingkan dengan kondisi usus individu normal. Tingginya angka kejadian diare akut dan kronis mendorong para peneliti untuk terus berusaha dalam menemukan obat  sebagai antidiare baru, terutama yang berasal dari tanaman. Daun kelor (Moringa oleifera Lam) mengandung tanin yang merupakan senyawa polifenol dan berperan dalam proses antidiare. Penelitian ini bertujuan untuk mengetahui aktivitas ekstrak etanol daun kelor sebagai antidiare dengan melihat motilitas usus. Proses ekstraksi dilakukan dengan metode maserasi dengan menggunakan pelarut etanol 70%. Uji aktivitas antidiare dilakukan dengan metode transit intestinal dengan melihat perbandingan usus yang dilalui marker dengan panjang usus secara keseluruhan. Dari penelitian ini diketahui bahwa  nilai rata-rata rasio kelompok perlakuan lebih kecil dibandingkan dengan kelompok kontrol negatif (0,708).  Nilai rata-rata rasio  kelompok yang hewan mencit yang diberikan ekstrak etanol daun kelor (EEDK) dengan dosis 9,1 mg/20 g berat badan mencit adalah 0,664; kelompok dengan dosis EEDK 18,2 mg/20 g  berat badan mencit  sebesar 0,434 dan kelompok dengan dosis EEDK 36,4 mg/20 g  berat badan mencit  sebesar 0,389.  Dari nilai tersebut diketahui  ekstrak etanol daun kelor mempunyai efek antidiare melalui penghambatan motilitas usus. Efek ekstrak etanol daun kelor dalam menghambat motilitas usus paling baik pada pemberian dengan dosis 36,4 mg/20 g BB dengan nilai rata-rata rasio sebesar 0,389
PENYULUHAN APOTEKER TENTANG “PENCEGAHAN ALERGI DALAM KELUARGA DAN MASYARAKAT” DI DUSUN PASUTAN, DESA TRIRENGGO, BANTUL, DAERAH ISTIMEWA YOGYAKARTA Annisa Fatmawati
Jurnal Pengabdian Farmasi Malahayati (JPFM) Vol 4, No 2 (2021)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jpfm.v4i2.4938

Abstract

Perubahan pola kehidupan masyarakat modern membuat angka kejadian penyakit alergi semakin meningkat dari tahun ke tahun terutama kasus alergi pada anak. Di Indonesia berdasarkan sebuah penelitian yang dilakukan di kota Yogyakarta, terdapat prevalensi yang tinggi pada rhinitis alergi pada anak-anak usia sekolah dan pra sekolah. Oleh karena itu perlu adanya edukasi kepada masyarakat mengenai alergi, sehingga masyarakat dapat mengenali dan menangani resiko kejadian alergi dengan tepat. Berdasarkan informasi yang di peroleh, peserta kelompok PKK Dusun Pasutan, Desa Trirenggo, Kecamatan Bantul, DIY, belum pernah mendapatkan informasi tentang pencegahan alergi sehingga perlu dilakukan sosialisasi tentang pencegahan alergi dalam keluarga dan masyarakat. Kegiatan penyuluhan ini diharapkan peserta PKK (Pemberdayaan Kesejahteraan Keluarga) dapat membagikan informasi tentang pencegahan alergi, sehingga dapat meningkatkan kualitas kesehatan masyarakat. Metode yang digunakan dalam kegiatan ini adalah survei lokasi dan peserta, pelaksanaan sosialisasi dengan cara penyuluhan, diskusi interaktif, dan pambagian kuisioner. Kegiatan penyuluhan pencegahan alergi berjalan dengan lancar. Peserta yang hadir pada penyuluhan dari PKK Dusun Pasutan sebanyak 32 orang memahami tentang pencegahan alergi, secara signifikan hingga 100%. Para peserta yang hadir sangat antusias dalam mendengarkan penjelasan dan aktif bertanya terkait pencegahan dan rekomendasi terapi alergi. Kegiatan ini mendukung program Gerakan Masyarakat Hidup Sehat (GERMAS) bersama Ikatan Apoteker Indonesia (IAI) Kabupaten Bantul.
SOSIALISASI PEMBUATAN JAMU KEKINIAN DAN JAMU INSTAN DI DUSUN KADIBESO, ARGODADI, SEDAYU, BANTUL, DIY Annisa Fatmawati
Jurnal Pengabdian Kepada Masyarakat (MEDITEG) Vol 6 No 2 (2021): Jurnal Pengabdian Kepada Masyarakat (MEDITEG)
Publisher : Pusat Penelitian dan Pengabdian Kepada Masyarakat (P3M) Politeknik Negeri Tanah Laut (Politala)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34128/mediteg.v6i2.95

Abstract

The people in Kadibeso Hamlet, Argodadi Village, Sedayu, Bantul, have never received socialization and training on making instant herbal medicine. The methods used in conducting the socialization and workshop on making instant herbal medicine to the people of Dusun Kadibeso: counseling on "Utilizing TOGA" and a demonstration on how to make a "contemporary" drink from turmeric juice (Curcuma longa Linn) mixed with milk, as well as making instant ginger (Zingiber officinale). The results of interviews and distribution of questionnaires after the socialization and workshop on making herbal medicine “Curmilk”, all participants understood the material given with a 100% understanding percentage. Traditional herbal medicine in liquid form has the disadvantage that it is not durable, because it is easily overgrown by bacteria and fungi. So, the innovation of making instant ginger powder “provides a solution”, so that herbal preparations can be stored longer and can become a commodity for traditional medicinal products. Jamu which is packaged in the form of today's products is an opportunity to elevate traditional Indonesian medicines into superior products that are beneficial to health.
Microscopic Identification and Determination of Total Flavonoid Content of Moringa Leaves Extract and Ethyl Acetate Fraction (Moringa oleifera L.) Annisa Fatmawati; Depita Sucianingsih; Riza Kurniawati; Muhammad Abdurrahman
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 3, No. 1 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v1i1.36337

Abstract

This research was conducted to identify simplicia microscopically, phytochemical screening and determination of total flavonoid content of extract and ethyl acetate fraction from Moringa (Moringa oleifera L.) leaves using UV-Visible Spectrophotometry method. The experimental design used in this study was to perform microscopic identification of Moringa leaf powder simplicia, make 96% and 70% ethanol extract and ethyl acetate fraction of Moringa leaves from 70% ethanol extract, then carry out phytochemical screening and determination of total flavonoid content with quercetin standards. Phytochemical screening on the ethyl acetate fraction of Moringa leaves included tests for the content of flavonoids, saponins, tannins and alkaloids. The results of microscopic identification of Moringa leaf simplicia showed the presence of calcium oxalate crystals in the form of rosettes, mesophyll and stomata. The result of determination of total flavonoid content in 96% ethanol extract was 16.69 ± 0.74% (w/w), 70% ethanol extract was 10.84 ± 0.49% (w/w), Moringa leaf ethyl acetate fraction 14 .45 ± 0.90% (w/w). The highest total flavonoid content was found in the 96% ethanol extract of Moringa leaves in accordance with the 2017 Indonesian Herbal Pharmacopoeia, that the thick extract of Moringa leaves containing no less than 6.30% (w/w) total flavonoids was calculated as quercetin.
FORMULATION, EVALUATION OF PHYSICAL PROPERTIES AND ANTIOXIDANT ACTIVITY OF ETHANOL EXTRACT AND ETHYL ACETATE FRACTION GEL OF Moringa oleifera LEAVES Annisa Fatmawati; Rizal Fauzi; Adhi Gunawan; Riza Kurniawati; Depita Sucianingsih; Sain Abrari
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 7 No 4 (2022)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v7i4.433

Abstract

The leaves of Moringa (Moringa oleifera Lam) contain quercetin, a flavonoid that plays a role in the skin regeneration process with an antioxidant mechanism, can play a role in the healing process of skin wounds. The ethanol extract of Moringa leaves was fractionated using petroleum ether and ethyl acetate. The MLEE (Moringa leaf ethanolic extract) gel formula was made to vary the extract weights in the order of 2%, 4% and 6% (b/b), while EFML (Moringa leaf ethyl acetate fraction) gel preparations were made to vary the extract weights in the order of 1%, 2% and 4% (b/b). Evaluation of the physical properties of the gel preparations, including organoleptic observation, homogenity tests, pH measurements, spreadability tests, adhesion tests, and antioxidant activity using the DPPH method. The physical properties of all preparation fulfill the requirements. The test for antioxidant gel MLEE IC50: MLEE 1 144.72 ± 3.52 ppm; MLEE 2 138.15 ± 0.93 ppm; MLEE 3 136.59 ± 1.68 ppm when compared to extracts IC50 MLEE 23.14 ppm (very strong antioxidant activity). The EFML gel formulation (IC50: EFML 1 208.81 ± 4.09 ppm; EFML 2 193.22 ± 2.53 ppm; EFML 3 182.48 ± 2.11 ppm) gave the same results when compared to the thick fraction of Moringa leaves, which has moderate antioxidant activity. The formula gel MLEE 3 has moderate antioxidant activity, which is the best gel formulation based on the results of physical properties test.
FORMULATION, EVALUATION OF PHYSICAL PROPERTIES AND ANTIOXIDANT ACTIVITY OF ETHANOL EXTRACT AND ETHYL ACETATE FRACTION GEL OF Moringa oleifera LEAVES Annisa Fatmawati; Rizal Fauzi; Adhi Gunawan; Riza Kurniawati; Depita Sucianingsih; Sain Abrari
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 7 No 4 (2022)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v7i4.433

Abstract

The leaves of Moringa (Moringa oleifera Lam) contain quercetin, a flavonoid that plays a role in the skin regeneration process with an antioxidant mechanism, can play a role in the healing process of skin wounds. The ethanol extract of Moringa leaves was fractionated using petroleum ether and ethyl acetate. The MLEE (Moringa leaf ethanolic extract) gel formula was made to vary the extract weights in the order of 2%, 4% and 6% (b/b), while EFML (Moringa leaf ethyl acetate fraction) gel preparations were made to vary the extract weights in the order of 1%, 2% and 4% (b/b). Evaluation of the physical properties of the gel preparations, including organoleptic observation, homogenity tests, pH measurements, spreadability tests, adhesion tests, and antioxidant activity using the DPPH method. The physical properties of all preparation fulfill the requirements. The test for antioxidant gel MLEE IC50: MLEE 1 144.72 ± 3.52 ppm; MLEE 2 138.15 ± 0.93 ppm; MLEE 3 136.59 ± 1.68 ppm when compared to extracts IC50 MLEE 23.14 ppm (very strong antioxidant activity). The EFML gel formulation (IC50: EFML 1 208.81 ± 4.09 ppm; EFML 2 193.22 ± 2.53 ppm; EFML 3 182.48 ± 2.11 ppm) gave the same results when compared to the thick fraction of Moringa leaves, which has moderate antioxidant activity. The formula gel MLEE 3 has moderate antioxidant activity, which is the best gel formulation based on the results of physical properties test.
FORMULASI SEDIAAN TABLET EKSTRAK ETANOL DAUN SEMBUNG RAMBAT (Mikania micrantha) SEBAGAI ANTIDIARE SERTA PENGUJIAN KANDUNGAN FLAVONOID TOTAL Aslam, M.Muzhil; Estiningsih, Daru; Fatmawati, Annisa
Jurnal Ilmiah Farmako Bahari Vol 15, No 2 (2024): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v15i2.3044

Abstract

Prevalensi diare di Indonesia menurut Riskesdas 2018 diperkirakan 9% pada usia kurang dari 1 tahun , 11,5% usia 1 sampai 4 tahun, 6,2% usia 5 sampai 14 tahun, dan 6,7% berusia 15 sampai 24 tahun. Flavonoid pada daun M.micrantha memiliki aktivitas antidiare dengan menghambat motilitas usus. Tujuan penelitian ini adalah untuk mengetahui perbedaan sifat fisik tablet EEDSR 96% dengan beberapa variasi komposisi bahan pengisi (laktosa, amilum, kalium fosfat) dan mengetahui perbedaan nilai kadar flavonoid total yang terkandung di dalamnya. Jenis penelitian ini eksperimental menggunakan metode spektrofotometri UV Vis. Evaluasi sifat fisik tablet ekstrak etanol daun sembung rambat (EEDSR) 96% meliputi keseragaman bobot tablet, keseragaman ukuran, kekerasan, kerapuhan dan waktu hancur tablet. Uji kadar flavonoid total menggunakan metode spektrofotometri UV-Vis pada sediaan tablet dan kuersetin sebagai pembanding. Hasil: Evaluasi sifat fisik tablet EEDSR 96% dari uji granul dan sifat fisik tablet memenuhi persyaratan. Kadar flavonoid total pada tablet EEDSR 96%, formula I, II dan III adalah 1,37±0,04 mgEQ/100mg, 1,61 ± 0,03 mgEQ/100mg, dan 1,58 ± 0,02 mgEQ/100mg. Kesimpulan: Tablet dengan variasi komposisi bahan pengisi memiliki sifat fisik yang berbeda bermakna pada parameter waktu hancur dan kadar total flavonoid total. Kadar flavonoid total pada masing-masing formula tablet EEDSR 96% diperoleh nilai rata-rata yang berbeda makna.
SOSIALISASI PEMBUATAN JAMU KEKINIAN DAN JAMU INSTAN DI DUSUN KADIBESO, ARGODADI, SEDAYU, BANTUL, DIY Fatmawati, Annisa
Jurnal Pengabdian Kepada Masyarakat (MEDITEG) Vol. 6 No. 2 (2021): Jurnal Pengabdian Kepada Masyarakat (MEDITEG)
Publisher : Pusat Penelitian dan Pengabdian Kepada Masyarakat (P3M) Politeknik Negeri Tanah Laut (Politala)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34128/mediteg.v6i2.95

Abstract

The people in Kadibeso Hamlet, Argodadi Village, Sedayu, Bantul, have never received socialization and training on making instant herbal medicine. The methods used in conducting the socialization and workshop on making instant herbal medicine to the people of Dusun Kadibeso: counseling on "Utilizing TOGA" and a demonstration on how to make a "contemporary" drink from turmeric juice (Curcuma longa Linn) mixed with milk, as well as making instant ginger (Zingiber officinale). The results of interviews and distribution of questionnaires after the socialization and workshop on making herbal medicine “Curmilk”, all participants understood the material given with a 100% understanding percentage. Traditional herbal medicine in liquid form has the disadvantage that it is not durable, because it is easily overgrown by bacteria and fungi. So, the innovation of making instant ginger powder “provides a solution”, so that herbal preparations can be stored longer and can become a commodity for traditional medicinal products. Jamu which is packaged in the form of today's products is an opportunity to elevate traditional Indonesian medicines into superior products that are beneficial to health.
Inhibition Activity Of Ethanolic Extract Of Ulva lactuca Against Staphylococcus aureus emelda, emelda; Safitri, Eka Asriani; Fatmawati, Annisa
Pharmaceutical Journal of Indonesia Vol. 7 No. 1 (2021)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2021.007.01.7

Abstract

Staphylococcus aureus (S. aureus) is a normal flora that can cause mild skin infections, one of which is acne. Commonly used chemical treatments are antibiotics such as Clindamycin. Continuous use of antibiotics can lead to resistance. Natural ingredients that are possible can inhibit the growth of bacteria. Treatment caused by S.aureus is Ulva lactuca Linn. (Green algae). This marine biota contains compounds that have the potential to be antibacterial, including triterpenoids, flavonoids, and saponins. This study aims to compare antibacterial activity of  ethanolic extract of Ulva lactuca and Clindamycin against S. aureus bacteria. This type of research is an experimental laboratory. Ulva lactuca was extracted by maceration method using ethanol 96% solvent. Then carried out testing for antibacterial activity using the agar diffusion method by sump technique. The study was divided into 6 groups. One Clindamycin group and 5 treatment groups respectively with extract concentrations of 20%, 40%, 60%, 80%, and 100%. The test was carried out in 3 repetitions. Data analysis was processed by SPSS using the Kruskal-Wallis test to determine which groups had difference. The results showed that the ethanolic extract of Ulva lactuca was able to inhibit the growth of S. aureus bacteria with strong categories at concentrations of 20%, 40%, and 60%. Very strong category at 80% and 100% concentrations. The 100% concentration had the largest average inhibition zone diameter of 22 ± 0.577 mm which was not significantly different from Clindamycin with a significance value of 0.043 (p <0.05). This study concludes that the ethanolic extract of Ulva lactuca has activity in inhibiting the growth of S.aureus bacteria with strong to very strong categories, but statistically not as strong as Clindamycin
Inhibition Activity Of Ethanolic Extract Of Ulva lactuca Against Staphylococcus aureus emelda, emelda; Safitri, Eka Asriani; Fatmawati, Annisa
Pharmaceutical Journal of Indonesia Vol. 7 No. 1 (2021)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2021.007.01.7

Abstract

Staphylococcus aureus (S. aureus) is a normal flora that can cause mild skin infections, one of which is acne. Commonly used chemical treatments are antibiotics such as Clindamycin. Continuous use of antibiotics can lead to resistance. Natural ingredients that are possible can inhibit the growth of bacteria. Treatment caused by S.aureus is Ulva lactuca Linn. (Green algae). This marine biota contains compounds that have the potential to be antibacterial, including triterpenoids, flavonoids, and saponins. This study aims to compare antibacterial activity of  ethanolic extract of Ulva lactuca and Clindamycin against S. aureus bacteria. This type of research is an experimental laboratory. Ulva lactuca was extracted by maceration method using ethanol 96% solvent. Then carried out testing for antibacterial activity using the agar diffusion method by sump technique. The study was divided into 6 groups. One Clindamycin group and 5 treatment groups respectively with extract concentrations of 20%, 40%, 60%, 80%, and 100%. The test was carried out in 3 repetitions. Data analysis was processed by SPSS using the Kruskal-Wallis test to determine which groups had difference. The results showed that the ethanolic extract of Ulva lactuca was able to inhibit the growth of S. aureus bacteria with strong categories at concentrations of 20%, 40%, and 60%. Very strong category at 80% and 100% concentrations. The 100% concentration had the largest average inhibition zone diameter of 22 ± 0.577 mm which was not significantly different from Clindamycin with a significance value of 0.043 (p <0.05). This study concludes that the ethanolic extract of Ulva lactuca has activity in inhibiting the growth of S.aureus bacteria with strong to very strong categories, but statistically not as strong as Clindamycin
Co-Authors Adelia, Melina Freda Adhi Gunawan Akbar, Jasmine Aulia Anisa Tri Hutami Aprilia, Veriani Ariski, Denis Ashari, Ayu - Aslam, M.Muzhil Asrori, Moh Astuti, Eka Dyah Ayu Bachri, Moch. Saiful Bahun, Nur Rohma Inayah Depita Sucianingsih Depita Sucianingsih Elvana, Azza emelda, emelda Emelda, Emelda Estiningsih, Daru Fauzi, Rizal Gerriandi, Aqila Aqhnia Gunawan, Adhi Hanifah, Wening Iswahjuni, Iswahjuni Jannah, Nurul Juliana, Intan Lahardo, Devanus Lestari, Yessi Manusu, Abd Sukri S Mastamah, Mastamah Muhammad Abdurrahman Muhammad Abdurrahman Munir Mulyaningsih, Sundari Munir, Muhammad Abdurrahman Nadia, Melta Ainun Nugroho, Novreza Avistha Nurhidayanti, Nurhidayanti Nurinda, Eva Nurinda, Eva Purbiastuti, Putri Ayu Puspitasari, Ade Putri, Imram Radne Rimba Putri, Nindya Tresiana Rahmadani, Andini Putri Rahmawati, Feti Ramadhani, Firmansyah Ardian Rendani, Ike Peny Riza Kurniawati Riza Kurniawati Rizal Fauzi Rizal Fauzi Safitri, Eka Asriani Sain Abrari Sarwadhamana, Raden Jaka Sati, Eva Laras Septiandi, Baiq Husnul Hotima Solikah, Wahyu Yuliana Sri Suprapti Suci Rahmawati, Suci Sucianingsih, Depita Suciati Suciati Tjandra, Edbert Rafael Veronika, Nabela Wijayanti, Galuh Candra Wiwied Ekasari Wulandari, Ari Susiana Yuliana, Khalifah Zendrato, Mei Albert Zuliyati, Isti Chana