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All Journal Jurnal Surya Medika Jurnal Penelitian Pendidikan IPA (JPPIPA) Warta LPM KOPEMAS
Aguslina Kirtishanti
Universitas Surabaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health Social Sciences

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Outcome Terapi Covid-19 pada Pasien yang Mendapatkan Antikoagulan Profilaksis di RSPAL Dr. Ramelan Surabaya: Outcome Covid-19 Anticoagulant Prophylaxis in Covid-19 Patients at Dr. Ramelan Naval Center Hospital Surabaya Rizki Damayanti; Anita Purnamayanti; Aguslina Kirtishanti; Ediyono Ediyono
Jurnal Surya Medika (JSM) Vol. 8 No. 3 (2022): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v8i3.3727

Abstract

Complications of thrombotic and hemorrhagic coagulation often occur in Covid-19 patients, so it is advisable to provide anticoagulant therapy, accompanied by monitoring of parameters of coagulation abnormalities, including D-Dimer. This study aims to determine the outcome of therapy for Covid-19 in patients with anticoagulant prophylaxis use in RSPAL Dr. Ramelan Surabaya. This study is a retrospective descriptive study based on medical records of Covid-19 patients from June-August 2021. The sample in this study was subjects aged >18 years who were confirmed positive for Covid-19 based on RT-PCR, with comorbid or without comorbidities, and received anticoagulant therapy. Then, this study did not include subjects who were pregnant or with malignancy/acute conditions. From 134 research samples, it was found that the use of anticoagulants using a single anticoagulant (n=131, 97.76%) was more widely used, with the most frequently used types being enoxaparin (n=68, 50.75%), and heparin (n=48, 35,8%). In conclusion, the recovery percentage in Covid-19 subjects with anticoagulant therapy was 77.61%, and the percentage of mortality was 22,39%.
PENDAMPINGAN KESEHATAN MASYARAKAT TENTANG IMUNISASI DASAR DAN ASI EKSKLUSIF PADA ANAK DI KABUPATEN MOJOKERTO Aguslina Kirtishanti; Sylvi Irawati; Jefman Efendi Marzuki; Chatarina Yayuk Trisnawati
Konferensi Nasional Pengabdian Masyarakat (KOPEMAS) #5 2024 Konferensi Nasional Pengabdian Masyarakat (KOPEMAS) #5
Publisher : Konferensi Nasional Pengabdian Masyarakat (KOPEMAS) #5 2024

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Abstract

Stunting adalah gangguan tumbuh kembang anak akibat gizi buruk, infeksi berulang, dan stimulasi psikososial yang tidak memadai. Stunting dapat disebabkan banyak faktor antara lain adalah pengasuhan yang kurang baik meliputi pemberian ASI dan makanan pendamping ASI (MP-ASI) dan kurangnya imunisasi pada anak. Kegiatan pengabdian kepada masyarakat ini dilakukan melalui pendampingan pentingnya imunisasi dasar lengkap pada anak dan ASI eksklusif pada bayi sampai usia 6 bulan dan 2 tahun dengan tujuan untuk mengatasi dan mencegah kejadian stunting di Desa Duyung, Kecamatan Trawas, Kabupaten Mojokerto.  Metode kegiatan yang dilakukan terdiri dari tiga tahap yaitu persiapan, pelaksanaan dan evaluasi. Hasil capaian dari kegiatan ini adalah skor pengetahuan partisipan atau warga Desa Duyung meningkat setelah kegiatan pendampingan pentingnya Imunisasi Dasar Lengkap pada Anak dan pendampingan pentingnya ASI Eksklusif pada Bayi sampai usia 6 Bulan dan 2 Tahun. Partisipan memahami penjelasan materi pendampingan dan merasa puas terhadap kegiatan tersebut. Monitoring dan evaluasi perlu dilakukan secara terus menerus terhadap kedua kegiatan tersebut untuk mencapai tujuan akhir yaitu penurunan kejadian stunting di Desa Duyung, Kecamatan Trawas, Kabupaten Mojokerto.
Activities of Chalcone Derivatives from Boesenbergia rotunda Against Human Estrogen Receptor Alpha of Breast Cancer by In Silico Maria Claudya; Dini Kesuma; Aguslina Kirtishanti; I Gede Ari Sumartha; Marsha Anggita Amelia
Jurnal Penelitian Pendidikan IPA Vol 10 No 10 (2024): October
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i10.8865

Abstract

The high prevalence of cancer must be overcome with prompt and appropriate prevention and treatment. New drug design is an effort to develop existing drugs, and their molecular structure and biological activity have been known through structural modification. It encourages researchers to explore Indonesia's natural resources, especially plants with anticancer activity, namely by synthesizing chalcone-derived compounds derived from the isolation of Fingerroot rhizomes (Boesenbergia rotunda). The most common flavonoid compound found in rhizomes fingerroot plants is pinostrobin. Pinostrobin compounds and their derivatives are synthesized, resulting in chalcone compounds and their derivative modifications. The author conducted an in-silico test on pinostrobin compounds and 19 of their derivatives, chalcone compounds, and 18 derivatives using estrogenic-a receptors with PDB codes 3ERD and 1G50. The author hoped that from this silico test, compounds with more potential as anticancer for breast cancer would be obtained based on the results of docking with 3ERD and 1G50 receptors and can then be synthesized. In the results of this study, the compounds Bis-4-bromobenzyoxychalcone and Bis-4-chlorobenzyloxychalcone are the most appropriate compounds to be synthesized. It is hoped that in the future, they can be continued with activity tests of these compounds, both in vitro and in vivo, because these compounds are predicted to have the best activity and do not have hepatotoxic or other toxicity effects
Molecular Docking: Study of Chalcone Derivatives from Boesenbergia pandurata Targeting Estrogen Receptor Alpha (ER–a) for Breast Cancer Marsha Anggita Amelia; Dini Kesuma; Aguslina Kirtishanti; I Gede Ari Sumartha; Maria Claudya
Jurnal Penelitian Pendidikan IPA Vol 10 No 11 (2024): November
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i11.8734

Abstract

The increasing number of cancer patients and the challenge of multidrug resistance (MDR) demand more effective drugs, which can be developed by modifying compounds derived from natural resources, such as the flavonoid-rich temu kunci rhizome (Boesenbergia pandurata (Roxb.) Schlecht.). This study aims to predict the cytotoxicity and toxicity of 20 Pinostrobin derivatives and 19 Chalcone derivatives as potential anticancer candidates. Estrogen receptor alpha (ER-α), a validated cancer therapy target, was used for molecular docking in in silico tests using Molecular Graphics Laboratory (MGL) Tools (including, AutoDock Vina, AutoDock Tools 4.1, and Python 2.5.2) and PyRx Program. Toxicity was predicted using the pkCSM program and Protox online tool. The docking process involved binding the compounds to ER-α (PDB IDs 6CHZ and 3ERT), with the binding energy indicating activity; lower binding energy values suggest greater cytotoxic potential and stronger ligand-receptor interactions. The results showed that Chalcone derivatives from temu kunci exhibited lower toxicity and higher cytotoxic activity compared to Pinostrobin derivatives and the reference compound, Tamoxifen (TAM). Notably, Bis-3-chlorobenzyloxychalcone and Bis-2-chlorobenzyloxychalcone demonstrated the highest predicted cytotoxic activity. In conclusion, Chalcone derivatives are promising candidates for further development as more effective anticancer drugs, especially those that outperform Tamoxifen. These findings highlight the potential of natural compounds, particularly Chalcone derivatives, in combating cancer while addressing the growing challenge of MDR in clinical treatments.
Pencegahan dan Penanganan Skabies di Desa Pulopancikan, Gresik Tiara Prima Ninting Novansca; Agung Anjar Sukmantoro; Widhi Nastiti; Viera Permatasari Wiana; Diana Rahman; Iqhro’ Samudro Thirto Buono; Khresno Bhirowo Ghusti Buono; Siti Hafida Nur Hidayati; Wijayaningrum Wijayaningrum; Aguslina Kirtishanti; Eko Setiawan; Ika Mulyono Putri Wibowo; Astrid Pratidina Susilo
Warta LPM WARTA LPM, Vol. 27, No. 2, Juli 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/warta.v27i2.4743

Abstract

Scabies is a contagious skin disease with a predisposition to people who live in densely populated areas. Pulopancikan Village has the highest prevalence of scabies among other villages in Gresik, East Java. From the results of a survey of visits to the homes of Pulopancikan Village residents, it was concluded that the high level of scabies transmission in the village occurred due to a lack of public knowledge about the disease, especially in terms of prevention and treatment. The aim of this program is to intervene in the form of community education, creating educational feedback sheets, and distributing checklists for preventing and treating scabies at home. This intervention is aimed at mothers or families who have children with scabies health problems. Knowledge tests were carried out before and after the intervention to evaluate the project, which showed a significant difference in increasing the knowledge of the Pulopancikan Village community (p<0.05). However, in this program, the long-term impact of increasing this knowledge cannot yet be known. Therefore, it is necessary to carry out long-term investigations to see the impact of interventions on behavior change, including prevention and regularity of therapy, and reducing the prevalence of scabies. To prevent further transmission, adequate health education must begin when the patient is diagnosed with scabies at the Community Health Center, involving an interprofessional team such as doctors and pharmacists.
Co-Authors Agung Anjar Sukmantoro Anita Purnamayanti Astrid Pratidina Susilo Chatarina Yayuk Trisnawati Diana Rahman Dini Kesuma Ediyono Ediyono I Gede Ari Sumartha Ika Mulyono Putri Wibowo Iqhro’ Samudro Thirto Buono Jefman Efendi Marzuki Khresno Bhirowo Ghusti Buono Maria Claudya Marsha Anggita Amelia Rizki Damayanti Setiawan, Eko Siti Hafida Nur Hidayati Sylvi Irawati Tiara Prima Ninting Novansca Viera Permatasari Wiana Widhi Nastiti Wijayaningrum Wijayaningrum