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All Journal Jurnal Biosains Pascasarjana Klinikal Sains (Jurnal Analis Kesehatan) PROFESSIONAL HEALTH JOURNAL
Mutia Hariani Nurjanah
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing

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RELATIONSHIP BETWEEN HbA1C AND eGFR IN DIABETES MELLITUS (DM) PATIENTS FOLLOWING PROLANIS AT ULTRA MEDICA TULUNGAGUNG CLINIC LABORATORY taufik salis syaifuddin; Mutia Hariani Nurjanah; Nurul Chamidah Kumalasari; Wimbuh Tri widodo
Jurnal Biosains Pascasarjana Vol. 24 No. 1SP (2022): JURNAL BIOSAINS PASCASARJANA: SPECIAL ISSUE
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v24i1SP.2022.13-20

Abstract

Diabetes mellitus is a condition of abnormal blood glucose metabolism characterized by prolonged hyperglycemia and elevated HbA1c levels as a standard test for diabetes mellitus. HbA1c describes the level of sugar in the blood for the last 3 months. One of the complications of diabetes mellitus is kidney damage. The state of kidney function can be described from the GFR (Glomerular Filtration Rate) examination as a standard examination for abnormalities in kidney disease. The purpose of this study was to determine the relationship between HbA1c levels and eGFR values ​​in people with diabetes mellitus. The design of this study was a cross-sectional approach to 30 samples of DM patients who took Prolanis at the Ultra Medica Tulungagung Clinical Laboratory. The results showed that the average HbA1c level in all samples was 6.2% and the average eGFR value was 88.7 ml/min/1, 73m2. The Pearson correlation test obtained a ρ value = 0.000 so that it can be concluded that there is a relationship between HbA1c levels and eGFR values ​​in people with diabetes mellitus who take Prolanis at the Ultra Medica Clinical Laboratory Tulungagung.
Identification of Antibacterial Compounds in Methanol Extract of Clove Stems (Syzygium aromaticum) using Liquid Chromatography Mass Spectrometry Yunita Diyah Safitri; Rahma Diyan Martha; Mutia Hariani Nurjanah
PROFESSIONAL HEALTH JOURNAL Vol. 6 No. 2 (2025): In Progress issue
Publisher : Pusat Penelitian dan Pengabdian Masyarakat (PPPM) STIKES Banyuwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54832/phj.v6i2.897

Abstract

Introduction: Clove is well-known as an herbal plant that is also included in the spice group which is known to have an antibacterial activity spread across the stems, leaves, and flowers. Objectives: The purpose of this study was to identify the antibacterial compounds that are found in the methanol extract of clove stems and the antibacterial activity of clove stem extract against Bacillus cereus. Methods: We used Liquid Chromatography Mass Spectrometry (LC-MS) method to identify the antibacterial compounds, and used the paper disc method (Kirby Bauer) for antibacterial test with clove stem extract concentrations of 30%, 50%, and 70%, positive control of Amoxicillin at a dose of 0.5 mg/ml, also a negative control of sterile aquadest. Results: The results showed four antibacterial compounds in the extract, namely (+)-Licarin A, 4-O-Caffeoylquinic acid_1, Eckol, and Leucodelphinidin. Methanol extract of clove stems at the concentrations of 30%, 50%, and 70% inhibited the growth of Bacillus cereus significantly (p <0.05). The concentration of 30% was categorized as quite sensitive, meanwhile, both 50% and 70% were categorized as sensitive. Conclusions: In conclusion, four compounds with antibacterial properties were found in the methanol extract of clove stems based on LCMS analysis, and supported by the results of antibacterial tests which showed the formation of an inhibition zone in the clove stem extract against the growth of Bacillus cereus.
Identification of Antibacterial Compounds in Methanol Extract of Clove Stems (Syzygium aromaticum) using Liquid Chromatography Mass Spectrometry Yunita Diyah Safitri; Rahma Diyan Martha; Mutia Hariani Nurjanah
PROFESSIONAL HEALTH JOURNAL Vol. 6 No. 2 (2025): June
Publisher : Pusat Penelitian dan Pengabdian Masyarakat (PPPM) STIKES Banyuwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54832/phj.v6i2.897

Abstract

Introduction: Clove is well-known as an herbal plant that is also included in the spice group which is known to have an antibacterial activity spread across the stems, leaves, and flowers. Objectives: The purpose of this study was to identify the antibacterial compounds that are found in the methanol extract of clove stems and the antibacterial activity of clove stem extract against Bacillus cereus. Methods: We used Liquid Chromatography Mass Spectrometry (LC-MS) method to identify the antibacterial compounds, and used the paper disc method (Kirby Bauer) for antibacterial test with clove stem extract concentrations of 30%, 50%, and 70%, positive control of Amoxicillin at a dose of 0.5 mg/ml, also a negative control of sterile aquadest. Results: The results showed four antibacterial compounds in the extract, namely (+)-Licarin A, 4-O-Caffeoylquinic acid_1, Eckol, and Leucodelphinidin. Methanol extract of clove stems at the concentrations of 30%, 50%, and 70% inhibited the growth of Bacillus cereus significantly (p <0.05). The concentration of 30% was categorized as quite sensitive, meanwhile, both 50% and 70% were categorized as sensitive. Conclusions: In conclusion, four compounds with antibacterial properties were found in the methanol extract of clove stems based on LCMS analysis, and supported by the results of antibacterial tests which showed the formation of an inhibition zone in the clove stem extract against the growth of Bacillus cereus.
UJI ANTIMIKROBA EKSTRAK DAUN CIPLUKAN (Physalis angulata L.) TERHADAP PERTUMBUHAN BAKTERI Streptococcus pyogenes Anas Fadli Wijaya; Rian Anggia Destiawan; Ayu Tri Agustin; Hartalina Mufidah; Mutia Hariani Nurjanah
Klinikal Sains : Jurnal Analis Kesehatan Vol. 12 No. 2 (2024): Desember
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/klinikal_sains.v12i2.5282

Abstract

Infectious diseases caused by microbes in Indonesia are mostly due to bacterial infections. One of the bacteria responsible is Streptococcus pyogenes, which causes Acute Respiratory Infections. Treatment of infections caused by S. pyogenes mostly involves the use of antibiotics. In some cases, antibiotics often lead to resistance, necessitating alternative solutions, such as antimicrobial compounds derived from natural sources like flavonoids, one of which can be found in the extract of ground cherry leaf (Physalis angulata L.). The aim of this study is to investigate the antibacterial effects of a 70% ethanol extract of ground cherry leaves on the growth of S. pyogenes. This research is an experimental laboratory study using a post-test control group design only. The determination of antimicrobial activity was carried out using the well diffusion method. The ground cherry leaf extract, diluted with 10% DMSO, was pipetted into the wells. The positive control used chloramphenicol, while the negative control used 10% DMSO. Based on the observations, an inhibition zone was formed in the positive control with an average of 26.18 ± 1.88 mm, treatment 1 with 100% ground cherry leaf extract 16.22 ± 1.33 mm, treatment 2 with 50% ciplukan leaf extract 15.09 ± 1.01 mm, and treatment 3 with 25% ground cherry leaf extract 12.85 ± 0.87 mm.
Co-Authors Agustin, Ayu Tri Anas Fadli Wijaya Hartalina Mufidah Nurul Chamidah Kumalasari Rahma Diyan Martha Rian Anggia Destiawan Safitri, Yunita Diyah taufik salis syaifuddin Wimbuh Tri Widodo