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p-Index From 2021 - 2026
0.444
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All Journal International Journal of Health and Pharmaceutical (IJHP) Folia Medica Indonesiana
Rachmi Kurniawati, Rachmi
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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Effect of Moringa Flower Extract (Moringa Oleifera) on Collagenization and Histopathology of Skin Tissue in the Healing of Dermapen Scars in Obese Male Wistar White Rats Soraya Tanjung, Dian; Kurniawati, Rachmi; Adi Mylano, Tri
International Journal of Health and Pharmaceutical (IJHP) Vol. 4 No. 2 (2024): May 2024
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v4i2.318

Abstract

Injury can be accidental, intentional, or disease-related. Moringa leaves may help heal wounds. The research aims to test and assess the effects of Moringa oleifera flower extract on dermapen wound healing collagenization in male Wistar strain white rats, an obese model, and their histological findings—quantitative True Experimental Study with Post-Test Only Control Group Design. Twenty-four male Wistar white rats (Rattus norvegicus) were sampled. Accumulation of Test Animals, Moringa Flower Extract Preparation, Phytochemical Screening / Secondary Metabolite Test, Treatment Process (200, 400, and mg/kgBW of Moringa flower extract), Wound Observation, Histopathological Skin Preparations, and Histopathological Examination of Preparations were the research procedures. Window data was analyzed using SPSS 25.0 and One Way ANOVA with a 95% confidence level (p < 0.05). The Post Hoc Test with LSD was used for further analysis. The research results found Moringa flower extract at 200mg/Kg BW, 400mg/KgBW, and 600mg/KgBW could expedite wound healing and improve collagen density in obese mice's dermapen wounds. The 600mg dose was most beneficial. Research conclusions: Moringa flower extract aids dermapen wound healing, collagenization, and obesity weight loss, according to a study.
Relationship between High Sensitivity-C Reactive Protein Level and Impaired Cognitive Function in HIV Patients Kurniawati, Rachmi; Sugianto, Paulus
Folia Medica Indonesiana Vol. 57, No. 1
Publisher : Folia Medica Indonesiana

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Abstract

Human Immunodeficiency Virus (HIV) infection was one of the most serious health challenges in the world. The Ministry of Health of the Republic of Indonesia reports the number of HIV cases in Indonesia as of June 2019 as many as 349,882. At present, although antiretroviral combination therapy has been found, the prevalence of neurocognitive disorders in the form of HIV-associated neurocognitive disorders (HAND) reaches 50% of HIV patients. This study aimed to determine the relationship between high sensitivity-C Reactive Protein (hs-CRP) level and cognitive impairment assessed using MoCA-INA score in HIV patients at the UPIPI Dr. Soetomo Academic Hospital Surabaya. This cross-sectional study used consecutive sampling that fulfilled inclusion and exclusion criteria. The cognitive function of the subjects was examined by MoCA-INA score and blood samples were collected for measuring hs-CRP level. Of 100 subjects, 41 had abnormal MoCA-INA score and 59 had normal score. The number of subjects with high level of hs-CRP (>= 5) who had abnormal and normal MoCA-INA score were 22 (53,7%) and 6 (10,2%) respectively. This result was significantly difference with p = 0,0001, RO = 28,072 (95% CI, 5,470-144,052). Therefore, there was a significant relationship between hs-CRP level and cognitive function, where a subject with a high hs-CRP level was more likely to have impaired cognitive function.
Co-Authors Adi Mylano, Tri Paulus Sugianto, Paulus Soraya Tanjung, Dian