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All Journal Jurnal Penelitian Farmasi Indonesia JOPS (Journal Of Pharmacy and Science) Jurnal Farmasi Indonesia Journal of Pharmascience
nesa agistia
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Journal : Journal of Pharmascience

 1 
OPTIMASI DAN UJI AKTIFITAS ANTIOKSIDAN FORMULA TONER MINYAK DAUN SIRIH HIJAU (Piper betle L.) Nesa Agistia; Benni Iskandar; Nofriyanti Nofriyanti
Journal of Pharmascience Vol. 13 No. 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.23886

Abstract

Exposure to free radicals can damage the skin. Green betel leaf oil, which has antioxidant activity, can be formulated into a toner. This study aimed to determine the optimal toner formula and  to evaluate its antioxidant activity. Optimization was performed using a factorial design with two factors: Tween 80 and PEG 400 concentrations. The optimum formula, determined with Design Expert 13, consisted of 10% Tween 80 and 5% PEG 400, with a predicted pH of 5.66 and 99% transmittance. Validation using a One-Sample T-Test showed no significant difference (p > 0.05) between the predicted and actual results. The optimized toner had a pH of 5.69, a transmittance of 99.2%, a particle size of 12.2 nm, and very strong antioxidant activity (IC50 = 43.29 µg/mL). In this research, an optimum toner formula was obtained which has good physical properties and very strong antioxidant activity. 
Co-Authors BENNI ISKANDAR Muhtadi, Wildan Khairi Nofriyanti - Nofriyanti Nofriyanti Nofriyanti Nofriyanti Nofriyanti Ratna Sari Dewi Suci Nurhafizah Wira Noviana, Wira Noviana