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Analisis Faktor Resiko Sepsis Neonatal terhadap Clinical Outcome di Neonatal Intensive Care Unit (NICU) Rizal Fauzi; Titik Nuryastuti; Ika Puspitasari
Indonesian Journal of Hospital Administration Vol 3, No 2 (2020)
Publisher : Universitas Alma Ata

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21927/ijhaa.2020.3(2).86-93

Abstract

 AbstrakSepsis neonatal merupakan sindrom klinik yang terjadi secara sistemik dari penyakit infeksi yang terjadi pada 4 minggu pertama kehidupan. Sepsis neonatal merupakan urutan ketiga penyebab kematian neonatal, setelah kelahiran prematur dan komplikasi terkait intrapartum (atau asfiksia). Kejadian sepsis neonatal dapat diamati pada bayi yang dilahirkan dengan asfiksia, prematuritas, berat badan lahir rendah, dan faktor-faktor lainnya seperti jenis persalinan, perawatan antenatal yang diterima, pemberian makanan campuran untuk bayi baru lahir, dan perawatan tali pusat diyakini berkontribusi pada insidensi sepsis neonatal. Tujuan dari penelitian ini adalah untuk mengetahui hubungan antar faktor resiko terjadinya sepsis neonatal yang dirawat di Neonatal Intensive Care Unit (NICU) RSUP Dr. Sardjito Yogyakarta dengan clinical outcome pasien. Penelitian ini merupakan observasional deskriptif dengan desain cohort retrospective. Data dari rekam medis pasien terdiagnosis sepsis neonatal di Neonatal Intensive Care Unit (NICU) RSUP DR.Sardjito Yogyakarta pada periode 1 Januari – 31 Desember 2015. Data yang memenuhi kriteria inklusi dikumpulkan dan dicatat, kemudian data dianalisis dengan menggunakan analisis bivariat untuk melihat hubungan variabel penelitian dengan clinical oucome. Analisis yang digunakan adalah uji statistik Chi-Square-fisher. Hasil penelitian ini diketahui sepsis neonatus banyak dialami pasien dengan jenis kelamin laki-laki 58,73%; berat badan lahir ≤ 2.500 gram 73,02%; lama perawatan lebih dari 15 hari 55,56%. Hasil uji analisis bivariat uji Chi square-fisher secara statistik tidak terdapat hubungan antara jenis kelamin dengan clinical outcome (p = 0,695), berat badan lahir dengan clinical outcome (p=0,070), lama rawat inap dengan clinical outcome (p=0,305), infeksi penyerta dengan clinical outcome (p=0,223) dan asfiksia dengan clinical outcome (p=0,559) Kata Kunci: Sepsis neonatal; NICU; Clinical outcome
FORMULATION, EVALUATION OF PHYSICAL PROPERTIES AND ANTIOXIDANT ACTIVITY OF ETHANOL EXTRACT AND ETHYL ACETATE FRACTION GEL OF Moringa oleifera LEAVES Annisa Fatmawati; Rizal Fauzi; Adhi Gunawan; Riza Kurniawati; Depita Sucianingsih; Sain Abrari
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 7 No 4 (2022)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v7i4.433

Abstract

The leaves of Moringa (Moringa oleifera Lam) contain quercetin, a flavonoid that plays a role in the skin regeneration process with an antioxidant mechanism, can play a role in the healing process of skin wounds. The ethanol extract of Moringa leaves was fractionated using petroleum ether and ethyl acetate. The MLEE (Moringa leaf ethanolic extract) gel formula was made to vary the extract weights in the order of 2%, 4% and 6% (b/b), while EFML (Moringa leaf ethyl acetate fraction) gel preparations were made to vary the extract weights in the order of 1%, 2% and 4% (b/b). Evaluation of the physical properties of the gel preparations, including organoleptic observation, homogenity tests, pH measurements, spreadability tests, adhesion tests, and antioxidant activity using the DPPH method. The physical properties of all preparation fulfill the requirements. The test for antioxidant gel MLEE IC50: MLEE 1 144.72 ± 3.52 ppm; MLEE 2 138.15 ± 0.93 ppm; MLEE 3 136.59 ± 1.68 ppm when compared to extracts IC50 MLEE 23.14 ppm (very strong antioxidant activity). The EFML gel formulation (IC50: EFML 1 208.81 ± 4.09 ppm; EFML 2 193.22 ± 2.53 ppm; EFML 3 182.48 ± 2.11 ppm) gave the same results when compared to the thick fraction of Moringa leaves, which has moderate antioxidant activity. The formula gel MLEE 3 has moderate antioxidant activity, which is the best gel formulation based on the results of physical properties test.
Pembentukan Duta Remaja Cegah Stunting di Kabupaten Magelang: Establishment of Youth Ambassador to Prevent Stunting in Magelang Regency Ika Mustika Dewi; Rizal Fauzi; Pramitha Sari; Sofyan Indrayana; Raden Jaka Sarwadhamana; Siti Nurunniyah; Natalia Desy Putriningtyas
Jurnal Pengabdian Kepada Masyarakat: Kesehatan Vol. 3 No. 2 (2023): Juli
Publisher : Sekolah Tinggi Ilmu Kesehatan Notokusumo Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Abstrak: Stunting merupakan permasalahan kesehataan anak di Indonesia yang perlu diperhatikan. Berbagai upaya dilakukan dalam upaya percepatan penurunan stunting di Indonesia. Kabupaten Magelang merupakan satu kabupaten yang telah ditetapkan sebagai wilayah prioritas percepatan penurunan stunting. Tujuan pengabdian kepada masyarakat ini untuk meningkatkan partisipasi masyarakat yaitu remaja dalam rangka pencegahan stunting sejak dini. Metode yang digunakan yaitu pendidikan kesehatan dengan ceramah dan demonstrasi. Kegiatan pembentukan duta remaja cegah stunting ini diikuti oleh 20 orang remaja dari 10 kecamatan di Kabupaten Magelang. Setelah dilakukan pendidikan kesehatan ini didapatkan adanya peningkatan pengetahuan dan keterampilan remaja dan berhasil ditunjuk sepasang remaja duta cegah stunting kabupaten magelang. Dengan demikian diharapkan peran serta dari duta remaja tersebut untuk edukasi pada teman sebaya mengenai penceghan stunting   Abstract: Stunting is a child health problem in Indonesia that needs attention. Various efforts have been made to accelerate the reduction of stunting in Indonesia. Magelang Regency is one of the districts that has been designated as a priority area for the acceleration of stunting reduction. The purpose of this community service is to increase community participation, namely youth, in the context of preventing stunting from an early age. The method used is health education with lectures and demonstrations. The activity to form youth ambassadors to prevent stunting was attended by 20 teenagers from 10 sub-districts in Magelang Regency. After carrying out this health education, it was found that there was an increase in the knowledge and skills of adolescents and a pair of young ambassadors for preventing stunting in Magelang district were successfully appointed. Thus it is hoped that the role of the youth ambassadors will be to educate peers about stunting prevention.
FORMULATION, EVALUATION OF PHYSICAL PROPERTIES AND ANTIOXIDANT ACTIVITY OF ETHANOL EXTRACT AND ETHYL ACETATE FRACTION GEL OF Moringa oleifera LEAVES Annisa Fatmawati; Rizal Fauzi; Adhi Gunawan; Riza Kurniawati; Depita Sucianingsih; Sain Abrari
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 7 No 4 (2022)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v7i4.433

Abstract

The leaves of Moringa (Moringa oleifera Lam) contain quercetin, a flavonoid that plays a role in the skin regeneration process with an antioxidant mechanism, can play a role in the healing process of skin wounds. The ethanol extract of Moringa leaves was fractionated using petroleum ether and ethyl acetate. The MLEE (Moringa leaf ethanolic extract) gel formula was made to vary the extract weights in the order of 2%, 4% and 6% (b/b), while EFML (Moringa leaf ethyl acetate fraction) gel preparations were made to vary the extract weights in the order of 1%, 2% and 4% (b/b). Evaluation of the physical properties of the gel preparations, including organoleptic observation, homogenity tests, pH measurements, spreadability tests, adhesion tests, and antioxidant activity using the DPPH method. The physical properties of all preparation fulfill the requirements. The test for antioxidant gel MLEE IC50: MLEE 1 144.72 ± 3.52 ppm; MLEE 2 138.15 ± 0.93 ppm; MLEE 3 136.59 ± 1.68 ppm when compared to extracts IC50 MLEE 23.14 ppm (very strong antioxidant activity). The EFML gel formulation (IC50: EFML 1 208.81 ± 4.09 ppm; EFML 2 193.22 ± 2.53 ppm; EFML 3 182.48 ± 2.11 ppm) gave the same results when compared to the thick fraction of Moringa leaves, which has moderate antioxidant activity. The formula gel MLEE 3 has moderate antioxidant activity, which is the best gel formulation based on the results of physical properties test.